DEPRESSION

This study tests whether special reflective roof coatings can lower indoor temperatures and improve health for 800 households in Colima, Mexico. Researchers will measure heart rate, blood sugar, depression, and other health factors over time. The goal is to find a simple, low-cos…

This study tests two smartphone app programs designed to prevent anxiety and depression in adults who do not currently have these conditions. About 2,600 participants from Spain and Chile will use either a personalized app with interactive modules or a simpler educational version…

This study tests a personalized smartphone program designed to prevent depression and anxiety in adults who do not currently have these conditions. About 9,000 people in Spain aged 18-55 will use an app that creates a custom prevention plan based on their personal risk factors. T…

This study tests a specially designed program to help prevent depression in new and expectant parents of infants with Down syndrome. The program adds extra support for grief and social connections to an existing proven method. About 72 parents will take part in a small pilot stud…

This study tests a self-paced web program called WeACT for adult family caregivers of relatives with dementia. The program teaches skills to handle difficult thoughts and feelings. Researchers want to see if it is practical and helpful for improving mental health and coping. Part…

This study tests whether clemastine, a common antihistamine, can improve brain health and make antidepressants work better in older adults with depression. About 80 people over age 60 with major depression will receive either clemastine or a placebo alongside their antidepressant…

This small pilot study will test whether adding brief guided mindfulness exercises (using a smartphone app) to standard accelerated brain stimulation therapy can help people with major depression. Twenty adults already receiving the brain stimulation at the Medical University of …

This study looks at whether a short program of four weekly counseling sessions before lung cancer surgery can lower anxiety and depression in patients. About 138 adults scheduled for lung cancer surgery will be split into three groups: one getting the counseling, one that refuses…

This study tests a daily digital mindfulness program designed to reduce depressive symptoms in people who have finished treatment for breast, prostate, or colorectal cancer. About 76 participants with mild to moderate depression will listen to short audio exercises each day for s…

This study tests a workplace-based program for hospital service workers (like cleaners and food staff) who have depression and are not very active. The program includes phone therapy, coaching, social needs help, and text messages to support mood and exercise. Only 10 workers wil…

This study tests whether a special type of acupressure, given at times linked to the body's internal clock, can help older adults in nursing homes sleep better. Eighty people aged 60 and older will receive either real or fake acupressure for four weeks. Researchers will measure s…

This study tests a communication coaching program for young adults (ages 18-35) who have finished cancer treatment at least a year ago. The goal is to help them talk more easily with friends, which may reduce anxiety, depression, and feelings of isolation. Ten participants will t…

This study tests whether adding allopurinol, a medicine usually used for gout, can help people with major depression who haven't improved enough with standard antidepressants. About 70 adults with moderate to severe depression will receive either allopurinol or a placebo alongsid…

This study looks at whether giving esketamine continuously during breast cancer surgery can help reduce anxiety and depression in patients who already have mild-to-severe depression. About 142 women will take part, and their mood and sleep quality will be tracked before and after…

This study explores whether 8 weekly telehealth music therapy sessions can improve quality of life and reduce depression and anxiety in adults with autoimmune endocrine diseases (like Type 1 diabetes or Hashimoto's) and depression. Ten participants will have video sessions with a…

This study looks at whether therapeutic gardening can help depressed teenagers who hurt themselves. 66 teens with depression and non-suicidal self-injury will take part in gardening activities like planting and caring for plants. The goal is to see if this reduces self-harm, impr…

This study tests a computer-based cognitive behavioral therapy program designed to reduce depression in people caring for veterans. About 20 caregivers aged 18-65 with mild to moderate depression will use the program at home. Researchers will check if it improves mood and daily f…

This study tests a program designed to help hospital service workers who feel depressed and are not very active. The program includes phone counseling, work coaching, help with social needs, and text messages to support mood and exercise. About 60 workers will take part to see if…

This study looks at whether craniosacral therapy, a gentle manual therapy, can help reduce pain, depression, and improve body awareness and quality of life in primary caregivers of people with special needs. About 30 female caregivers will either receive the therapy or be in a co…

This study looks at whether a trained peer mentor, along with text messages over 12 months, can help caregivers of people with dementia feel less lonely and more confident finding end-of-life resources. About 330 caregivers will take part. The goal is to improve caregiver well-be…

This study tests whether a gentle brain stimulation treatment for depression works just as well when done at home as it does in the hospital. Sixty-six adults with moderate to severe depression will receive 20 sessions of transcranial direct current stimulation (tDCS), either at …

