DEPRESSION

This study looks at whether combining medication with one-on-one cognitive behavioral therapy helps people with mental health disorders like anxiety, depression, bipolar disorder, and schizophrenia. 107 adults aged 18-65 with an IQ of 80 or higher took part. The goal is to see if…

This study looks at the best ways to add mental health care for depression into clinics that provide methadone treatment for opioid use disorder in Ukraine. About 1,350 patients from 12 clinics are taking part. The goal is to see if training doctors and offering small payments fo…

This study is testing a mobile app called Suubi-Mhealth for Ugandan youth aged 14-17 who have both HIV and depression. The app uses cognitive-behavioral therapy (CBT) to help improve mood and make it easier to stick with HIV medication. The goal is to see if the app can reduce de…

This study looks at the best ways to prevent anxiety and depression in older Latino adults (age 60+) who have mild symptoms but not a full disorder. About 240 participants will join either a health promotion program or a healthy lifestyles education class. Researchers will track …

This study compares two online sleep programs for pregnant people with insomnia to see if one can prevent depression after childbirth. About 456 participants will receive either digital cognitive behavioral therapy for insomnia or basic sleep hygiene education over six weeks. Res…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter trainees. About 480 recruits will take part during their academy training. They will either receive the emotion-regulation workshop o…

This study looks at a program called CATCH-IT, designed to prevent depression in teenagers aged 13 to 18 who have mild symptoms but are not currently depressed. Researchers will work with 400 teens from different healthcare systems to see how well the program works and how easy i…

This pilot study is testing a chatbot named SMILEY that teaches coping skills and safe social media practices to marginalized youth (ages 12-18) who experience depression and online victimization. Participants interact with the chatbot over 4 weeks to learn how to manage negative…

This study aimed to see if using virtual reality for guided mindfulness meditation could help adults with pain, stress, anxiety, or depression. Researchers planned to measure changes in mood and pain scores before and after VR sessions. However, the study was withdrawn before any…

This study tests if a prenatal yoga app can improve well-being in 50 pregnant African American women. Participants use the app for 12 weeks, wear a fitness tracker, and complete surveys. The goal is to see if the app is helpful and what cultural changes might be needed.

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help reduce depressive symptoms in people with Parkinson's disease. About 50 participants will be randomly assigned to receive either real rTMS or a …

This study looks at whether adding a special type of massage therapy to regular mental health care can help refugees and asylum seekers who survived torture or war. About 50 people will take part, with some getting massage plus standard care and others getting standard care alone…

This study tests whether using MRI scans to guide a noninvasive brain stimulation treatment (rTMS) works better than the usual scalp-based method for depression. About 54 veterans will participate. The study also offers a home-based brain stimulation and therapy program for those…

This study tests whether a 1-month meditation app can help juvenile justice officers and others working with court-involved youth feel less stressed, anxious, or burned out. About 57 adults who work directly with these youth will use the app and report how acceptable and helpful …

This study tests a therapy called FIRST, which uses five key principles to help youth aged 7 to 15 with anxiety, depression, trauma, or behavior problems. Researchers compare FIRST to usual care to see if it improves mental health and helps kids manage negative emotions. The stud…

This study tests whether watching a virtual reality (VR) video of an ECT session can reduce anxiety and improve understanding in people about to receive ECT for the first time. About 64 participants will be randomly assigned to either the VR experience or a standard talk with a p…

This study tests whether a short computer-based cognitive training can make ketamine's rapid antidepressant effects last longer and work better. Researchers will enroll 600 adults aged 18-80 with depression who are already receiving ketamine or esketamine treatment. The goal is t…

This study tests if a newer, deeper form of non-invasive brain stimulation can reduce depression symptoms more than the standard method. About 90 adults with major depression who haven't gotten better with medication will receive daily sessions for four weeks. Researchers will me…

This study tests if a mobile app called OkeyMind can reduce social anxiety and depression in young people aged 15 to 24. Participants use the app for one month, learning about anxiety and practicing meditation. The study will measure changes in symptoms and cost-effectiveness ove…

This study is testing whether adding nitrous oxide (laughing gas) to standard hospital care can quickly reduce suicidal thoughts in people with severe depression. About 50 adults with major depression and active suicidal thinking will be randomly assigned to receive either nitrou…

