Scientists probe Brain's depression hub with magnetic pulses
NCT ID NCT06266390
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how transcranial magnetic stimulation (TMS) affects a brain area called the subgenual cingulate, which is linked to depression. Researchers will give 54 adults with depression daily TMS sessions for 4-6 weeks, along with MRI scans, to see how this brain region responds. The goal is to understand the brain's reaction to TMS, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Transcranial Magnetic Stimulation (TMS)
What this could lead to
If successful, this could reveal how TMS works in the brain, leading to more targeted depression treatments.
What could go wrong
This is an early-stage, observational study with only 54 participants. It aims to understand brain activity, not to test a new treatment, so direct patient benefits are uncertain.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States