New pill could ease severe depression

NCT ID NCT06259526

Completed Symptom relief Sponsor: Tasly Pharmaceutical Group Co., Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tested whether a new drug called JS1-1-01 can safely reduce symptoms in 267 adults with moderate to severe depression. Participants took either the drug or a placebo for 8 weeks. Researchers measured changes in depression scores to see if the drug helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: JS1-1-01 pills
What this could lead to: If successful, this could point toward a new treatment option for people with moderate to severe depression.
What could go wrong: This is an early-phase trial with only 267 participants, so results may not apply to everyone. The drug may not work better than placebo or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION

Contacts and locations

Locations

Capital Medical University Affiliated Anding Hospital

Beijing, Beijing Municipality, China
Chongqing 11th People's Hospital

Chongqing, Chongqing Municipality, China
Chongqing Mental Health Center

Chongqing, Chongqing Municipality, China
Daqing Third Hospital

Daqing, Heilongjiang, China
Hebei Provincial Mental Health Center

Baoding, Hebei, China
Huzhou Third People's Hospital

Huzhou, Zhejiang, China
Jiangxi Provincial Psychiatric Hospital

Nanchang, Jiangxi, China
Jilin Provincial Neuropsychiatric Hospital

Siping, Jilin, China
Peking University Sixth Hospital

Beijing, Beijing Municipality, China
Shandong Provincial Mental Health Center

Jinan, Shandong, China
The Affiliated Brain Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China
The First Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, China
The First Hospital of Hebei Medical University

Shijiazhuang, Hebei, China
Tianjin Anding Hospital

Tianjin, Tianjin Municipality, China
Wuxi Mental Health Center

Wuxi, Jiangsu, China
Zhenjiang Mental Health Center

Zhenjiang, Jiangsu, China
Ürümqi Fourth People's Hospital

Ürümqi, Xinjiang, China

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