This study tests whether using a mindfulness app for 8 weeks can improve mental health in Korean immigrants aged 60 and older. Participants use the app 10-15 minutes daily and have weekly check-ins. The goal is to see if the app reduces stress, anxiety, and depression while boost…

This study tests a smartphone app called MS CATCH that lets people with multiple sclerosis regularly report their mood symptoms. The information is shared with their neurologist, who gets alerts if there are concerns. The goal is to improve depression screening and care. About 10…

This study tests two non-invasive devices that stimulate the vagus nerve (one on the neck, one on the ear) to see which better reduces physical discomfort and health-related anxiety in people with Somatic Symptom Disorder. About 60 adults will try both devices in random order, ea…

This study tests a short, 5-session counseling program called LEAD for fathers in Kenya who have depression and drink alcohol. About 102 fathers will be randomly assigned to get the program right away or wait. The goal is to see if the program helps fathers feel better, improves …

This pilot study tested whether a smartphone app can help current smokers quit. 24 participants from MD Anderson Cancer Center used the app to track their mood and activity levels. The goal was to see if the app improves mood and increases the chances of quitting smoking.

This study tests a short, acceptance-based behavioral therapy to help LGBTQ+ people who have mild anxiety or depression after the COVID-19 pandemic. About 240 adults will either receive this therapy or their usual care. The goal is to see if the therapy reduces symptoms and impro…

This study tests two non-drug therapies—mindfulness-based therapy and cognitive-behavioral therapy—for pregnant women with insomnia and depression. About 100 women in their second trimester will receive one of the treatments. The goal is to see which approach better reduces sleep…

This study looks at whether taking vitamin D supplements for six months can help people with depression feel better. Researchers will compare a low dose (10 micrograms) to a high dose (100 micrograms) and track participants for up to 6 years. The goal is to see if vitamin D impro…

This study tests a culturally tailored mobile health program for 150 Black pregnant women to see if it reduces symptoms of depression, anxiety, and stress. Half of the participants receive the app, which teaches communication and self-advocacy skills and offers a support network.…

This study looks at an accelerated version of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain treatment, to see how many sessions work best for reducing depression and anxiety symptoms. About 70 adults with major depression will receive different doses o…

This study tests whether adding computer-based cognitive training to standard esketamine treatment can improve depression symptoms. Researchers will enroll 40 adults aged 18-80 who are already receiving esketamine at the University of Pittsburgh clinic. The goal is to see if this…

This study tests a mobile app that uses cognitive behavioral therapy (CBT) to help treat depression. 146 adults with depression will use the app for 8 weeks, with weekly AI-guided lessons and homework. The goal is to see if the app reduces depression symptoms and to understand ho…

This study tests a new way to treat depression by combining brain stimulation (TMS) with a meditation-like state of focused attention. The goal is to improve how well TMS works for people with moderate to severe depression who haven't gotten better with antidepressants. About 50 …

This study looks at whether kava, a plant used for relaxation, can safely reduce anxiety and stress in people who have finished cancer treatment. About 43 survivors of breast, gynecologic, lung, or head/neck cancer will take either kava or a placebo for 14 days, then switch after…

This study aims to help mothers of babies in intensive care cope with depression, anxiety, and stress while also providing resources for food, rent, and utilities. About 200 caregivers of infants up to 6 months old will receive emotional support and referrals to community service…

This study tests a 12-session group therapy program designed to help active duty military personnel who are having suicidal thoughts or have recently attempted suicide. The therapy teaches coping skills and emotion regulation techniques to reduce suicide risk. Researchers will co…

This study is testing whether a relaxation technology called Cereset can help nurses on a hospital unit feel less stressed, anxious, and sleep better. About 40 nurses will use the device, which uses gentle sounds to guide the brain into a calm state. The goal is to see if this im…

This study looks at whether unlicensed professionals can provide cognitive behavioral therapy (CBT) to people with conditions like anxiety, depression, OCD, and PTSD. About 250 participants will receive therapy at Massachusetts General Hospital. The goal is to see if their mental…

This study tests a non-invasive brain stimulation method called iTBS as a stand-alone treatment for depression in people who choose not to take antidepressant medication. 72 participants are randomly assigned to start treatment right away or after a 4-week wait. The goal is to se…

