DEPRESSION

This study tests a program that combines group counseling, financial literacy training, and savings accounts to help Ugandan teens with HIV manage depression and stick to their medication. About 588 adolescents aged 15-19 will take part. The goal is to see if this approach can re…

This study tests if special reflective roof coatings can lower indoor temperatures and improve health in Fiji. About 800 households will receive either a cool roof or usual care. Researchers will measure heart rate, blood sugar, depression, and other heat-related symptoms to see …

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study will test whether applying a special heat-reflecting coating to roofs can improve the health and well-being of 800 households in Colima, Mexico. The coating is designed to keep homes cooler indoors, which may help lower heart rate, improve blood sugar control, reduce d…

This study explores whether routine blood vessel tests can help identify depression in people with chronic atrophic gastritis, a stomach condition. Many patients with this disease have undiagnosed depression due to stigma. Researchers will use ultrasound and other vascular measur…

This study will test whether measuring a specific abnormal protein (alpha-synuclein) in spinal fluid can reliably distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease. Researchers will collect samples and perform cognitive tests on 286 older adults with suspected …

This study in Zimbabwe will screen women of childbearing age and high school students for HPV and Hepatitis B, then offer vaccines to those who are eligible. It also includes cognitive behavioral therapy for mental health issues. The goal is to see if this combined approach can p…

This study will test whether a personalized smartphone app can help prevent anxiety and depression in adults who do not currently have these conditions. About 2,595 people in Spain and Chile will use either a highly interactive app (Pandora-1), a simpler educational app (Pandora-…

This study tests whether a personalized smartphone app can prevent depression and anxiety in adults who do not currently have these conditions. Over 9,000 participants in Spain will use the app, which creates a custom plan with activities like exercise, sleep improvement, and pro…

This study tests a mobile app called Maya that teaches cognitive behavioral therapy skills to adults who recently had a stroke and feel depressed or anxious. Ten participants will use the app for a few weeks to see if it is easy to use and helps improve their mood. The goal is to…

This pilot study will test whether a mobile phone app can help reduce depression symptoms in African American adults. Eight participants will attend six weekly 90-minute classes through the app and complete surveys over four months. The goal is to see if this approach is effectiv…

This phase 2 trial tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, can improve depression in people with Parkinson's disease. Forty participants will receive a low to high dose with psychological support. The study measures changes in depressi…

This study will test whether smartphone sensors can detect when someone with early psychosis is feeling anxious or depressed and then offer a short mindfulness or psychoeducation exercise. Ten adults aged 18–50 with early psychosis and mild mood symptoms will use the app for 10 w…

This study tests whether a digital mental health platform called NAVO:J can help teens feel better. About 250 students will use the app in weekly group sessions at school for 17 weeks. Researchers will measure changes in depression, anxiety, stress, and resilience to see if the p…

This study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…

This study tests whether adding nitrous oxide (EMONO) to standard antidepressants can reduce depressive symptoms in nursing home residents aged 60 and older who have moderate to severe dementia. Participants receive either EMONO or medical air (placebo) via a face mask over sever…

This study tests whether combining the medication duloxetine with a structured walking program can improve physical function, reduce pain, and ease depressive symptoms in veterans with knee osteoarthritis. Participants will be assigned to either the drug-plus-exercise group or a …

This pilot study will test whether a 6-week app-based mental fitness program can improve wellbeing and self-compassion in anesthesiology residents. Sixty residents will be randomly assigned to either the mental fitness app or a control program. The main goal is to see if such a p…

This study tests whether virtual reality (VR) can help improve thinking and daily functioning in people aged 70 and older who have depression. Participants will do 12 VR sessions over 6 weeks, doing tasks like sorting groceries or following recipes. The main goal is to see if sen…

This pilot study will test a stepped-care approach for depression in 40 adults from primary care clinics. Participants will either use a mood-tracking app (Moodivate) alone, receive telehealth therapy, or start with the app and step up to therapy if needed. The main goal is to se…

This study tests whether reading specific self-help books can lower anxiety, depression, and rumination in university students aged 18-25. 110 students from health science programs will be randomly assigned to read one of two books or join a waiting list. Over 8 weeks, they will …