This study looks at whether a type of therapy called EMDR, done in a group, can help adults who survived the April 2025 Silivri earthquake in Turkey. About 40 people will be randomly assigned to either get the therapy right away or wait. Researchers will check for changes in PTSD…

This study tests whether short weekly exercises delivered through a mobile app can help first-time parents manage their emotions and stress during pregnancy. Expecting mothers and fathers in Singapore will use the app, wear a Fitbit, and complete surveys about their well-being an…

This study tests whether a mobile phone app can help African Americans with depression feel better. Participants attend six weekly 90-minute classes on their phone and complete surveys. The goal is to see if the app reduces symptoms of depression and anxiety. The study is small, …

This study tests a new program called BRIDGES, designed to help teenagers with depression become more physically active in a way that feels right for them. Researchers will enroll 60 adolescents aged 12-19 who are currently receiving outpatient care for depression and are not ver…

This study tests whether giving esketamine during breast cancer surgery can help reduce severe depression and anxiety in the days around the operation. About 242 women with severe depressive symptoms will be randomly assigned to receive either esketamine or a placebo during their…

This study tests a smartphone app designed to help teens aged 14-18 who hurt themselves on purpose and are not currently in therapy. The app provides support and information to help them cope. The goal is to see if the app is easy to use and helpful, so it can be tested in a larg…

This study tests a digital program called Living Well, which includes a smartphone app and coaching, to see if it can reduce anxiety and lower healthcare costs for people with breast cancer. Fifty adults with stage II to IV breast cancer and moderate-to-severe anxiety will use th…

This study tests whether a mild electrical stimulation of a nerve in the ear, given during breast cancer surgery, can lower feelings of anxiety and depression after the operation. About 232 women will receive either the real stimulation or a fake version, and researchers will tra…

This study tests whether a Mediterranean diet adapted for Hong Kong Chinese adults can reduce depressive symptoms. 90 adults with moderate to severe depression will follow the diet or a control group, with mood tracked via frequent phone surveys. Researchers will also examine if …

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can help healthcare workers who feel depressed and have lost meaning in their work. About 72 doctors, nurses, and other clinicians will take part in small group retreats. Research…

This study tests whether internet-based group cognitive behaviour therapy (GCBT) delivered over Zoom can reduce symptoms of anxiety and depression in international students in Malaysia. 128 participants will be randomly assigned to either the therapy program or a waitlist. The pr…

This study tests a guided self-help CBT manual called 'Khushi or Khatoon' for cancer patients with anxiety and depression. About 108 adults with cancer and moderate to severe distress will use the manual and be compared before and after treatment. The goal is to see if it improve…

This study looks at whether reading a personal narrative book can help women of childbearing age manage anxiety, depression, and negative thoughts before having a hysterectomy. About 156 women will either get standard care or also receive a book to read. The goal is to see if the…

This study looks at whether using virtual reality can help reduce depression in teenage girls. About 48 girls aged 13 to 18 with mild to moderate depression will use VR and complete questionnaires about their mood and quality of life. The goal is to see if VR can be a helpful too…

This study tests a new way to treat emotional disorders like anxiety and depression by combining face-to-face therapy sessions with a smartphone app. The goal is to see if this blended approach is practical, helpful, and liked by patients in primary care. About 45 adults will be …

This study tests whether playing a virtual reality music-and-movement game can improve social connection and well-being in young adults aged 18-25 with mild to moderate depression or anxiety. Participants will be placed into one of three groups: a VR social game, a VR solo game, …

This study tests whether using a virtual reality (VR) headset during a breast biopsy can lower feelings of depression, anxiety, and stress. About 80 women will either wear a VR headset showing a calming scene for 15-30 minutes or receive standard care. Researchers will compare th…

This study tests whether a dietary supplement called GynMDD, taken alongside weekly talk therapy, can improve symptoms of mild to moderate depression more than therapy alone. About 168 adults aged 18 to 65 will take either the supplement or a placebo daily for 8 weeks and report …

This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can ease a cluster of tough symptoms—pain, fatigue, trouble sleeping, anxiety, depression, and brain fog—in breast cancer survivors who are on hormone therapy. About 228 women will get e…

This study will test whether a 16-week Pilates program done at home via video calls can improve walking, balance, fatigue, and pain in people with multiple sclerosis (MS). About 50 adults with mild to moderate MS will be assigned to either the Pilates group or a waitlist. Researc…

This study looks at whether a program combining yoga, meditation, and mindful eating can lower stress, anxiety, and depression in university students. About 60 students will attend weekly sessions for a semester and fill out questionnaires to measure changes. The goal is to see i…

This study will test a mindfulness-based stress reduction program for nursing students. The goal is to see if it helps them better manage stress, anxiety, and depression, and improves their overall well-being. About 93 students will take part, learning techniques like breath awar…

