New drug combo aims to outsmart resistant ovarian cancer

NCT ID NCT04633239

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 3 times

Summary

This early-phase trial is testing whether combining two targeted drugs—abemaciclib and olaparib—can help women with ovarian cancer that has stopped responding to platinum-based chemotherapy. The study will enroll 42 participants to find the safest dose and check for side effects. Researchers hope the drug pair can slow or shrink tumors by blocking cancer cell growth and DNA repair.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: abemaciclib and olaparib
What this could lead to: If it works, this could lead to a new treatment option for women with ovarian cancer that has stopped responding to standard platinum-based chemotherapy.
What could go wrong: This is an early phase 1 trial with only 42 participants, so it is too small to prove effectiveness. The combination may cause significant side effects or fail to control the cancer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ovarian carcinoma ovarian serous adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT OVARIAN HIGH GRADE SEROUS ADENOCARCINOMA RECURRENT PLATINUM-RESISTANT OVARIAN CARCINOMA

Contacts and locations

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Locations

Los Angeles General Medical Center
RECRUITING

Los Angeles, California, 90033, United States

Contact Email: •••••@•••••
Mayo Clinic Hospital in Arizona
ACTIVE_NOT_RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic in Florida
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32224-9980, United States
Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
TERMINATED

New York, New York, 10032, United States
Northwestern University
ACTIVE_NOT_RECRUITING

Chicago, Illinois, 60611, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Email: •••••@•••••
UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

Contact Email: •••••@•••••
UM Sylvester Comprehensive Cancer Center at Coral Gables
ACTIVE_NOT_RECRUITING

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
ACTIVE_NOT_RECRUITING

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Plantation
ACTIVE_NOT_RECRUITING

Plantation, Florida, 33324, United States
USC / Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
University of Kansas Cancer Center
SUSPENDED

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Lee's Summit
SUSPENDED

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North
SUSPENDED

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center at North Kansas City Hospital
SUSPENDED

North Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center-Overland Park
SUSPENDED

Overland Park, Kansas, 66210, United States
University of Kansas Clinical Research Center
RECRUITING

Fairway, Kansas, 66205, United States
University of Kansas Hospital-Indian Creek Campus
SUSPENDED

Overland Park, Kansas, 66211, United States
University of Kansas Hospital-Westwood Cancer Center
SUSPENDED

Westwood, Kansas, 66205, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
ACTIVE_NOT_RECRUITING

Miami, Florida, 33136, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact Email: •••••@•••••
Vanderbilt University/Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States
Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States

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