New combo therapy aims to spare bladders in cancer patients

NCT ID NCT07061964

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 15 times

Summary

This phase II trial is testing whether giving the immunotherapy drug pembrolizumab along with radiation therapy after chemotherapy can help patients with muscle invasive bladder cancer avoid bladder removal surgery. About 111 participants who responded well to initial chemotherapy will receive the combination treatment. The goal is to see if this approach can keep the bladder cancer-free and improve survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pembrolizumab (immunotherapy) and radiation therapy
What this could lead to: If successful, this approach could allow many patients with muscle invasive bladder cancer to keep their bladder instead of having it surgically removed.
What could go wrong: This is a mid-stage trial with only 111 participants, so results may not apply to everyone. The combination may cause side effects like immune reactions or radiation damage, and the cancer could still return.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

infiltrating bladder urothelial carcinoma urinary bladder cancer Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MUSCLE INVASIVE BLADDER UROTHELIAL CARCINOMA STAGE II BLADDER CANCER AJCC V8 STAGE IIIA BLADDER CANCER AJCC V8

Contacts and locations

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Locations

Ascension All Saints Hospital-Spring Street-Racine
RECRUITING

Racine, Wisconsin, 53405, United States
Ascension Calumet Hospital-Chilton
RECRUITING

Chilton, Wisconsin, 53014, United States
Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
RECRUITING

Milwaukee, Wisconsin, 53211, United States
Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
RECRUITING

Mequon, Wisconsin, 53097, United States
Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh
RECRUITING

Oshkosh, Wisconsin, 54904, United States
Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
RECRUITING

Appleton, Wisconsin, 54915, United States
Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
RECRUITING

Brookfield, Wisconsin, 53045, United States
Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
RECRUITING

Wauwatosa, Wisconsin, 53226, United States
Asplundh Cancer Pavilion
RECRUITING

Willow Grove, Pennsylvania, 19090, United States

Contact Email: •••••@•••••
Banner MD Anderson Cancer Center
RECRUITING

Gilbert, Arizona, 85234, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

Contact Email: •••••@•••••
CTCA at Southeastern Regional Medical Center
RECRUITING

Newnan, Georgia, 30265, United States
Camden Clark Medical Center
RECRUITING

Parkersburg, West Virginia, 26101, United States

Contact Email: •••••@•••••
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States
Cancer Care and Hematology-Fort Collins
RECRUITING

Fort Collins, Colorado, 80528, United States
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
Cedars-Sinai Cancer - Tarzana
RECRUITING

Tarzana, California, 91356, United States
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States

Contact Email: •••••@•••••
City of Hope Antelope Valley
RECRUITING

Lancaster, California, 93534, United States

Contact Email: •••••@•••••
City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States

Contact Email: •••••@•••••
City of Hope Corona
RECRUITING

Corona, California, 92882, United States

Contact Email: •••••@•••••
City of Hope South Pasadena
RECRUITING

South Pasadena, California, 91030, United States

Contact Email: •••••@•••••
City of Hope Upland
RECRUITING

Upland, California, 91786, United States

Contact Email: •••••@•••••
City of Hope at Irvine Lennar
RECRUITING

Irvine, California, 92618, United States
Community Medical Center
SUSPENDED

Missoula, Montana, 59804, United States
Cooperman Barnabas Medical Center
RECRUITING

Livingston, New Jersey, 07039, United States
Crossroads Cancer Center
SUSPENDED

Effingham, Illinois, 62401, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Dartmouth Cancer Center - North
RECRUITING

Saint Johnsbury, Vermont, 05819, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States
Fairview Southdale Hospital
RECRUITING

Edina, Minnesota, 55435, United States
HSHS Saint Elizabeth's Hospital
RECRUITING

O'Fallon, Illinois, 62269, United States
Highlands Oncology Group
RECRUITING

Springdale, Arkansas, 72762, United States

Contact Email: •••••@•••••
Highlands Oncology Group - Fayetteville
RECRUITING

Fayetteville, Arkansas, 72703, United States

Contact Email: •••••@•••••
Highlands Oncology Group - Rogers
RECRUITING

Rogers, Arkansas, 72758, United States

Contact Email: •••••@•••••
Hunterdon Medical Center
RECRUITING

Flemington, New Jersey, 08822, United States
Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