This study looks at whether adding a peer support program to a self-help version of Cognitive Processing Therapy (CPT) can help women veterans with PTSD feel better and improve their mental well-being. About 100 women veterans with PTSD or subthreshold PTSD will take part. The go…

This study tests a web-based program to help people with advanced cancer and their caregivers. The program aims to reduce symptoms like depression, pain, fatigue, and sleep problems in patients, and lower stress and depression in caregivers. About 40 patient-caregiver pairs will …

This study tests a new tablet called JS1-1-01 in 180 adults aged 18-65 with moderate to severe depression. Participants will receive either the drug or a placebo to see if it safely improves mood. The main goal is to measure changes in depression scores over time.

This study tests a faster version of a brain stimulation treatment called iTBS for people with depression. Instead of daily sessions for weeks, participants receive 30 short sessions over 5 to 14 days. The goal is to see if this quicker approach works well and is tolerable in rou…

This study tests a 6-week program combining group reading discussions with simple mouth exercises for adults aged 55 and older. The goal is to see if this non-drug approach can reduce depression, improve physical and oral health, and build mental toughness. Sixty participants wil…

This study tests whether a gentle hand-holding method called Jin Shin Jyutsu can improve quality of life and reduce stress, anxiety, and depression in women going through perimenopause. Sixty women aged 40-54 will practice the technique daily for two weeks and report how they fee…

This study tests whether a mild electrical pulse to a nerve in the ear during heart surgery can lower the chance of confusion (delirium) and reduce anxiety and depression after the operation. About 270 adults having planned heart surgery will receive either the real stimulation o…

This study looks at whether community health workers (CHWs) can effectively deliver a mental health program to Spanish-speaking Latine parents who have depression, anxiety, or traumatic stress. About 52 parents will either get the program right away or after a 5-month wait. Resea…

This study looks at whether adding a mental health app to remote therapy sessions helps reduce depression in adults aged 50 to 80. About 60 people with mild-to-moderate depression will take part. The goal is to see if the app makes treatment more acceptable and effective.

This study will test a smartphone app called CONEMO to help adults with depression, anxiety, and insomnia. About 12,400 people from primary care clinics in Brazil will use the app to track and improve their symptoms. The goal is to see if the app helps people feel better and redu…

This study tests a brain stimulation treatment called TMS to see if it can ease both depression and concussion symptoms in female athletes. About 35 women aged 18-65 with a recent concussion and moderate-to-severe depression will receive the treatment. The goal is to improve mood…

This pilot study tests a guided self-help program for veterans with moderate depression. The program uses coaching sessions to help veterans follow a self-help workbook based on behavioral activation. The goal is to see if this approach is practical and helpful for veterans in VA…

This study looks at whether teaching mindfulness skills to pregnant women who are at risk of delivering early (before 37 weeks) can help lower their stress, anxiety, and depression. About 60 mothers admitted to the hospital will take part in a 4-week mindfulness program. Research…

This study tests whether a single oral dose of CYB003, a drug related to psilocybin, can help ease symptoms of depression and anxiety in 40 adults with major depressive disorder. Participants will receive either the drug or a placebo, and researchers will use brain scans and ques…

This study looks at whether a self-help program can improve daily life and reduce symptoms for 200 post-9/11 veterans who have depression or PTSD but are not currently in therapy. The program teaches healthy coping skills and how to find mental health or whole-person care if need…

This study tests a structured psycho-social program (PSP) designed to help adults with type 2 diabetes manage mental health issues like depression and diabetes distress. The program teaches coping skills, stress management, and healthier thinking patterns. Researchers will measur…

This study tests whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression after the operation. About 218 adults having breast cancer removal will be randomly assigned to receive esketamine or a placebo during anesthesia. Re…

This study tests an 8-week digital lifestyle program for migrants in Sweden who feel stressed, anxious, or depressed. The program focuses on healthy habits like exercise, sleep, diet, and social connection. Researchers want to see if it improves mental well-being and is easy to u…

This study looks at whether adding sleep-focused treatments to standard psychiatric care can reduce suicide risk in young adults who are already in an intensive outpatient program for depression and suicidal thoughts. About 90 college students with sleep problems will be randomly…

This study tests a visual safety plan designed for autistic teenagers aged 13-18 who have had recent suicidal thoughts or self-harm. About 90 participants will either get the visual plan plus standard care or standard care alone. Researchers will check if the plan is easy to use,…

This study will develop and test a digital mental health program called 'VIBE in the Parks' for teens and young adults (ages 13-24) who visit Chicago Park District programs. About 268 participants will either use the digital program or receive a digital workbook. The goal is to s…