This study compares two well-known psychological treatments for depression: cognitive-behavioral therapy (CBT) and acceptance and commitment therapy (ACT). Up to 100 adults with major depressive disorder will receive 8 weeks of online group therapy via Zoom. The goal is to see wh…

This study tests whether combining a special talk therapy for depression with standard smoking cessation help works better than standard help alone. About 91 adults with depression who smoke at least 5 cigarettes daily will take part. The goal is to see if this combined approach …

This study tests a behavioral program that combines mood management with smoking cessation support for pregnant women who are depressed and smoke. The goal is to help them quit smoking during pregnancy and stay smoke-free after giving birth. The study enrolled 26 participants and…

This study tests a telephone-based, computer-aided care program for adults with depression, anxiety, or risky drinking. Participants receive extra support from a Mental Health Technician who helps their primary care provider manage treatment. The goal is to see if this approach r…

This study compares a single dose of ketamine to a placebo (saline) given during sedation with propofol in 40 adults with chronic pain and depression. The goal is to see if ketamine works better than placebo under these conditions. Participants will be sedated, receive the infusi…

This study tests a program called MOSAIC Plus, which pairs pregnant women and mothers of young children who have experienced intimate partner violence with trained advocates. The program aims to reduce symptoms of depression and post-traumatic stress, and help prevent further vio…

This study looks at whether a gentle mind-body practice called qigong can improve mood and thinking skills in people aged 65 and older who have depression. Sixty participants will be randomly assigned to either a qigong group or an exercise group. Researchers will measure changes…

This study looks at whether two Akashic Records sessions (a spiritual practice exploring past life patterns) can help reduce stress, anxiety, and depression in adults. About 117 participants will attend private video sessions and complete surveys over two months. The goal is to s…

This study tests whether choosing depression treatments based on a patient's specific symptoms and brain imaging (phenotyping) leads to better results than standard care. About 150 adults with major depression will be enrolled. The goal is to see if personalized treatment selecti…

This study explores whether a non-invasive brain stimulation technique called LIFUP can reduce negative thinking and mind-wandering in people with depression. Researchers will use ultrasound to either increase or decrease activity in a brain region linked to self-focused thought.…

This study tests whether a gentle brain stimulation technique called tDCS can improve depression and other non-motor symptoms in people with Parkinson's disease. About 80 participants will receive either real or fake tDCS for 30 minutes over 10 sessions. The goal is to see if the…

This study tests whether an 8-week online therapy program called acceptance and commitment therapy (ACT) can reduce depression and improve quality of life in people with spinal cord injuries. About 140 adults with mild to moderate depression will be randomly assigned to either th…

This pilot study explores whether laughter yoga can reduce depression and anxiety in children aged 8-12 with autism spectrum disorder, and lower parenting stress in their parents. About 66 families will either join laughter yoga sessions or be placed on a waitlist. The study focu…

This study tests a new type of group therapy called Cognitive Evolutionary Therapy for people with mild to severe depression and anxiety. 64 adults will either receive two full days of therapy or be placed on a waitlist. Researchers will measure changes in mood, sleep, and stress…

This early study looks at whether a self-help technique called Emotional Freedom Techniques (EFT), or tapping, can reduce anxiety, depression, pain, and trouble sleeping in people with a rare bile duct cancer. About 14 participants learn EFT in group phone or online sessions and …

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training to help improve mood and thinking skills. About 70 adults with moderate-to-severe depres…

This study tests a 7-week group program led by trained peers (not doctors) to help cancer survivors reduce anxiety and depression after finishing curative treatment. 234 adults in Denmark who completed cancer treatment within the past year and have mild-to-moderate symptoms are t…

This study tests whether adding ear acupressure (sticking tiny seeds on ear points) to standard IVF care can help women aged 20-45 feel less anxious, sleep better, and possibly improve pregnancy rates. Participants will either receive standard medication alone or standard medicat…

This study looks at whether cancer patients can use meditation on their own to reduce anxiety and depression. About 35 patients will try techniques like deep breathing or movement for two weeks. The goal is to see if this approach is practical and helps improve emotional well-bei…

This study compares four commonly prescribed medications for bipolar depression in over 2,700 adults. The goal is to see which treatment helps people feel better and return to a normal mood. Participants will be randomly assigned to one of the four drugs and monitored for improve…

