New drug combo aims to outsmart resistant ovarian cancer
NCT ID NCT04633239
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 43 times
Summary
This early-phase trial is testing whether combining two targeted drugs—abemaciclib and olaparib—can help women with ovarian cancer that has stopped responding to platinum-based chemotherapy. The study will enroll 42 participants to find the safest dose and check for side effects. Researchers hope the drug pair can slow or shrink tumors by blocking cancer cell growth and DNA repair.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Los Angeles General Medical Center
RECRUITINGLos Angeles, California, 90033, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic Hospital in Arizona
ACTIVE_NOT_RECRUITINGPhoenix, Arizona, 85054, United States
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Mayo Clinic in Florida
ACTIVE_NOT_RECRUITINGJacksonville, Florida, 32224-9980, United States
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact
Contact Phone: •••-•••-••••
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
TERMINATEDNew York, New York, 10032, United States
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Northwestern University
ACTIVE_NOT_RECRUITINGChicago, Illinois, 60611, United States
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Thomas Jefferson University Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITINGOrange, California, 92868, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITINGIrvine, California, 92612, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UM Sylvester Comprehensive Cancer Center at Coral Gables
ACTIVE_NOT_RECRUITINGCoral Gables, Florida, 33146, United States
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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
ACTIVE_NOT_RECRUITINGDeerfield Beach, Florida, 33442, United States
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UM Sylvester Comprehensive Cancer Center at Plantation
ACTIVE_NOT_RECRUITINGPlantation, Florida, 33324, United States
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USC / Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
Contact
Contact Phone: •••-•••-••••
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University of Kansas Cancer Center
SUSPENDEDKansas City, Kansas, 66160, United States
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University of Kansas Cancer Center - Lee's Summit
SUSPENDEDLee's Summit, Missouri, 64064, United States
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University of Kansas Cancer Center - North
SUSPENDEDKansas City, Missouri, 64154, United States
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University of Kansas Cancer Center at North Kansas City Hospital
SUSPENDEDNorth Kansas City, Missouri, 64116, United States
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University of Kansas Cancer Center-Overland Park
SUSPENDEDOverland Park, Kansas, 66210, United States
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University of Kansas Clinical Research Center
RECRUITINGFairway, Kansas, 66205, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kansas Hospital-Indian Creek Campus
SUSPENDEDOverland Park, Kansas, 66211, United States
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University of Kansas Hospital-Westwood Cancer Center
SUSPENDEDWestwood, Kansas, 66205, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
ACTIVE_NOT_RECRUITINGMiami, Florida, 33136, United States
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Virginia Cancer Center
RECRUITINGCharlottesville, Virginia, 22908, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vanderbilt University/Ingram Cancer Center
RECRUITINGNashville, Tennessee, 37232, United States
Contact
Contact Phone: •••-•••-••••
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Wake Forest University Health Sciences
RECRUITINGWinston-Salem, North Carolina, 27157, United States
Contact
Contact Phone: •••-•••-••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
abemaciclib and olaparib
What this could lead to
If it works, this could lead to a new treatment option for women with ovarian cancer that has stopped responding to standard platinum-based chemotherapy.
What could go wrong
This is an early phase 1 trial with only 42 participants, so it is too small to prove effectiveness. The combination may cause significant side effects or fail to control the cancer.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.