Smart testing after CAR t: could it spare kids from unneeded transplants?

NCT ID NCT05621291

Recruiting now Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 14, 2026 · Updated 35 times

Summary

This study tests whether regular blood and bone marrow tests using advanced DNA sequencing can better monitor children with B-cell acute lymphoblastic leukemia (B-ALL) after they achieve remission with CAR T therapy. The goal is to see if these tests can identify who is truly cured by CAR T alone and who might still need a stem cell transplant. Researchers will follow 60 participants aged 1 to 25 for two years, collecting samples every two weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Next-generation sequencing (NGS) testing
What this could lead to: If successful, this testing approach could help doctors decide which children need a stem cell transplant after CAR T therapy and which can be safely monitored without it.
What could go wrong: This is a small pilot study (60 participants) and the testing method is still experimental. It may not reliably predict relapse, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia B-cell acute lymphoblastic leukemia precursor B-cell acute lymphoblastic leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOBLASTIC LEUKEMIA B-ALL

Contacts and locations

Locations

Children's Healthcare of Atlanta
NOT_YET_RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hospital of Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Children's National Medical Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Dana-Farber/Boston Children s Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02115, United States
Fred Hutchinson Cancer Research Center
RECRUITING

Seattle, Washington, 98109, United States
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States
Seattle Children's, University of Washington
RECRUITING

Seattle, Washington, 98105, United States

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