This study will test two smartphone apps, Tankevirus and Grubl, designed to help people with mild to moderate anxiety and depression. About 1000 Norwegian adults will use one of the apps or a placebo app for two weeks. Researchers will measure changes in symptoms and quality of l…

This pilot study will test whether adding a digital app to group cognitive-behavioral therapy (CBT) helps teens aged 12-17 who have both depression and overweight. Sixty participants will be randomly assigned to either CBT plus the app or CBT alone. The main goal is to see if the…

This study will test whether psilocybin, the active ingredient in magic mushrooms, can help treat depression. Fifty adults with depression will receive a 25 mg capsule of synthetic psilocybin along with therapy. Researchers will use MRI brain scans and other tests to see how psil…

This study tests whether a mobile app called SocialRx, which recommends personalized arts and cultural activities, can improve depression, anxiety, and loneliness in teens aged 15-18. About 230 teens with depression or anxiety will either use the app for a year or continue their …

This study tests if combining a gentle electrical brain stimulation (tDCS) with computer-based memory games can improve thinking and memory in adults over 60 with recurrent depression. Participants will be assigned to one of three groups to compare different combinations of activ…

This study tests whether a self-paced online program called WeACT can help family caregivers of people with dementia feel better mentally and emotionally. About 40 adult caregivers with mild to moderate depression will use the program for six weeks. Researchers will check if care…

This study will enroll 250 pregnant or postpartum women with moderate-to-severe depression to see if adding digital data from smartphones and smartwatches can better predict how well they respond to treatment. Participants will receive a 12-week program that includes online cogni…

This study tests whether adding allopurinol, a drug usually used for gout, to the antidepressant sertraline can better relieve symptoms of major depressive disorder. Researchers will enroll 70 adults with moderate to severe depression and measure changes in their depression score…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely help healthcare clinicians who feel depressed and have lost meaning in their work. Seventy-two doctors, nurses, and physician assistants will take part in small groups,…

This study compares doing brain stimulation (tDCS) at home versus in the hospital for people with moderate to severe depression. The goal is to see if home treatment works just as well, making care more accessible. Sixty-six adults will receive 20 sessions over two weeks, with nu…

This study tests a 6-week program for adults 55 and older that combines group book discussions with simple mouth exercises. The goal is to see if it can reduce depression, improve physical and oral health, and boost mental toughness. Half of the 60 participants will do the progra…

This study tests an 8-week mindfulness program designed to help nursing students reduce stress, anxiety, and depression while improving their emotional control. About 93 students will learn meditation, breathing exercises, and mindful movement. The goal is to see if these techniq…

This study tests an 8-week digital program that helps migrants in Sweden improve their mental health through better sleep, diet, physical activity, and social connections. 240 adults with moderate stress, anxiety, or depression will either get the program or a general wellness mo…

This study tests a computerized cognitive behavioral therapy (cCBT) program designed to help caregivers of veterans who have mild to moderate depression. Twenty caregivers will use the online course over several weeks. Researchers will measure how satisfied participants are and w…

This study tests a guided self-help program for veterans with moderate depression. Participants follow a workbook and get coaching sessions from their VA primary care team. The goal is to see if this approach is practical and helps reduce depression symptoms, potentially making m…

This study will develop and test a digital mental health program called 'VIBE in the Parks' for teens aged 13-24 who use Chicago Park District programs. About 268 participants will either get access to this program or a digital CBT workbook. The goal is to see if the program help…

This study looks at whether adding sleep-focused treatments to standard psychiatric care can reduce suicide risk in young adults. About 90 college students with suicidal thoughts and sleep problems will be randomly assigned to one of three sleep interventions. Researchers will tr…

This study will test if an internet-based cognitive behavioral therapy (iCBT) program can help reduce symptoms of mild-to-moderate anxiety and depression in adults in Singapore. About 390 participants will either receive the 8-week online program with counselor check-ins or conti…

This study tests a program designed to help low-wage hospital workers manage depression and become more active. The program includes counseling, work coaching, and text message support. About 60 workers will take part to see if the program is practical and improves mood, stress, …

This study tests a web-based program designed to help advanced cancer patients manage symptoms like depression, pain, fatigue, and sleep problems, while also supporting their caregivers. The program combines online tools with guidance from healthcare professionals. Researchers wi…

This study tests an experimental tablet called JS1-1-01 in 180 adults with moderate to severe depression. Participants will take either a low dose, high dose, or placebo for 8 weeks. The goal is to see if the drug safely reduces depression symptoms better than a placebo.

