Mindfulness may rewire depressed brains, small study hints

NCT ID NCT05585775

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether mindfulness-based cognitive therapy (MBCT) can improve how the brain controls emotions in people with mild depression symptoms. 76 adults with depression in remission will be randomly assigned to either MBCT or a wellness program. Researchers will use computer tasks and surveys to measure changes in emotional thinking and mood over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Mindfulness-Based Cognitive Therapy (MBCT)

What this could lead to

If successful, this could reveal how MBCT works in the brain to ease depression, pointing toward more targeted treatments.

What could go wrong

This is a small, early-stage study focused on brain processes, not a direct treatment test. Results may not lead to new therapies or apply to everyone with depression.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Butler Hospital

    RECRUITING

    Providence, Rhode Island, 02906, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact