Immunotherapy boost before surgery may improve sinonasal cancer outcomes

NCT ID NCT07281417

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 8 times

Summary

This phase 2 trial tests whether adding the immunotherapy drug cemiplimab to standard chemotherapy before surgery helps people with sinonasal squamous cell carcinoma. About 108 participants will be randomly assigned to receive either chemo alone or chemo plus cemiplimab before their operation. The study aims to see if the combination improves event-free survival and tumor shrinkage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cemiplimab (an immunotherapy drug) plus carboplatin and paclitaxel (chemotherapy drugs)
What this could lead to: If it works, this could lead to a more effective treatment before surgery for sinonasal cancer, potentially reducing recurrence and improving survival.
What could go wrong: This is a phase 2 trial with only 108 participants, so results are preliminary. Adding immunotherapy to chemo may increase side effects, and the benefit over chemo alone is not yet proven.

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Conditions

The condition(s) this trial relates to.

nasal cavity and paranasal sinus carcinoma non-keratinizing sinonasal squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SINONASAL SQUAMOUS CELL CARCINOMA STAGE III SINONASAL CANCER AJCC V8 STAGE IVA SINONASAL CANCER AJCC V8 STAGE IVB SINONASAL CANCER AJCC V8

Contacts and locations

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Locations

Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of Kentucky/Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact Email: •••••@•••••

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