MRI-Guided brain zaps aim to ease depression
NCT ID NCT05577481
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a personalized form of brain stimulation called iTBS for people with major depression. Researchers used MRI scans to target specific brain areas in 68 participants. The goal was to see if this tailored approach could improve depression symptoms more than a sham treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- intermittent theta burst stimulation (iTBS) combined with antidepressants
- What this could lead to
- If successful, this could lead to a more effective, personalized brain stimulation treatment for depression, potentially improving symptom relief.
- What could go wrong
- This is a small, early-phase study (68 participants) that may not show clear benefits over sham. The approach is complex and may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
XijingH
Xi'an, Shaan'xi, 710032, China
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