Could talking therapy ease HIV-Related depression? small study tests culturally adapted CBT

NCT ID NCT07235852

Completed Symptom relief Sponsor: Khyber Medical University Peshawar Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested a six-session culturally adapted cognitive behavioral therapy (Ca-CBT) for depression and anxiety in 50 people living with HIV in Pakistan. The therapy was delivered by trained HIV health workers and included culturally relevant stories and materials. The study aimed to see if the approach is feasible and acceptable, not yet whether it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Culturally Adapted Cognitive Behavioral Therapy (Ca-CBT)
What this could lead to: If successful, this could provide a practical, low-cost therapy to ease depression and anxiety in people living with HIV, especially in low-literacy settings.
What could go wrong: This is a small pilot study (50 participants) focused on feasibility, not effectiveness. Results may not apply to other populations, and the therapy may not reduce symptoms significantly.

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression depressive disorder HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY DISORDERS DEPRESSION HIV INFECTIONS

Contacts and locations

Locations

Family Care Centre (FCC), Hayatabad Medical Complex

Peshawar, Khyber Pakhtunkhwa, 25000, Pakistan

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