New drug AB801 aims to boost chemo and immunotherapy in tough cancers
NCT ID NCT07619313
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests a new drug called AB801, which blocks a protein (AXL) that helps cancers grow and resist treatment. It is given alongside chemotherapy and immunotherapy to people with bile duct or pancreatic cancer that is either borderline resectable, locally advanced, or metastatic. The study will enroll 46 participants to check safety, side effects, and the best dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- AB801 (a drug that blocks the AXL protein on cancer cells)
- What this could lead to
- If successful, this could lead to a new combination treatment that makes chemotherapy and immunotherapy work better for bile duct and pancreatic cancers.
- What could go wrong
- This is a very early phase 1 trial with only 46 people, focused on safety and dosing. The drug may not work as hoped, and side effects from combining multiple treatments could be significant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, 90095, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a targeted pill outperform chemo for bile duct cancer?
- A sound wave that could expose hidden pancreatic cancer?
- Gene test may guide smarter chemo for pancreatic cancer