This study tests whether a smartphone app called SOLOMIYA is helpful and easy to use for people living under the stress of war in Ukraine. About 80 adults with mild to moderate depression or sleep problems will use the app for a few weeks. The app provides relaxation exercises, m…

This study tests a program called CommunityRx-Dementia, where trained peer mentors help caregivers of people with dementia. Over 12 months, caregivers get a personalized list of community resources, coaching, and supportive text messages. The goal is to reduce loneliness and help…

This study tests a brain stimulation treatment called TMS to help female athletes with both depression and concussion symptoms. About 35 women aged 18-65 who have had a concussion and have moderate to severe depression will receive the treatment. The goal is to see if TMS can imp…

This study will test whether doing Pilates exercises at home via video calls for 16 weeks can help people with multiple sclerosis (MS) walk farther and faster, improve balance, reduce fatigue and pain, and boost mood and thinking. About 50 adults with mild to moderate MS who can …

This study will test whether adding a mental health app called TREE-Connect to remote therapy sessions helps reduce depression in adults aged 50 to 80. Sixty participants with mild-to-moderate depression will use the app and attend therapy remotely. The main goal is to see if peo…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce a group of common symptoms—pain, tiredness, sleep problems, anxiety, depression, and memory fogginess—in breast cancer survivors who are on hormone therapy. About 228 women …

This study tests a device that gently stimulates a nerve in the ear during heart surgery. The goal is to see if it lowers the chance of postoperative delirium, anxiety, and depression. About 270 adults having elective heart surgery will be randomly assigned to receive real or sha…

This study tests whether playing a virtual reality music-movement game can improve mood and social connection in young adults aged 18-25 with mild to moderate depression or anxiety. Participants will be split into three groups: one playing a social VR game with others, one playin…

This study tests whether using a virtual reality headset for 30 minutes each week can reduce depression in teenage girls aged 13-18. Half the participants will use VR, while the other half take standard antidepressant pills. Researchers will measure changes in depression scores a…

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) during breast cancer surgery can help prevent or reduce negative emotions like anxiety and depression after the operation. About 232 women will receive either real or sham stimulation for 30 minut…

This study tests a structured psycho-social program (PSP) for adults aged 30-40 with type 2 diabetes who have mild-to-moderate mental health issues. Over 6-8 sessions, participants learn to manage stress, challenge negative thoughts, and improve daily habits. The goal is to reduc…

This study looks at whether craniosacral therapy, a gentle manual therapy, can reduce pain, depression, and improve body awareness and quality of life in primary caregivers of people with special needs. About 30 female caregivers aged 18-55 will either receive the therapy or be i…

This study tests whether a Mediterranean diet, adapted for Hong Kong, can reduce depression symptoms in 90 adults with moderate to severe depression. Participants will receive meal deliveries and track their mood and diet via phone surveys. The study also looks at how gut bacteri…

This study tests a program called REWIRE for teens aged 12-17 who feel anxious or depressed and use social media over 3 hours daily. The program aims to cut social media use by about half and replace it with positive offline activities like hobbies or time with friends. Researche…

This pilot study will test a 'blended' therapy approach for adults with emotional disorders like anxiety and depression. Participants will either receive standard face-to-face therapy, a mix of face-to-face sessions and a smartphone app, or be placed on a waitlist. The goal is to…

This study tests whether a dietary supplement called GynMDD, taken alongside weekly supportive therapy, can improve symptoms of mild to moderate depression more than therapy plus a placebo. 168 adults aged 18 to 65 will take either the supplement or a placebo daily for 8 weeks, c…

This study explores whether 8 weekly telehealth music therapy sessions can improve quality of life and reduce depression and anxiety in adults with autoimmune endocrine diseases (like Type 1 diabetes or Hashimoto's) who also have depression. Ten participants will meet with a boar…

This study looks at whether a program combining yoga, meditation, and mindful eating can lower stress, anxiety, and depression in university students. Sixty students will attend weekly sessions for a semester and fill out questionnaires to measure changes. The goal is to see if t…

This study tests whether a community-based programme can improve well-being and reduce loneliness in adults aged 55 and older who have mild depression symptoms. 300 participants will be randomly assigned to either an 8-week programme of well-being sessions and follow-up support, …

