New combo targets tough pancreatic tumors

NCT ID NCT04172532

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 8 times

Summary

This study tests a drug called M3814 combined with a special type of radiation for people with locally advanced pancreatic cancer (cancer that has spread nearby but not to distant organs). The goal is to find the safest dose and see if the combination helps stop tumor growth longer than radiation alone. About 92 adults who have already had standard chemotherapy will take part.

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreatic adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA STAGE III PANCREATIC CANCER AJCC V8

Contacts and locations

Show contact details

Locations

City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States

Contact Email: •••••@•••••
City of Hope at Irvine Lennar
RECRUITING

Irvine, California, 92618, United States
Cooperman Barnabas Medical Center
RECRUITING

Livingston, New Jersey, 07039, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
ACTIVE_NOT_RECRUITING

Lebanon, New Hampshire, 03756, United States
HaysMed
RECRUITING

Hays, Kansas, 67601, United States
Huntsman Cancer Institute/University of Utah
ACTIVE_NOT_RECRUITING

Salt Lake City, Utah, 84112, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
ACTIVE_NOT_RECRUITING

New York, New York, 10016, United States
Lawrence Memorial Hospital
RECRUITING

Lawrence, Kansas, 66044, United States
Mercy Hospital Pittsburg
SUSPENDED

Pittsburg, Kansas, 66762, United States
Monmouth Medical Center
RECRUITING

Long Branch, New Jersey, 07740, United States
Montefiore Medical Center - Moses Campus
ACTIVE_NOT_RECRUITING

The Bronx, New York, 10467, United States
Montefiore Medical Center-Einstein Campus
ACTIVE_NOT_RECRUITING

The Bronx, New York, 10461, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
NYP/Weill Cornell Medical Center
RECRUITING

New York, New York, 10065, United States
Northwestern University
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60611, United States
Roswell Park Cancer Institute
ACTIVE_NOT_RECRUITING

Buffalo, New York, 14263, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States
Salina Regional Health Center
RECRUITING

Salina, Kansas, 67401, United States
Sibley Memorial Hospital
RECRUITING

Washington D.C., District of Columbia, 20016, United States
The University of Kansas Cancer Center - Olathe
RECRUITING

Olathe, Kansas, 66061, United States

Contact Email: •••••@•••••
UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
UCHealth University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University Health Truman Medical Center
RECRUITING

Kansas City, Missouri, 64108, United States
University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Lee's Summit
RECRUITING

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North
RECRUITING

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center at North Kansas City Hospital
SUSPENDED

North Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center-Overland Park
RECRUITING

Overland Park, Kansas, 66210, United States
University of Kansas Clinical Research Center
RECRUITING

Fairway, Kansas, 66205, United States
University of Kansas Health System Saint Francis Campus
RECRUITING

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Kentucky/Markey Cancer Center
WITHDRAWN

Lexington, Kentucky, 40536, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITING

Madison, Wisconsin, 53718, United States

Contact Email: •••••@•••••
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States

Contact Email: •••••@•••••
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Vanderbilt University/Ingram Cancer Center
SUSPENDED

Nashville, Tennessee, 37232, United States
Wake Forest Baptist Health - Wilkes Medical Center
ACTIVE_NOT_RECRUITING

Wilkesboro, North Carolina, 28659, United States
Wake Forest University Health Sciences
ACTIVE_NOT_RECRUITING

Winston-Salem, North Carolina, 27157, United States
Wake Forest University at Clemmons
ACTIVE_NOT_RECRUITING

Clemmons, North Carolina, 27012, United States
Wayne State University/Karmanos Cancer Institute
ACTIVE_NOT_RECRUITING

Detroit, Michigan, 48201, United States
Weisberg Cancer Treatment Center
ACTIVE_NOT_RECRUITING

Farmington Hills, Michigan, 48334, United States

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