Second dose of targeted radiation may outperform standard drugs for stubborn gut tumors

NCT ID NCT05773274

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 11 times

Summary

This study tests whether a second round of targeted radiation therapy (177Lu-DOTATATE) works better than standard drugs (everolimus, sunitinib, or cabozantinib) for people with advanced neuroendocrine tumors of the digestive system that have spread and cannot be removed by surgery. About 100 adults whose tumors progressed after initial radiation treatment will be randomly assigned to receive either the radiation retreatment or one of the standard drugs. The main goal is to see which approach delays tumor growth longer.

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Conditions

The condition(s) this trial relates to.

digestive system neuroendocrine tumor, grade 1/2

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC DIGESTIVE SYSTEM NEUROENDOCRINE TUMOR G1 METASTATIC DIGESTIVE SYSTEM NEUROENDOCRINE TUMOR G2 UNRESECTABLE DIGESTIVE SYSTEM NEUROENDOCRINE TUMOR G1 UNRESECTABLE DIGESTIVE SYSTEM NEUROENDOCRINE TUMOR G2

Contacts and locations

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Locations

BCCA-Vancouver Cancer Centre
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Banner University Medical Center - Tucson
RECRUITING

Tucson, Arizona, 85719, United States
CancerCare Manitoba
SUSPENDED

Winnipeg, Manitoba, R3E 0V9, Canada
Doctor H. Bliss Murphy Cancer Centre
RECRUITING

St. John's, Newfoundland and Labrador, A1B 3V6, Canada
Henry Ford Hospital
ACTIVE_NOT_RECRUITING

Detroit, Michigan, 48202, United States
Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

Contact Email: •••••@•••••
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States
London Regional Cancer Program
RECRUITING

London, Ontario, N6A 4L6, Canada
Mayo Clinic Hospital in Arizona
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic in Florida
RECRUITING

Jacksonville, Florida, 32224-9980, United States
Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States
Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern Medicine Oak Brook
RECRUITING

Oak Brook, Illinois, 60523, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Odette Cancer Centre- Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Ohio State University Comprehensive Cancer Center
SUSPENDED

Columbus, Ohio, 43210, United States
Ottawa Hospital and Cancer Center-General Campus
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
UC Comprehensive Cancer Center at Silver Cross
RECRUITING

New Lenox, Illinois, 60451, United States

Contact Email: •••••@•••••
UCHealth University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING

Waukee, Iowa, 50263, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING

Clive, Iowa, 50325, United States
UM Sylvester Comprehensive Cancer Center at Aventura
RECRUITING

Aventura, Florida, 33180, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITING

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Kendall
RECRUITING

Miami, Florida, 33176, United States
UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITING

Plantation, Florida, 33324, United States
University of Alabama at Birmingham Cancer Center
SUSPENDED

Birmingham, Alabama, 35233, United States
University of Arizona Cancer Center-North Campus
RECRUITING

Tucson, Arizona, 85719, United States
University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
University of Chicago Medicine-Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States

Contact Email: •••••@•••••
University of Kentucky/Markey Cancer Center
ACTIVE_NOT_RECRUITING

Lexington, Kentucky, 40536, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
RECRUITING

North Miami, Florida, 33181, United States
University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States
University of Rochester
RECRUITING

Rochester, New York, 14642, United States

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