Double immunotherapy may keep nasopharyngeal cancer at bay
NCT ID NCT06029270
First seen Jun 26, 2026 · Last updated Jul 24, 2026 · Updated 8 times
Summary
This phase II trial tests whether adding the immunotherapy drug relatlimab to standard nivolumab maintenance therapy can extend the time before cancer grows or spreads in patients with recurrent or metastatic nasopharyngeal cancer linked to Epstein-Barr virus. Participants first receive chemotherapy (cisplatin or carboplatin plus gemcitabine) with nivolumab, then are randomly assigned to continue nivolumab alone or with relatlimab. The study aims to enroll 156 patients and will compare progression-free survival between the two groups.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nivolumab and relatlimab (immunotherapy drugs)
- What this could lead to
- If successful, this could lead to a new maintenance treatment option that delays cancer progression in patients with recurrent or metastatic nasopharyngeal cancer.
- What could go wrong
- This is a phase II trial with only 156 participants, so results are preliminary. Adding relatlimab may increase side effects without improving outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Benefis Sletten Cancer Institute
RECRUITINGGreat Falls, Montana, 59405, United States
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Billings Clinic Cancer Center
RECRUITINGBillings, Montana, 59101, United States
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Bozeman Health Deaconess Hospital
RECRUITINGBozeman, Montana, 59715, United States
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Broadlawns Medical Center
RECRUITINGDes Moines, Iowa, 50314, United States
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Carle Cancer Center
RECRUITINGUrbana, Illinois, 61801, United States
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Carle Physician Group-Effingham
RECRUITINGEffingham, Illinois, 62401, United States
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Carle Physician Group-Mattoon/Charleston
RECRUITINGMattoon, Illinois, 61938, United States
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Carle at The Riverfront
RECRUITINGDanville, Illinois, 61832, United States
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Chinese University of Hong Kong-Prince of Wales Hospital
RECRUITINGShatin, Hong Kong
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Community Hospital of Anaconda
RECRUITINGAnaconda, Montana, 59711, United States
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Community Medical Center
RECRUITINGMissoula, Montana, 59804, United States
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Emory University Hospital Midtown
RECRUITINGAtlanta, Georgia, 30308, United States
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Heartland Oncology and Hematology LLP
SUSPENDEDCouncil Bluffs, Iowa, 51503, United States
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Iowa Methodist Medical Center
RECRUITINGDes Moines, Iowa, 50309, United States
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Kaiser Permanente Downtown Commons
RECRUITINGSacramento, California, 95814, United States
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Kaiser Permanente Dublin
RECRUITINGDublin, California, 94568, United States
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Kaiser Permanente Fresno Orchard Plaza
RECRUITINGFresno, California, 93720, United States
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Kaiser Permanente Medical Center - Santa Clara
RECRUITINGSanta Clara, California, 95051, United States
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Kaiser Permanente Moanalua Medical Center
RECRUITINGHonolulu, Hawaii, 96819, United States
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Kaiser Permanente San Leandro
RECRUITINGSan Leandro, California, 94577, United States
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Kaiser Permanente- Modesto MOB II
RECRUITINGModesto, California, 95356, United States
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Kaiser Permanente-Fremont
RECRUITINGFremont, California, 94538, United States
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Kaiser Permanente-Fresno
RECRUITINGFresno, California, 93720, United States
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Kaiser Permanente-Modesto
RECRUITINGModesto, California, 95356, United States
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Kaiser Permanente-Oakland
RECRUITINGOakland, California, 94611, United States
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Kaiser Permanente-Roseville
RECRUITINGRoseville, California, 95661, United States
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Kaiser Permanente-San Francisco
RECRUITINGSan Francisco, California, 94115, United States
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Kaiser Permanente-Santa Rosa
RECRUITINGSanta Rosa, California, 95403, United States
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Kaiser Permanente-Santa Teresa-San Jose
RECRUITINGSan Jose, California, 95119, United States
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Kaiser Permanente-South Sacramento
RECRUITINGSacramento, California, 95823, United States
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Kaiser Permanente-South San Francisco
RECRUITINGSouth San Francisco, California, 94080, United States
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Kaiser Permanente-Vallejo
RECRUITINGVallejo, California, 94589, United States
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Kaiser Permanente-Walnut Creek
RECRUITINGWalnut Creek, California, 94596, United States
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Kaiser San Rafael-Gallinas
RECRUITINGSan Rafael, California, 94903, United States
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Keck Medicine of USC Koreatown
RECRUITINGLos Angeles, California, 90020, United States
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Kootenai Clinic Cancer Services - Post Falls
RECRUITINGPost Falls, Idaho, 83854, United States
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Kootenai Clinic Cancer Services - Sandpoint
RECRUITINGSandpoint, Idaho, 83864, United States
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Kootenai Health - Coeur d'Alene
RECRUITINGCoeur d'Alene, Idaho, 83814, United States
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Logan Health Medical Center
RECRUITINGKalispell, Montana, 59901, United States
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Los Angeles General Medical Center
RECRUITINGLos Angeles, California, 90033, United States
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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Mercy Hospital Saint Louis