This early-stage study tests a smartphone app called NEAT-O that teaches coping skills to people with opioid use disorder who also have anxiety or depression. About 15 adults currently in medication treatment for opioid use will try the app for a few weeks. Researchers will check…

This study looks at whether recreational group drumming can improve the health of people aged 60 and older living in the community. Researchers will measure changes in quality of life, depression, sleep, and blood pressure after 12 weeks of drumming sessions. The goal is to see i…

This study tests if encouraging people in underserved communities to join rewarding community activities (like recreation and social groups) can improve depression, weight, and physical activity more than usual health advice. About 100 adults with mild to moderate depression and …

This study compares two online treatments for depression: group yoga and a type of behavior therapy called Brief Behavioral Activation (BA). About 518 adults with depression symptoms will be randomly assigned to one of the two groups for 12 weeks. Researchers will track mood chan…

This pilot study tests a 6-session psychological program called Y-MIND for young people aged 15-24 with depression in Zimbabwe. Trained local counselors deliver the sessions. The goal is to see if the program is practical and helpful, and to measure changes in depression symptoms…

This study follows over 19,000 older adults who previously took aspirin in a clinical trial. Researchers are monitoring for long-term effects, especially on cancer, dementia, and disability. No new treatment is given—participants just continue regular check-ups and phone calls to…

This study follows over 6,000 people over many years to see if traits like hostility and other emotional factors are linked to heart disease. Researchers are observing participants without giving any treatment. The goal is to better understand what leads to heart problems, not to…

This study looks at how to get a proven depression care service (HITIDES) into VA clinics that treat veterans with HIV. The service has been shown to work better than usual care and save money, but no VA clinic currently offers it. Researchers will compare two approaches to help …

This study tests whether brain wave (EEG) measurements can predict which people with depression will respond well to a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS). About 30 adults with depression will receive rTMS, and researchers will compar…

This study looks at how lithium, a common treatment for bipolar disorder, changes the brain's wiring. Researchers will use MRI scans to track brain connections in 120 people with bipolar depression over 26 weeks. The goal is to understand why lithium works, not to test a new trea…

This study looks at whether a video-based smartphone program can help reduce stigma and medical mistrust among Black adults (ages 18-45) who have depression or anxiety but haven't seen a mental health professional in the past year. About 90 participants will use the app and repor…

This study looks at whether a smartphone-based program can help veterans with depression begin and continue mental health treatment. Researchers will use medical records to find out who struggles to engage in care, then test an eHealth tool that lets veterans track their moods an…

This study explores whether taking antidepressants can lower inflammation in the gums of people who have both chronic gum disease and depression. Researchers will measure inflammatory markers in gum fluid and analyze plaque bacteria. The study involves 92 adults with moderate to …

This study looks at how well a team-based program for depression works in primary care clinics. About 778 adults with depression symptoms will take part. Researchers want to see if the program helps doctors identify and treat depression faster and more effectively.

This study tests a short, one-time online mental health program for 80 people waiting for psychological treatment. Participants will try one of two versions of the program or a control activity and fill out questionnaires over 5 weeks. The goal is to see if the program is easy to…

This study looks at how transcranial magnetic stimulation (TMS) affects the brains of people with major depression. Researchers will use MRI scans to measure changes in brain connections before and after TMS treatment. About 54 adults aged 18-80 who are already scheduled for TMS …

This study looks at whether giving doctors a quick summary of their patient's work-related challenges helps people with conditions like pain, stress, or anxiety return to work sooner. About 1180 adults in Norway will be randomly assigned to either standard care or care where the …

This study interviews 18 physiotherapists to understand how they screen for anxiety and depression in patients with chronic neck, shoulder, and low back pain. The goal is to identify what helps or hinders them from recognizing mental health issues and referring patients for care.…

This study follows 2,000 Stanford undergraduates over their college years to understand how social connections, daily moods, and brain activity relate to anxiety, depression, loneliness, and stress. Participants fill out surveys and some undergo brain scans. The goal is to learn,…

This study aims to create a registry of 5,000 young people (ages 8-20) with depression or suicidal thoughts across Texas. Researchers will collect data to better understand these conditions and develop models to predict outcomes. The goal is to improve care and support for affect…