This study looks at whether community health workers (CHWs) can effectively provide a mental health program to Spanish-speaking Latine parents who have symptoms of depression, anxiety, or traumatic stress. About 52 parents will either get the program right away or after a 5-month…

This study tests whether a gentle hand-application method called Jin Shin Jyutsu can help perimenopausal women feel better emotionally and physically. Sixty women aged 40-54 will practice the technique daily for two weeks. Researchers will measure changes in quality of life, stre…

This study tests whether EMDR group therapy can help adults who experienced the April 2025 Silivri earthquake in Turkey. Forty participants will be randomly assigned to either the therapy group or a waitlist. Researchers will measure changes in PTSD, depression, anxiety, sleep qu…

This study tests whether internet-based group cognitive behavioral therapy (CBT) delivered over Zoom can reduce symptoms of anxiety and depression in international students in Malaysia. About 128 students with moderate to severe symptoms will be randomly assigned to either the th…

This study tests whether a single low dose of esketamine, given during anesthesia for breast cancer surgery, can reduce severe depression and anxiety symptoms right after the operation. Researchers will enroll 242 women with severe depression who are scheduled for breast cancer r…

This study tests whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression after the operation. About 218 women having breast cancer surgery will be randomly assigned to receive either esketamine or a placebo during anesthes…

This study looks at whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression in patients who already have mild-to-severe depression. About 142 women will take part, and their mood and sleep quality will be tracked after sur…

This study tests a special type of acupuncture—dense cranial electroacupuncture plus body acupuncture—in 148 teens aged 15-22 with mild to moderate anxiety or depression. Participants receive treatment twice a week for 8 weeks, and researchers measure changes in anxiety, depressi…

This study tests a daily digital mindfulness program designed to reduce depressive symptoms in people who have completed treatment for breast, prostate, or colorectal cancer. Researchers will enroll 76 participants with mild to moderate depression to see if the program is feasibl…

This study tests whether a special type of acupressure—timed to the body's natural daily rhythms—can improve sleep in nursing home residents aged 60 and older. Eighty participants will receive either real or fake acupressure twice a day for four weeks. Researchers will measure sl…

This study tests whether listening to positive self-affirmation audio recordings can help reduce pain, depression, anxiety, and stress in women who have had a mastectomy. Forty-two women will be randomly assigned to either listen to the affirmations or receive standard care. The …

This study tests whether metformin, a standard diabetes drug, can help treat depression in people living with HIV. Researchers will enroll 600 adults with HIV and depression, giving them metformin, fluoxetine (a standard antidepressant), both, or a placebo for up to 12 weeks. The…

This study tests a new visual safety plan designed for autistic teenagers who have had suicidal thoughts or self-harm. About 90 teens aged 13-18 will be randomly assigned to either get the visual plan plus usual care, or just usual care. The goal is to see if the plan is easy to …

This study will test a smartphone app called CONEMO in over 12,000 adults visiting primary care clinics. The app uses cognitive behavioral therapy techniques to help reduce symptoms of depression, anxiety, and insomnia. Participants will use the app on their own phones or tablets…

This study looks at whether therapeutic gardening can help teenagers with depression who harm themselves. 66 teens will take part in gardening activities like planting and caring for plants. The goal is to see if this reduces self-harm, improves mood, and helps with sleep and lon…

This study tests whether mindfulness-based cognitive therapy (MBCT), adapted for Vietnamese culture, can reduce depression symptoms and improve quality of life. One hundred sixty adults with mild-to-moderate depression will be recruited from eight Buddhist pagodas near Hanoi. Hal…

This study tests whether using a virtual reality headset during a breast biopsy can lower depression, anxiety, and stress. 80 women will either wear a VR headset showing calming nature scenes or receive standard care. Researchers will measure their mood before and after the proce…

This study tests whether a short, intensive psychological program before lung cancer surgery can lower anxiety and depression. About 138 adults scheduled for lung cancer surgery will be split into three groups: one receiving four weekly therapy sessions, one refusing support, and…

This study tests a guided self-help CBT manual called 'Khushi or Khatoon' for cancer patients with anxiety and depression. The manual uses culturally adapted stories and exercises over eight weeks. Researchers will enroll 108 adults in Pakistan to see if the manual is feasible, a…