Contact Email: •••••@•••••
Illinois CancerCare - Washington
RECRUITING

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington
RECRUITING

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton
RECRUITING

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage
RECRUITING

Carthage, Illinois, 62321, United States
Illinois CancerCare-Dixon
SUSPENDED

Dixon, Illinois, 61021, United States
Illinois CancerCare-Eureka
RECRUITING

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg
RECRUITING

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic
RECRUITING

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb
RECRUITING

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic
RECRUITING

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
RECRUITING

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria
RECRUITING

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru
RECRUITING

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton
RECRUITING

Princeton, Illinois, 61356, United States
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States
Jefferson Cherry Hill Hospital
RECRUITING

Cherry Hill, New Jersey, 08002, United States

Contact Email: •••••@•••••
Jersey City Medical Center
RECRUITING

Jersey City, New Jersey, 07302, United States
Kootenai Clinic Cancer Services - Post Falls
SUSPENDED

Post Falls, Idaho, 83854, United States
Kootenai Clinic Cancer Services - Sandpoint
SUSPENDED

Sandpoint, Idaho, 83864, United States
Kootenai Health - Coeur d'Alene
SUSPENDED

Coeur d'Alene, Idaho, 83814, United States
Los Angeles General Medical Center
RECRUITING

Los Angeles, California, 90033, United States

Contact Email: •••••@•••••
Mary Greeley Medical Center
RECRUITING

Ames, Iowa, 50010, United States
Mayo Clinic Hospital in Arizona
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic in Florida
SUSPENDED

Jacksonville, Florida, 32224-9980, United States
McFarland Clinic - Ames
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Boone
SUSPENDED

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson
SUSPENDED

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown
SUSPENDED

Marshalltown, Iowa, 50158, United States
McFarland Clinic - Trinity Cancer Center
SUSPENDED

Fort Dodge, Iowa, 50501, United States
Medical Center of the Rockies
RECRUITING

Loveland, Colorado, 80538, United States
Mercy Cancer Center-West Lakes
RECRUITING

Clive, Iowa, 50325, United States
Mercy Medical Center - Des Moines
RECRUITING

Des Moines, Iowa, 50314, United States
MetroHealth Medical Center
RECRUITING

Cleveland, Ohio, 44109, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States

Contact Email: •••••@•••••
Moffitt Cancer Center - McKinley Campus
RECRUITING

Tampa, Florida, 33612, United States

Contact Email: •••••@•••••
Moffitt Cancer Center at SouthShore
RECRUITING

Ruskin, Florida, 33570, United States

Contact Email: •••••@•••••
Moffitt Cancer Center at Wesley Chapel
RECRUITING

Wesley Chapel, Florida, 33544, United States

Contact Email: •••••@•••••
Moffitt Cancer Center-International Plaza
RECRUITING

Tampa, Florida, 33607, United States

Contact Email: •••••@•••••
NYP/Weill Cornell Medical Center
RECRUITING

New York, New York, 10065, United States
NorthShore University HealthSystem-Evanston Hospital
RECRUITING

Evanston, Illinois, 60201, United States
NorthShore University HealthSystem-Glenbrook Hospital
RECRUITING

Glenview, Illinois, 60026, United States
NorthShore University HealthSystem-Highland Park Hospital
RECRUITING

Highland Park, Illinois, 60035, United States
Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States
Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern Medicine Glenview Outpatient Center
RECRUITING

Glenview, Illinois, 60026, United States
Northwestern Medicine Grayslake Outpatient Center
RECRUITING

Grayslake, Illinois, 60030, United States
Northwestern Medicine Lake Forest Hospital
RECRUITING

Lake Forest, Illinois, 60045, United States

Contact Email: •••••@•••••
Northwestern Medicine Oak Brook
RECRUITING

Oak Brook, Illinois, 60523, United States
Northwestern Medicine Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
OSF Saint Francis Medical Center
RECRUITING

Peoria, Illinois, 61637, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
RECRUITING

