Can past stress block depression coping skills in teens?

NCT ID NCT04719897

Completed Knowledge-focused Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how stressful childhood experiences affect the ability of teens aged 12-15 with depression symptoms to learn a coping skill called cognitive restructuring. The skill helps teens notice and challenge negative thoughts. Researchers measured skill learning and retention over six months, along with stress responses. The goal is to understand how adversity impacts treatment success.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Repairing Thoughts cognitive restructuring module of FIRST cognitive behavioral therapy
What this could lead to: If successful, this study could help tailor depression treatments for teens based on their life experiences.
What could go wrong: This is an observational study with only 88 participants, so results may not apply to all teens. It does not test a new drug or cure.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVERSE CHILDHOOD EXPERIENCES DEPRESSION IN ADOLESCENCE

Contacts and locations

Locations

Western Psychiatric Institute and Clinic

Pittsburgh, Pennsylvania, 15213, United States

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