This study tests whether listening to positive self-affirmation audio recordings can reduce pain, depression, anxiety, and stress in women who have had a mastectomy. Forty-two participants will be split into two groups, with one group listening to the affirmations daily. The goal…

This study tests if combining a gentle electrical brain stimulation (tDCS) with computer-based memory games can improve thinking and memory in adults over 60 with recurrent depression. Participants will be assigned to one of three groups to compare active stimulation plus targete…

This study tests two different areas of the brain to see which one responds better to a gentle electrical current (tDCS) for treating depression. About 50 adults with depression will receive either stimulation to the left DLPFC or the DMPFC. The goal is to find out which target i…

This study tests whether metformin, a diabetes drug, can help treat depression in people living with HIV. Depression is common in HIV and can make it harder to stick with life-saving HIV medication. The trial will enroll 600 adults in Uganda and compare metformin to placebo, and …

This small study with 10 adults aged 18-50 who have early psychosis aims to see if smartphone sensors can detect moments of low mood and then offer quick mental health exercises like mindfulness. Participants will use a study app for 10 weeks. The goal is to learn if this approac…

This study looks at how heart rate variability (a measure of nervous system health) relates to emotional control and parent-teen relationships in 74 adolescents aged 12-18 with major depression. Participants wear a Fitbit while sleeping for a week and complete questionnaires. The…

This study tests a digital app and peer navigators to help youth ages 13-22 connect with mental health services in schools and clinics. The app was co-created with the community and is supported by culturally responsive navigators. Researchers will track how many youth are referr…

This study looks at whether data from smartphones and smartwatches can help predict how well women with depression during or after pregnancy respond to treatment. About 250 women will receive standard therapy and coaching, and their digital data will be collected for the first fo…

This study tests whether a non-invasive brain stimulation technique called tDCS, used at home, can improve sleep quality in adults with moderate depression. Researchers will track changes in sleep efficiency and mood over time. The goal is to understand if better sleep leads to f…

This study looks at how online cannabis ads that claim to help with anxiety or depression affect what people buy. About 2,000 adults who use cannabis and have mild-to-severe anxiety or depression will shop in a realistic online store. Researchers will see if these ads make people…

This study looks at how much physical activity health science professors and lecturers get and how it relates to their posture, sleep quality, mood, and muscle or joint pain. Researchers will survey 73 university staff members using questionnaires. The goal is to understand these…

This study looks at how the brain works differently in people with smell problems caused by things like infections or injuries. Researchers will use brain scans, smell tests, and questionnaires to track changes over one year. 80 adults (including healthy volunteers) will take par…

This study looks at whether simple, non-invasive artery tests can identify depression in people with chronic atrophic gastritis (CAG), a long-term stomach condition. Many patients with CAG have undiagnosed depression because they feel embarrassed to talk about it. The study will …

This study looks at why people with depression find it hard to put in effort during everyday tasks. Researchers will measure brain activity, heart rate, and energy use while participants choose between easy or physically demanding activities. The goal is to better understand the …

This study tests whether a chatbot can help first-time mothers learn about pelvic floor health and feel less lonely after childbirth. About 130 new moms will be randomly assigned to either standard care or standard care plus a 4-week chatbot. Researchers will compare knowledge, l…

This study aims to understand why cognitive-behavioral therapy (CBT) helps people reduce repetitive negative thinking, a common issue in anxiety and depression. Researchers will track 500 adults with elevated negative thought patterns over 16 weeks of CBT. The goal is to identify…

This study tests whether data from your smartphone (like activity and usage patterns) can warn doctors when depression symptoms are about to return. Researchers will track 320 adults who have been treated for depression and are currently well. If successful, this could lead to an…

This pilot study tests a new 3-5 minute communication tool called PEACE. It aims to reduce anxiety, depression, and trauma in 74 adults in Nigeria, while also improving public attitudes toward reintegrating former Boko Haram members. The study will check if the approach is accept…

This study looks at how different types of non-invasive brain stimulation change mood and brain activity in 200 adults with major depression. Participants will receive three types of stimulation (including a placebo-like sham) and undergo MRI scans while taking antidepressants. T…

This study will survey about 289 medical students and interns at Assiut University to find out how many experience anxiety or depression. Researchers will use standard questionnaires and look for links to academic performance and other risk factors. The goal is to better understa…

This study aims to create and test a new decision-making tool for therapists. The tool is designed to help them decide if and how to adjust standard mental health treatments to better match the cultural values and experiences of Latine youth and their families. Researchers will w…