DEPRESSION

This study is testing a smartphone app called MS CATCH, which helps people with MS track their mood symptoms. The app shares this information with their neurologist, who can then monitor changes and provide timely support. The goal is to improve how depression is reported, screen…

This study is testing how well a combination of medication and a specific type of talk therapy (cognitive behavioral therapy) helps people with various mental health conditions. It involves 107 adults with diagnoses like anxiety, depression, PTSD, bipolar disorder, or schizophren…

This study is testing whether taking vitamin D supplements can help people with depression feel better. It involves about 480 adults with depression who will take either a low or high dose of vitamin D daily for six months, while continuing their regular antidepressant treatment.…

This study is testing two different ways to help VA clinics start using a proven team-based service for managing depression in Veterans who are living with HIV. The service has been shown to improve depression symptoms and save money, but it's not yet available. Researchers are c…

This study is testing how a non-invasive brain stimulation technique, called TMS, affects a specific brain area linked to depression. Researchers will use MRI scans to see how this brain area responds during six weeks of daily TMS treatments. The goal is to better understand how …

This study is testing if combining a meditation-like breathing exercise with a magnetic brain stimulation treatment (rTMS) works better for depression than the stimulation alone. It involves 50 adults with moderate to severe depression who haven't gotten enough relief from antide…

This large study aims to find the best medication strategies for adults with bipolar disorder who are experiencing a depressive episode. It will compare four common treatment approaches, including three FDA-approved medications and one widely used combination. If a person's first…

This study aims to understand which specific skills in two common talk therapies work best for treating depression. Up to 100 adults with depression in California will be randomly assigned to receive 8 weeks of either online group Cognitive Behavioral Therapy (CBT) or Acceptance …

This study is testing a faster version of a non-invasive brain stimulation treatment called iTBS to help people with depression and anxiety. Researchers are working with 70 participants to figure out the best dose of this treatment to reduce symptoms. They are also looking at how…

This study is testing different ways to provide depression treatment to people receiving addiction medication at methadone clinics in Ukraine. Researchers are comparing standard care against two telehealth approaches that connect clinic staff with mental health experts. The goal …

This study is testing a special counseling program combined with nicotine patches to help people who smoke and have depression quit. It compares two approaches: one adds mood management therapy, while the other adds general health education. The goal is to see which method is bet…

This study is testing whether matching depression treatments to a person's specific symptoms works better than standard care. Researchers will first sort 150 adults with major depression into one of five subtypes, like trouble feeling pleasure or high anxiety. Then, half will get…

This is an early-stage study to test a smartphone app called NEAT-O. The app delivers a form of therapy (CBT) designed for people who have opioid addiction and also struggle with anxiety or depression. Researchers are testing if the app is easy to use and acceptable to 15 partici…

This study is testing a counseling program delivered by smartphone to help pregnant women who smoke and have depression. The program aims to help them quit smoking and improve their mood both during pregnancy and after their baby is born. Researchers are comparing two types of co…

This study is testing whether a structured physical activity program can help prevent colon cancer from coming back in people who have already had surgery and chemotherapy. It will compare a group that gets the exercise program plus health education to a group that gets health ed…

This study is testing two different ways of using non-invasive brain stimulation to help people with major depression who haven't gotten better with at least one antidepressant. Researchers will compare a newer method that targets a deeper brain area with the standard method that…

This study is testing a digital self-monitoring program designed to help veterans start and continue their depression treatment. It focuses on veterans who have been referred for mental health care but may struggle to begin or stay engaged. The program uses a phone or computer ap…

This study is testing a new community outreach program designed to help people with depression in underserved neighborhoods. The program encourages participation in fun, rewarding social and recreational activities, aiming to improve mood, increase physical activity, and support …

This study is testing whether a brief, computer-based brain training program can make ketamine's rapid antidepressant effects stronger and longer-lasting. It involves 600 adults with treatment-resistant depression who are already scheduled to receive ketamine treatment as part of…

This study is testing whether a non-invasive brain stimulation technique called iTBS can help reduce depression symptoms in people who choose not to take antidepressant medications. It involves 72 adults with depression in Germany who will receive either four weeks of immediate t…

