Needle-Sized device could reveal which bladder cancer drug works best
NCT ID NCT06204614
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage study tests a tiny implantable device that releases very small amounts of several cancer drugs directly into bladder tumors. The goal is to see if the device is safe and can help doctors figure out which drugs kill the tumor best. Only 18 people with muscle-invasive bladder cancer who are already scheduled for bladder removal surgery will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- implantable microdevice releasing microdoses of methotrexate, carboplatin, avelumab, and paclitaxel
- What this could lead to
- If successful, this could lead to a way to test multiple cancer drugs directly in a patient's tumor, helping doctors choose the most effective treatment without exposing the whole body to side effects.
- What could go wrong
- This is a very early, small study with only 18 people, focused on safety and feasibility, not on curing cancer. The device may not work as hoped, and there is a small risk of side effects from the procedure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MUSCLE INVASIVE BLADDER UROTHELIAL CARCINOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A simple blood draw could detect bladder Cancer's return — a trial puts it to the test
- New combination aims to save bladders in Muscle-Invasive cancer
- Bladder cancer radiation trial halted early – only 2 patients enrolled
- Could fewer radiation sessions be just as effective for bladder cancer?
- Gene therapy joins forces with chemo and immunotherapy to fight bladder cancer
- New hope for bladder cancer patients who can't have standard chemo