This study looks at whether a simple brain wave test (EEG) can tell doctors which veterans with hard-to-treat depression will improve with a treatment called TMS (transcranial magnetic stimulation). About 266 veterans will get EEG scans before, during, and after TMS sessions. The…

This study aimed to see if holistic pastoral counseling could help people manage stress at work and in daily life. It was designed for unmarried Alaska Medicaid recipients aged 22 and older who had internet access and a Bible. However, the study was withdrawn before any participa…

This study follows 2,600 adults with coronary heart disease and depression who received a stent. Researchers track major heart problems like heart attacks or death over one year to find what predicts these events. The goal is to better understand how depression impacts recovery a…

This study was designed to see if a noninvasive device that stimulates the vagus nerve (tcVNS) could help patients regain consciousness faster after anesthesia, and reduce delirium and depression after surgery. It planned to enroll adults undergoing lumbar spine surgery. However,…

This study looks at why many veterans with PTSD, depression, or alcohol/opioid problems don't get proven treatments. It tests a method called Participatory System Dynamics, where patients, doctors, and leaders work together to improve care. The goal is to see if this approach wor…

This study is testing a more personalized way to use brain stimulation (rTMS) for major depression. Researchers will compare three different stimulation frequencies in 84 adults to see which one best targets the brain circuits involved in depression. The goal is to develop a more…

This study looks at whether having naturally low testosterone levels increases the risk of dementia, depression, or anxiety. Researchers will analyze genetic data from large biobanks (like UK Biobank) to see if certain genes linked to low testosterone are also linked to these men…

This study looks at whether watching short, educational videos (nano-learning) can help older adults with sarcopenia (age-related muscle loss) stick to diet and exercise advice and improve their mood. Researchers are testing this approach with 180 people aged 60 and older in a ru…

This study tests an 8-week school program called INSPIRE for Indonesian teens aged 13-15. The program aims to improve mental health knowledge, resilience, and reduce symptoms of depression and anxiety. About 680 teens and their parents will take part, with results measured right …

This study explores whether low intensity focused ultrasound (LIFU) can safely change brain activity in areas linked to depression and anxiety. It involves 25 veterans, some of whom will receive LIFU while undergoing brain scans. The main goal is to check safety and see if the te…

This study looks at whether a team-based plan can help doctors and staff better screen children for depression and connect them to mental health services. About 40 healthcare workers at a children's hospital will use a team charter to clarify roles and improve coordination. The g…

This pilot study is testing whether adults with acute psychiatric conditions like psychosis, anxiety, or depression can safely receive hospital-level care at home instead of in a hospital. Researchers are enrolling 41 participants to see how many people are eligible and willing t…

This study looks at how a brain area called the subgenual cingulate responds to transcranial magnetic stimulation (TMS) in people with depression. Researchers will use MRI scans to see if TMS activates this region and how it changes over a 6-week treatment course. 50 adults with …

This study aims to find biological markers in the brain that can predict how well a person with major depression will respond to different treatments. Researchers will use a special brain imaging technique (TD-fNIRS) to measure blood flow and other signals in 540 adults before th…

This study tests a program for refugee families living in the U.S. It combines family group sessions with virtual teen mentoring to help reduce emotional and behavioral problems like PTSD, depression, and anxiety in teens. About 308 teens and their parents will take part. The goa…

This study planned to test whether scheduled video or audio calls could improve communication and reduce anxiety and depression for family members making medical decisions for hospitalized older adults with Alzheimer's or other cognitive impairments. The study was withdrawn befor…

This study looks at whether the Norwegian Sickness Absence Clinic (NSAC) helps people with common mental health issues or muscle pain return to work faster. About 2500 adults will be split into three groups: one gets treatment within 4 weeks, another after 10-14 weeks, and a thir…

This study looks at two school-based programs to see if they can reduce depression, anxiety, and behavior problems in 7th graders while improving attendance and school climate. About 1,440 students, parents, and school staff from Oregon middle schools will take part. Researchers …

This study looks at brain scans of 100 Veterans with treatment-resistant depression to find patterns that predict whether transcranial magnetic stimulation (TMS) will help them. Participants receive routine TMS care while researchers use MRI to measure brain activity during tasks…

This study looks at how depression symptoms, like loss of interest, may make it harder for teens and young adults with lupus to keep up with their medical appointments. Researchers will test a mobile health app designed to improve both clinic engagement and depression. About 40 p…