Peoria, Illinois, 61615, United States
OSF Saint Joseph Medical Center
RECRUITING

Bloomington, Illinois, 61701, United States
Ochsner Medical Center Jefferson
RECRUITING

New Orleans, Louisiana, 70121, United States
Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
Parkland Memorial Hospital
RECRUITING

Dallas, Texas, 75235, United States

Contact Email: •••••@•••••
Poudre Valley Hospital
RECRUITING

Fort Collins, Colorado, 80524, United States
Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
RECRUITING

Franklin, Wisconsin, 53132, United States
Rush-Copley Medical Center
RECRUITING

Aurora, Illinois, 60504, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States
Saint Vincent Hospital Cancer Center Green Bay
RECRUITING

Green Bay, Wisconsin, 54301, United States
Saint Vincent Hospital Cancer Center at Oconto Falls
RECRUITING

Oconto Falls, Wisconsin, 54154, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
RECRUITING

Green Bay, Wisconsin, 54303, United States
Saint Vincent Hospital Cancer Center at Sheboygan
RECRUITING

Sheboygan, Wisconsin, 53081, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
RECRUITING

Sturgeon Bay, Wisconsin, 54235-1495, United States
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Email: •••••@•••••
Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

Contact Email: •••••@•••••
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
Scott and White Memorial Hospital
RECRUITING

Temple, Texas, 76508, United States
Shaw Cancer Center
RECRUITING

Edwards, Colorado, 81632, United States
Sidney Kimmel Cancer Center Washington Township
RECRUITING

Sewell, New Jersey, 08080, United States

Contact Email: •••••@•••••
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital
RECRUITING

Springfield, Illinois, 62781, United States
Stony Brook University Medical Center
RECRUITING

Stony Brook, New York, 11794, United States
Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States
The Iowa Clinic PC
RECRUITING

West Des Moines, Iowa, 50266, United States
The James Graham Brown Cancer Center at University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
The New York Hospital Medical Center of Queens
RECRUITING

Flushing, New York, 11355, United States
The West Clinic - Wolf River
RECRUITING

Germantown, Tennessee, 38138, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Email: •••••@•••••
Tower Cancer Research Foundation
RECRUITING

Beverly Hills, California, 90211, United States

Contact Email: •••••@•••••
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
UCHealth - Cherry Creek
RECRUITING

Denver, Colorado, 80206, United States
UCHealth Greeley Hospital
RECRUITING

Greeley, Colorado, 80631, United States
UCHealth Highlands Ranch Hospital
RECRUITING

Highlands Ranch, Colorado, 80129, United States
UCHealth Lone Tree Health Center
RECRUITING

Lone Tree, Colorado, 80124, United States
UCHealth University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING

Waukee, Iowa, 50263, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING

Clive, Iowa, 50325, United States
UMass Memorial Medical Center - University Campus
RECRUITING

Worcester, Massachusetts, 01655, United States

Contact Email: •••••@•••••
USC / Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
UT Southwestern Clinical Center at Richardson/Plano
RECRUITING

Richardson, Texas, 75080, United States
UT Southwestern Simmons Cancer Center - RedBird
RECRUITING

Dallas, Texas, 75237, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Email: •••••@•••••
University Medical Center New Orleans
RECRUITING

New Orleans, Louisiana, 70112, United States
University of Alabama at Birmingham Cancer Center
RECRUITING

Birmingham, Alabama, 35233, United States
University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of Cincinnati Cancer Center-UC Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States

Contact Email: •••••@•••••
University of Cincinnati Cancer Center-West Chester
RECRUITING

West Chester, Ohio, 45069, United States

Contact Email: •••••@•••••
University of Kentucky/Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania/Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••
University of Texas Health Science Center at San Antonio
RECRUITING

San Antonio, Texas, 78229, United States

Contact Email: •••••@•••••
UofL Health Medical Center Northeast
RECRUITING

Louisville, Kentucky, 40245, United States

Contact Email: •••••@•••••
VCU Massey Cancer Center at Stony Point
RECRUITING

Richmond, Virginia, 23235, United States
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
West Virginia University Healthcare
RECRUITING

Morgantown, West Virginia, 26506, United States

Contact Email: •••••@•••••

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