Immunotherapy duo shows promise for Tough-to-Treat uterine cancer

NCT ID NCT05112601

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 12 times

Summary

This phase II trial is testing whether combining two immunotherapy drugs, nivolumab and ipilimumab, works better than nivolumab alone for women with recurrent endometrial cancer that has a specific DNA repair defect (dMMR). About 81 participants will receive either the combination or single drug. The goal is to see if the combo can shrink tumors or slow cancer growth better than the single drug alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nivolumab and ipilimumab (immunotherapy drugs)
What this could lead to: If successful, this could provide a more effective treatment option for recurrent endometrial cancer with a specific genetic feature, potentially shrinking tumors and extending life.
What could go wrong: This is a phase II trial with only 81 participants, so results are preliminary. The combination may not be more effective than nivolumab alone and could cause additional side effects like immune-related inflammation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Carcinoma, Endometrioid endometrial carcinoma endometrial clear cell adenocarcinoma endometrial endometrioid adenocarcinoma endometrial mixed adenocarcinoma endometrial mucinous adenocarcinoma endometrial undifferentiated carcinoma endometrioid adenocarcinoma endometrium adenocarcinoma endometrium neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL ADENOCARCINOMA ENDOMETRIAL CLEAR CELL ADENOCARCINOMA ENDOMETRIAL DEDIFFERENTIATED CARCINOMA ENDOMETRIAL ENDOMETRIOID ADENOCARCINOMA ENDOMETRIAL MIXED CELL ADENOCARCINOMA ENDOMETRIAL MUCINOUS ADENOCARCINOMA ENDOMETRIAL UNDIFFERENTIATED CARCINOMA ENDOMETRIOID ADENOCARCINOMA RECURRENT ENDOMETRIAL CARCINOMA

Contacts and locations

Show contact details

Locations

Abbott-Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States
Arnold Palmer Cancer Center Medical Oncology Norwin
RECRUITING

N. Huntingdon, Pennsylvania, 15642, United States

Contact Email: •••••@•••••
Augusta University Medical Center
SUSPENDED

Augusta, Georgia, 30912, United States
Beacon Kalamazoo Cancer Center
RECRUITING

Kalamazoo, Michigan, 49009, United States
Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

Contact Email: •••••@•••••
Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

Contact Email: •••••@•••••
Bronson Battle Creek
RECRUITING

Battle Creek, Michigan, 49017, United States
Bronson Methodist Hospital
RECRUITING

Kalamazoo, Michigan, 49007, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores
SUSPENDED

Norton Shores, Michigan, 49444, United States
Carle BroMenn Medical Center
RECRUITING

Normal, Illinois, 61761, United States

Contact Email: •••••@•••••
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Cancer Institute Normal
RECRUITING

Normal, Illinois, 61761, United States

Contact Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
Case Western Reserve University
RECRUITING

Cleveland, Ohio, 44106, United States

Contact Email: •••••@•••••
Cleveland Clinic Cancer Center/Fairview Hospital
RECRUITING

Cleveland, Ohio, 44111, United States

Contact Email: •••••@•••••
Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195, United States

Contact Email: •••••@•••••
Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

Contact Email: •••••@•••••
Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

Contact Email: •••••@•••••
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
RECRUITING

Saint Joseph, Michigan, 49085, United States
Corewell Health Lakeland Hospitals - Niles Hospital
RECRUITING

Niles, Michigan, 49120, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
RECRUITING

Saint Joseph, Michigan, 49085, United States
Corewell Health Reed City Hospital
RECRUITING

Reed City, Michigan, 49677, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Duke Women's Cancer Care Raleigh
RECRUITING

Raleigh, North Carolina, 27607, United States
Duluth Clinic Ashland
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact Email: •••••@•••••
Essentia Health - Deer River Clinic
RECRUITING

Deer River, Minnesota, 56636, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center-South University Clinic
RECRUITING

Fargo, North Dakota, 58103, United States

Contact Email: •••••@•••••
Essentia Health Hibbing Clinic
RECRUITING

Hibbing, Minnesota, 55746, United States
Essentia Health Sandstone
RECRUITING

Sandstone, Minnesota, 55072, United States

Contact Email: •••••@•••••
Essentia Health Virginia Clinic
RECRUITING

Virginia, Minnesota, 55792, United States

Contact Email: •••••@•••••
Fairview Southdale Hospital
RECRUITING

Edina, Minnesota, 55435, United States
Fred Hutchinson Cancer Center
ACTIVE_NOT_RECRUITING

Seattle, Washington, 98109, United States
Geauga Hospital
RECRUITING

Chardon, Ohio, 44024, United States

Contact Email: •••••@•••••
Good Samaritan Hospital - Cincinnati
RECRUITING

Cincinnati, Ohio, 45220, United States

Contact Email: •••••@•••••
Henrico Doctor's Hospital
RECRUITING

Richmond, Virginia, 23229, United States
Hillcrest Hospital Cancer Center
RECRUITING

Mayfield Heights, Ohio, 44124, United States

Contact Email: •••••@•••••
IRMC Cancer Center
RECRUITING

Indiana, Pennsylvania, 15701, United States
IU Health North Hospital
SUSPENDED

Carmel, Indiana, 46032, United States
Indiana University/Melvin and Bren Simon Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States

