Scientists track families with rare gene mutation to uncover cancer clues

NCT ID NCT03830229

Recruiting now Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 12, 2026 · Updated 8 times

Summary

This study follows people with inherited BAP1 gene mutations, which raise the risk of mesothelioma and other cancers. Researchers will track participants over many years, collecting medical history, blood samples, and scans to understand how these mutations lead to cancer. The goal is to learn more about cancer development, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could reveal how BAP1 mutations lead to mesothelioma and other cancers, pointing toward better screening or prevention strategies.
What could go wrong: This is an observational study, not a treatment trial. It may not directly lead to new therapies, and results depend on long-term participation and data collection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

BAP1-related tumor predisposition syndrome mesothelioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FAMILIES MESOTHELIOMA

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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