RECRUITINGSt Louis, Missouri, 63141, United States
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Mercy Hospital South
RECRUITINGSt Louis, Missouri, 63128, United States
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Mercy Medical Center - Des Moines
RECRUITINGDes Moines, Iowa, 50314, United States
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Methodist Jennie Edmundson Hospital
RECRUITINGCouncil Bluffs, Iowa, 51503, United States
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National Cancer Centre Singapore
RECRUITINGSingapore, 168583, Singapore
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National University Hospital Singapore
RECRUITINGSingapore, 119074, Singapore
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Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
SUSPENDEDOmaha, Nebraska, 68114, United States
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Nebraska Cancer Specialists/Oncology Hematology West PC - MEJ
RECRUITINGCouncil Bluffs, Iowa, 51503, United States
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Nebraska Methodist Hospital
RECRUITINGOmaha, Nebraska, 68114, United States
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Northwestern Medicine Cancer Center Delnor
RECRUITINGGeneva, Illinois, 60134, United States
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Northwestern Medicine Cancer Center Kishwaukee
RECRUITINGDeKalb, Illinois, 60115, United States
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Northwestern Medicine Cancer Center Warrenville
RECRUITINGWarrenville, Illinois, 60555, United States
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Northwestern Medicine Glenview Outpatient Center
RECRUITINGGlenview, Illinois, 60026, United States
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Northwestern Medicine Grayslake Outpatient Center
RECRUITINGGrayslake, Illinois, 60030, United States
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Northwestern Medicine Lake Forest Hospital
RECRUITINGLake Forest, Illinois, 60045, United States
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Northwestern Medicine Orland Park
RECRUITINGOrland Park, Illinois, 60462, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Oklahoma Cancer Specialists and Research Institute-Tulsa
SUSPENDEDTulsa, Oklahoma, 74146, United States
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Oncology Associates PC
SUSPENDEDOmaha, Nebraska, 68114, United States
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Peter MacCallum Cancer Centre
SUSPENDEDMelbourne, Victoria, 3000, Australia
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ProHealth D N Greenwald Center
RECRUITINGMukwonago, Wisconsin, 53149, United States
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ProHealth Oconomowoc Memorial Hospital
RECRUITINGOconomowoc, Wisconsin, 53066, United States
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ProHealth Waukesha Memorial Hospital
RECRUITINGWaukesha, Wisconsin, 53188, United States
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Providence Portland Medical Center
RECRUITINGPortland, Oregon, 97213, United States
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Providence Saint Vincent Medical Center
RECRUITINGPortland, Oregon, 97225, United States
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Saint Alphonsus Cancer Care Center-Boise
SUSPENDEDBoise, Idaho, 83706, United States
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Saint Alphonsus Cancer Care Center-Caldwell
SUSPENDEDCaldwell, Idaho, 83605, United States
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Saint Alphonsus Cancer Care Center-Nampa
SUSPENDEDNampa, Idaho, 83687, United States
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Saint Alphonsus Cancer Care Center-Ontario
SUSPENDEDOntario, Oregon, 97914, United States
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Saint Anthony Regional Hospital
RECRUITINGCarroll, Iowa, 51401, United States
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Stanford Cancer Institute Palo Alto
RECRUITINGPalo Alto, California, 94304, United States
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Swedish Medical Center-First Hill
RECRUITINGSeattle, Washington, 98122, United States
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UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITINGAnkeny, Iowa, 50023, United States
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UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITINGDes Moines, Iowa, 50309, United States
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UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITINGDes Moines, Iowa, 50314, United States
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UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITINGWaukee, Iowa, 50263, United States
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UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITINGClive, Iowa, 50325, United States
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UI Healthcare Mission Cancer and Blood - Fort Dodge
RECRUITINGFort Dodge, Iowa, 50501, United States
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USC / Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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USC Norris Oncology/Hematology-Newport Beach
RECRUITINGNewport Beach, California, 92663, United States
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UW Cancer Center at ProHealth Care
RECRUITINGWaukesha, Wisconsin, 53188, United States
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University Health Network-Princess Margaret Hospital
RECRUITINGToronto, Ontario, M5G 2M9, Canada
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University of California Davis Comprehensive Cancer Center
RECRUITINGSacramento, California, 95817, United States
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University of Cincinnati Cancer Center-UC Medical Center
ACTIVE_NOT_RECRUITINGCincinnati, Ohio, 45219, United States
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University of Cincinnati Cancer Center-West Chester
ACTIVE_NOT_RECRUITINGWest Chester, Ohio, 45069, United States
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University of Illinois
RECRUITINGChicago, Illinois, 60612, United States
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New triple therapy aims to control advanced nose cancer
- Immunotherapy plus chemo shows promise for Tough-to-Treat nasopharyngeal cancer
- Immunotherapy boost may improve outcomes in returning throat cancer
- New surgery technique could improve survival in recurrent throat cancer
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- Personalized vaccine takes on head and neck cancer in early trial