MRI-Guided brain zaps aim to ease depression
NCT ID NCT05577481
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a personalized form of brain stimulation called iTBS for people with major depression. Researchers used MRI scans to target specific brain areas in 68 participants. The goal was to see if this tailored approach could improve depression symptoms more than a sham treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
intermittent theta burst stimulation (iTBS) combined with antidepressants
What this could lead to
If successful, this could lead to a more effective, personalized brain stimulation treatment for depression, potentially improving symptom relief.
What could go wrong
This is a small, early-phase study (68 participants) that may not show clear benefits over sham. The approach is complex and may not work for everyone.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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XijingH
Xi'an, Shaan'xi, 710032, China