Immunotherapy boost before surgery may improve sinonasal cancer outcomes
NCT ID NCT07281417
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether adding the immunotherapy drug cemiplimab to standard chemotherapy before surgery helps people with sinonasal squamous cell carcinoma. About 108 participants will be randomly assigned to receive either chemo alone or chemo plus cemiplimab before their operation. The study aims to see if the combination improves event-free survival and tumor shrinkage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cemiplimab (an immunotherapy drug) plus carboplatin and paclitaxel (chemotherapy drugs)
What this could lead to
If it works, this could lead to a more effective treatment before surgery for sinonasal cancer, potentially reducing recurrence and improving survival.
What could go wrong
This is a phase 2 trial with only 108 participants, so results are preliminary. Adding immunotherapy to chemo may increase side effects, and the benefit over chemo alone is not yet proven.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Emory University Hospital Midtown
RECRUITINGAtlanta, Georgia, 30308, United States
Contact
Contact Phone: •••-•••-••••
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Ohio State University Comprehensive Cancer Center LAO
RECRUITINGColumbus, Ohio, 43210, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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UC Irvine Health/Chao Family Comprehensive Cancer Center
SUSPENDEDOrange, California, 92868, United States
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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
SUSPENDEDIrvine, California, 92612, United States
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University of Kentucky/Markey Cancer Center
SUSPENDEDLexington, Kentucky, 40536, United States