This study looks at whether teaching mindfulness skills to pregnant women admitted to the hospital for risk of preterm delivery can reduce their depression, anxiety, and stress. Researchers will enroll 60 mothers and provide four weeks of mindfulness training. Participants will f…

This study will test a program called Living Well, which includes a mobile app with 21 mental health modules and personal coaching sessions, for breast cancer patients with moderate to severe anxiety. The goal is to see if the program can lower anxiety and reduce overall healthca…

This study tests whether a generative AI chatbot can help new mothers learn about pelvic floor health and reduce feelings of loneliness after childbirth. Researchers will compare standard postpartum care with or without access to the chatbot over 4 weeks. The trial involves 130 f…

This study combines virtual reality with a gentle electrical pulse on the ear (called taVNS) to help people with chronic shoulder pain who are waiting for surgery. The goal is to see if this drug-free approach can reduce pain, anxiety, and depression. Only 10 people will take par…

This study tests a self-help program for 200 post-9/11 veterans who have depression or PTSD symptoms but are not in therapy. The program teaches healthy coping skills and how to find support services. Researchers will compare the self-help group to those receiving standard resour…

This study will use advanced brain scans to see how a quick, 3-minute form of magnetic brain stimulation changes the brain in people with major depression. Twenty adults will receive one week of treatment and have PET and MRI scans before and after. The goal is to understand the …

This study uses a virtual reality task to measure how people with depression make decisions involving physical effort and reward. Participants will walk on a treadmill in a VR environment while researchers track brain activity, heart rate, and energy use. The goal is to better un…

This study aims to adapt a digital mental health app called Wysa for adolescent girls aged 13-18 in rural Uttar Pradesh, India, who have anxiety or depression. Researchers will work with the girls, their families, and community members to identify what helps or hinders app use an…

This study will enroll 500 adults with high levels of repetitive negative thinking (like worry or rumination) to understand why cognitive-behavioral therapy helps. Participants will receive one of two digital therapy programs: one focusing on concrete thinking, the other on self-…

This study looks at how heart rate variability (a measure of stress response) relates to emotional control and parent-teen relationships in 74 adolescents with depression. Teens will wear a Fitbit while sleeping for a week and fill out questionnaires. The goal is to better unders…

This study is testing a program called Mothers and Babies for Down Syndrome (MBDS) to help prevent depression in new and expectant parents of infants with Down syndrome. About 72 parents will take part in a small pilot study to see if the program helps with feelings of grief and …

This study looks at how physical activity levels are linked to posture, sleep quality, depression, and muscle or joint pain in health science professors and researchers at Istanbul Aydin University. About 73 academics aged 23 to 65 will fill out questionnaires. The goal is to und…

This study is creating a decision-support tool called CRAFTT to help therapists tailor mental health treatments to the cultural values and experiences of Latine youth (ages 5-15). The goal is to improve how well these treatments work and reduce mental health disparities. Research…

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study will analyze data from 500 adults to see if depression and asthma are connected, and if one might cause the other. Researchers will use medical records and genetic information to identify factors like age, smoking, or weight that could influence the link. No new treatm…

This study tests whether a smartphone app, co-created with teens, plus trained peer navigators can help more young people ages 13-22 get mental health care in schools and clinics. Over 8,000 youth will take part across multiple sites. The goal is to see if this approach increases…

This study explores whether data from your smartphone can warn doctors when depression symptoms are about to return. Researchers will collect phone data from 320 adults who have been treated for depression and are currently well. They will compare this data with monthly mood ques…

This pilot study tests a 3-5 minute recorded message called PEACE, designed to improve mental wellbeing and public attitudes toward reintegrating former Boko Haram members in Nigeria. Researchers will enroll 74 adults to see if the intervention is acceptable and feasible. The goa…

This study will give 40 adults with major depression and moderate-to-severe anxiety a single dose of CYB003 (a synthetic version of psilocin, the active ingredient in magic mushrooms) or a placebo. Researchers will use brain scans (fMRI, EEG) and questionnaires to see how the dru…

This study will survey about 289 medical students and interns at Assiut University to find out how common anxiety and depression are among them. Researchers will use standard questionnaires to measure symptoms and look for links to academic performance and other risk factors. The…