New online 'Behavioral Vaccine' aims to stop teen depression before it starts
NCT ID NCT05203198
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a self-guided online program called CATCH-IT, designed to prevent depression in teenagers who are at risk. Researchers are working with 400 teens aged 13-18 across four health systems to find the best way to deliver this program in primary care. The goal is to see if this low-cost, technology-based approach can reduce depressive symptoms and prevent full-blown depressive episodes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CATCH-IT (Competent Adulthood Transition with Cognitive-Behavioral, Humanistic and Interpersonal Training) - a self-directed, technology-based depression prevention program for adolescents and parents
What this could lead to
If successful, this could provide an effective, scalable strategy to prevent depression in teenagers, reducing the burden of mental illness.
What could go wrong
This is an optimization study, not a final test of effectiveness. The program is self-directed, so engagement may vary, and results may not apply to all teens or healthcare settings.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Advocate Aurora Health
Park Ridge, Illinois, 60068, United States
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Northshore University HealthSystem
Glenview, Illinois, 60026, United States
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UI Health
Chicago, Illinois, 60612, United States
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UT Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of Chicago Comer Children's Hospital
Chicago, Illinois, 60637, United States