Mindfulness may rewire depressed brains, small study hints

NCT ID NCT05585775

Ongoing Knowledge-focused Sponsor: Butler Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study looks at whether mindfulness-based cognitive therapy (MBCT) can improve how the brain controls emotions in people with mild depression symptoms. 76 adults with depression in remission will be randomly assigned to either MBCT or a wellness program. Researchers will use computer tasks and surveys to measure changes in emotional thinking and mood over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mindfulness-Based Cognitive Therapy (MBCT)
What this could lead to: If successful, this could reveal how MBCT works in the brain to ease depression, pointing toward more targeted treatments.
What could go wrong: This is a small, early-stage study focused on brain processes, not a direct treatment test. Results may not lead to new therapies or apply to everyone with depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION DEPRESSION IN REMISSION DEPRESSIVE SYMPTOMS

Contacts and locations

Locations

Butler Hospital

Providence, Rhode Island, 02906, United States

More trials for these conditions

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