This study is testing whether a new mobile app can help treat depression. The app delivers an 8-week digital therapy program based on cognitive behavioral therapy (CBT), guided by artificial intelligence. Researchers are measuring if using the app alongside standard antidepressan…

This study is testing a new, personalized approach to brain stimulation therapy for major depression. Researchers are trying to find the exact stimulation frequency that works best for each person's unique brain circuit, rather than using the same frequency for everyone. The stud…

This study is testing a special workshop, led by fellow firefighters, that teaches emotion regulation skills. It aims to prevent PTSD, depression, anxiety, and alcohol use problems in new firefighter recruits. Researchers will compare this workshop to standard mental health educa…

This study is testing if a specific online sleep therapy program can prevent depression in pregnant people who have trouble sleeping. It compares two different six-week digital sleep programs to see which one is better at reducing the risk of developing depression during pregnanc…

This study aims to find the best ways to prevent anxiety and depression in older Latino adults who are at risk for developing these conditions. It involves 240 participants who will be randomly assigned to either a health promotion program or a healthy lifestyles education progra…

This study is testing whether two school-based programs can help 7th grade students by reducing disciplinary referrals, improving attendance, and lowering depression and anxiety. Researchers are combining a school-wide discipline reform program with an online family support progr…

This study aims to find the most effective and practical version of an online program designed to prevent depression in teenagers. Researchers are testing different parts of the program with 400 teens who show early signs of depression but don't have a full diagnosis. The goal is…

This study is testing a brief, 5-session counseling program called LEAD, delivered by trained peer counselors, to help fathers in Kenya who are experiencing depression and some alcohol use. The goal is to see if this program improves fathers' mental health, parenting, and their c…

This study is testing if a chatbot named SMILEY can help teens who are depressed and have been bullied online. The chatbot teaches coping skills and safe social media practices over four weeks. Researchers want to see if using SMILEY makes teens feel less stressed and safer onlin…

This study is testing whether a short, intensive group therapy program can help reduce symptoms of depression and anxiety. Researchers are comparing people who receive the therapy to those on a waitlist. The therapy involves two full-day sessions over two consecutive days, led by…

This study is testing a community-based support program called MOSAIC Plus. It aims to help pregnant women and mothers of young children who have recently experienced intimate partner violence by reducing symptoms of depression and PTSD, and preventing further violence. The progr…

This study is testing whether a virtual reality (VR) education session can help reduce anxiety in patients about to undergo electroconvulsive therapy (ECT). Researchers are comparing the VR experience to the standard preparation of talking with a psychiatrist. They will measure a…

This study is testing whether smartphone apps can help people quit smoking, especially those who also experience symptoms of depression. Researchers are comparing two different apps over 8 weeks to see which one is more helpful for improving mood, increasing activity, and support…

This study is testing whether practicing a form of Qigong, an ancient Chinese mind-body exercise, can help reduce depression and improve thinking skills in older adults. Researchers will compare 60 participants aged 65+ with depressive symptoms, assigning them to either a Qigong …

This study is testing whether weekly group drumming sessions can improve the health and well-being of older adults living independently. Researchers are measuring effects on quality of life, mood, sleep, blood pressure, and grip strength. About 300 participants aged 60+ will eith…

This study is testing whether a computer-based brain training program can make depression treatment more effective. It involves 40 adults who are already receiving esketamine treatment for depression at a clinic. Researchers want to see if this training helps the brain learn in m…

This study is testing a special support program called ENCODE, designed to help family caregivers of hospice patients with dementia. Caregivers are randomly assigned to receive either friendly video calls for social support or the ENCODE program, which teaches skills to manage st…

This study is testing whether a single dose of ketamine works better than a placebo (saltwater) for reducing chronic pain and depression. The key twist is that participants are sedated and asleep when they receive the infusion, so they won't consciously feel its effects. Research…

This study is testing whether a non-invasive audio intervention can help improve the well-being and work performance of nurses and staff in a hospital unit. Up to 40 staff members will receive sessions where they listen to tones that echo their own brainwave activity. Researchers…

This study is testing a web-based support program designed to help advanced cancer patients manage symptoms like depression, pain, and fatigue. It also aims to reduce stress and depression in their spouses or partners who are providing care. The program is intended to be accessib…

This study aimed to see if a gentle, non-invasive device worn on the neck could help patients wake up faster and more clearly after spinal surgery. It planned to test if this stimulation could reduce post-surgery confusion and low mood, potentially helping patients leave the reco…

This study is testing whether adding a special digital app and web platform can improve depression care for people undergoing cancer treatment. It compares this tech-enhanced approach to the usual collaborative care methods. The goal is to see if the technology helps patients and…

This is a small pilot study to see if a new 6-session talk therapy program called Y-MIND is practical and acceptable for treating depression in young people aged 15-24 in Zimbabwe. The program is delivered by trained community counselors, not doctors. The main goal is to see if t…

This study aimed to explore whether using a virtual reality headset for guided mindfulness meditation could help reduce symptoms of pain, stress, anxiety, and depression. It planned to enroll 60 adults from UCLA and VA hospitals to try 15-minute VR sessions and track their sympto…

This study is testing whether a 12-week online group yoga program works as well as a proven online behavioral therapy for reducing depression symptoms in adults. Over 500 participants with depression were randomly assigned to receive either yoga or therapy sessions, with their sy…

This study aims to see if gentle electrical stimulation of a major nerve can help people who experience significant physical symptoms and excessive worry about their health. Sixty participants will try two different devices—one worn on the neck and one on the ear—for two weeks ea…

This study tested whether cancer patients could use a simple meditation app on their own to help manage feelings of anxiety and depression. Researchers enrolled 35 patients at MD Anderson Cancer Center who reported significant distress. Participants either used the meditation app…

This study is testing a brief, online therapy program designed to help LGBTQ+ adults who are experiencing anxiety or depression, particularly due to the social isolation of the COVID-19 pandemic. The program focuses on building social support and coping skills. Researchers are co…

This study is testing whether very short educational videos, called 'nano-learning,' can help older adults with muscle loss (sarcopenia) follow physical and nutritional advice and feel less depressed. It involves 180 older adults in a rural area who will watch these brief lessons…

This study is testing whether an 8-week online therapy program can help reduce depression in people living with a spinal cord injury. About 140 participants with depressive symptoms will be randomly assigned to either receive the therapy sessions or be placed on a waitlist for co…

This study is testing different digital coping strategies to help children manage anxiety and depression after their parents' divorce. It involves 144 children, aged 9 to 12, who are struggling with their parents' ongoing conflict. Researchers are comparing three online tools—tea…

This small, early-stage study is testing whether taking kava, a plant-based supplement, can safely help reduce anxiety and stress in people who have finished cancer treatment. Participants take either kava or a placebo pill for two weeks, then switch after a break. The study is c…

This small pilot study is testing whether a laughter yoga program is a practical and acceptable way to help children with autism spectrum disorder (ASD) feel less anxious and depressed, and to reduce stress for their parents. The study involves 66 child-parent pairs who will eith…

This study is testing whether a peer-led group program can help cancer survivors manage feelings of anxiety and depression after finishing their main cancer treatment. The program involves seven weekly group sessions led by trained non-professionals, focusing on building skills t…

This study is testing whether a smartphone app called OkeyMind can help reduce symptoms of social anxiety and depression in young people. The app provides automated education and meditation exercises over one month. Researchers will compare results from 180 participants using the…

This study is testing whether a 6-session coaching program called PRISM is practical and helpful for young adults (ages 18-39) with cancer who are experiencing moderate anxiety or depression. The program teaches skills like stress management and goal setting. Researchers are enro…

This remote study aimed to provide holistic education and pastoral counseling to help people manage stress and improve wellness in daily life. It was designed for specific unmarried Alaska Medicaid recipients who met religious and lifestyle criteria. The study was withdrawn befor…

This study is testing a mindfulness-based sleep therapy against a standard talk therapy for pregnant women who have both insomnia and depression. It aims to see which approach works better at improving sleep and mood during pregnancy and the first year after birth. The therapy se…

This study is testing a school-based program called INSPIRE, designed to help Indonesian teenagers better understand mental health, build resilience, and manage symptoms of depression and anxiety. Over 680 students and their parents will participate, with some receiving the 8-wee…

