Can your bone doctor treat your depression?

NCT ID NCT05976347

Recruiting now Symptom relief Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether orthopaedic surgeons can safely screen for depression in patients recovering from a broken bone and offer treatment with common antidepressants like Prozac or Cymbalta. About 100 adults who score at least 5 on a depression questionnaire will be offered medication or a referral to behavioral health. The goal is to see if this approach improves depressive symptoms and is practical in a trauma clinic.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fluoxetine (Prozac) or Duloxetine (Cymbalta)
What this could lead to: If successful, this could show that orthopaedic surgeons can effectively treat depression after a serious injury, improving recovery and quality of life.
What could go wrong: This is a small pilot study (100 people) testing existing drugs, not a new breakthrough. Results may not apply to all patients, and antidepressants have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION

Contacts and locations

Locations

Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States

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