This study is testing whether cognitive behavioral therapy (CBT), a common talk therapy, is effective when provided by supervised but unlicensed trainees. It aims to see if this approach can help more people get access to proven mental health treatments for conditions like anxiet…

This study is testing if a complementary therapy called auricular point sticking (placing small seeds on specific ear points) can help women undergoing IVF. Researchers want to see if this technique reduces anxiety, improves sleep quality, and ultimately leads to better pregnancy…

This study is exploring whether two private, video-based Akashic Records sessions can help improve mental health. About 117 adults who have felt stressed, anxious, or down in the past year will complete surveys about their mood and resilience before and after the sessions. The go…

This study is testing whether a gentle, non-invasive brain stimulation technique can help ease depression and other non-motor symptoms in people with Parkinson's disease. Participants receive either real or sham stimulation for 30 minutes over 10 sessions. The main goal is to see…

This study aims to understand if depression makes it harder for teens and young adults with lupus to keep up with their medical care. Researchers are testing a specially designed mobile app to see if it's a helpful and practical tool for improving both mood and care engagement. T…

This study is testing whether inhaling nitrous oxide (laughing gas) can quickly reduce suicidal thoughts in hospitalized patients with severe depression. Fifty patients will receive either the gas or a placebo during up to six sessions while continuing their standard depression t…

This study aims to understand how lithium, a common treatment for bipolar disorder, changes the brain's wiring and activity. Researchers will use MRI brain scans on about 120 people with bipolar depression and healthy volunteers over 26 weeks to see how brain connections shift wi…

This study is observing over 19,000 older adults who previously participated in an aspirin trial to see if there are any delayed health effects years after stopping the medication. Researchers are primarily watching for long-term impacts on cancer, dementia, heart disease, and ph…

This study aims to find out if a simple brain wave test (EEG) can predict which people with depression will respond well to a non-invasive magnetic brain stimulation treatment called rTMS. Researchers are studying 30 people with depression, giving them the treatment and measuring…

This study uses brain scans to understand how TMS (transcranial magnetic stimulation) treatment affects brain connections in people with depression. Researchers will scan participants' brains before and after they receive standard TMS treatment for their depression. The goal is t…

This study aims to find brain scan patterns that predict whether veterans with hard-to-treat depression will respond to magnetic stimulation therapy. Researchers will use EEG brain scans taken before and during treatment to identify biomarkers that show who is likely to improve. …

This study aims to find brain signals that predict which depression treatments work best for individual patients. Researchers will use a special light-based brain scanner on 540 people receiving different treatments like ketamine, TMS, or antidepressants. The goal is to help doct…

This study aims to understand how physical therapists check for anxiety and depression in patients with long-term neck, shoulder, or back pain. Researchers interviewed 18 physical therapists to learn about their current practices, what makes it easier to screen for mental health,…

This study is testing a new team-based strategy to improve how a large children's hospital screens for depression. It involves 40 doctors and staff members. The goal is to make the screening process smoother and faster so children who need help get connected to mental health serv…

This study aims to understand if low testosterone levels might increase a person's risk of developing dementia, depression, or anxiety. Researchers will analyze existing genetic and health data from large public biobanks, not recruit new participants. The goal is to gather knowle…

This study aims to understand the link between depression and gum disease. Researchers are checking if taking antidepressants can reduce inflammation in the gums of people with chronic periodontitis. They enrolled 92 adults who already needed gum surgery to compare samples from t…

This study is testing whether a new, non-invasive ultrasound technique can safely change brain activity in areas linked to depression and anxiety. Researchers are enrolling 25 veterans to check for safety and see if the ultrasound can reduce activity in specific brain regions. Th…

This study is observing thousands of University of North Carolina alumni over many years to learn if personality traits like hostility and depression are connected to the development of heart disease. It is not testing a treatment; instead, it aims to gather knowledge by tracking…

This study aims to understand why some people with hard-to-treat depression respond to magnetic brain stimulation while others don't. Researchers are scanning the brains of 100 veterans before, during, and after they receive this standard treatment as part of their regular care. …