Contact Email: •••••@•••••
Intermountain Health West End Clinic
RECRUITING

Billings, Montana, 59106, United States
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

Contact Email: •••••@•••••
Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

Contact Email: •••••@•••••
Logan Health Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

Contact Email: •••••@•••••
MU Health - University Hospital/Ellis Fischel Cancer Center
RECRUITING

Columbia, Missouri, 65212, United States
MaineHealth Maine Medical Center- Scarborough
RECRUITING

Scarborough, Maine, 04074, United States

Contact Email: •••••@•••••
Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States
Miami Valley Hospital South
RECRUITING

Centerville, Ohio, 45459, United States

Contact Email: •••••@•••••
Miller-Dwan Hospital
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Minnesota Oncology - Edina
RECRUITING

Edina, Minnesota, 55435, United States
Munson Medical Center
RECRUITING

Traverse City, Michigan, 49684, United States
Nebraska Methodist Hospital
RECRUITING

Omaha, Nebraska, 68114, United States
Northwest Cancer Center - Crown Point
RECRUITING

Crown Point, Indiana, 46307, United States

Contact Email: •••••@•••••
Northwest Cancer Center - Hobart
RECRUITING

Hobart, Indiana, 46342, United States
Northwest Cancer Center - Valparaiso
RECRUITING

Valparaiso, Indiana, 46383, United States

Contact Email: •••••@•••••
Northwest Oncology LLC
RECRUITING

Dyer, Indiana, 46311, United States
Northwest Wisconsin Cancer Center
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact Email: •••••@•••••
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Oklahoma Cancer Specialists and Research Institute-Tulsa
RECRUITING

Tulsa, Oklahoma, 74146, United States
Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
Parkland Memorial Hospital
RECRUITING

Dallas, Texas, 75235, United States

Contact Email: •••••@•••••
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact Email: •••••@•••••
Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

Contact Email: •••••@•••••
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Roswell Park Cancer Institute
ACTIVE_NOT_RECRUITING

Buffalo, New York, 14263, United States
Saint Alphonsus Cancer Care Center-Boise
SUSPENDED

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell
SUSPENDED

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa
SUSPENDED

Nampa, Idaho, 83687, United States
Saint Alphonsus Cancer Care Center-Ontario
SUSPENDED

Ontario, Oregon, 97914, United States
Saint Catherine Hospital
RECRUITING

Indianapolis, Indiana, 46312, United States
Saint Francis Regional Medical Center
RECRUITING

Shakopee, Minnesota, 55379, United States
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83687, United States
Saint Mary Medical Center
RECRUITING

Hobart, Indiana, 46342, United States

Contact Email: •••••@•••••
Saint Vincent Frontier Cancer Center
RECRUITING

Billings, Montana, 59102, United States
State University of New York Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States
Swedish Cancer Institute-Edmonds
RECRUITING

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah
RECRUITING

Issaquah, Washington, 98029, United States
Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States
The Community Hospital
RECRUITING

Munster, Indiana, 46321, United States
The James Graham Brown Cancer Center at University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
Trinity Health Grand Rapids Hospital
SUSPENDED

Grand Rapids, Michigan, 49503, United States
Trinity Health Muskegon Hospital
SUSPENDED

Muskegon, Michigan, 49444, United States
UH Seidman Cancer Center at Lake Health Mentor Campus
RECRUITING

Mentor, Ohio, 44060, United States

Contact Email: •••••@•••••
UH Seidman Cancer Center at Saint John Medical Center
RECRUITING

Westlake, Ohio, 44145, United States

Contact Email: •••••@•••••
UHHS-Chagrin Highlands Medical Center
RECRUITING

Beachwood, Ohio, 44122, United States

Contact Email: •••••@•••••
UPMC Cancer Center at UPMC Horizon
RECRUITING

Farrell, Pennsylvania, 16121, United States
UPMC Cancer Center at UPMC McKeesport
RECRUITING

McKeesport, Pennsylvania, 15132, United States
UPMC Cancer Center at UPMC Northwest
RECRUITING

Seneca, Pennsylvania, 16346, United States
UPMC Cancer Center-Natrona Heights
RECRUITING

Natrona Heights, Pennsylvania, 15065, United States
UPMC Cancer Center-Washington
RECRUITING

Washington, Pennsylvania, 15301, United States
UPMC Cancer Centers - Arnold Palmer Pavilion
RECRUITING

Greensburg, Pennsylvania, 15601, United States
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UPMC Hillman Cancer Center - Monroeville
RECRUITING

Monroeville, Pennsylvania, 15146, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center - New Castle
RECRUITING

New Castle, Pennsylvania, 16105, United States
UPMC Hillman Cancer Center - Part of Frick Hospital
RECRUITING

Mount Pleasant, Pennsylvania, 15666, United States
UPMC Hillman Cancer Center - Passavant - Cranberry
RECRUITING

Cranberry Township, Pennsylvania, 16066, United States
UPMC Hillman Cancer Center Erie
RECRUITING

Erie, Pennsylvania, 16505, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center at Butler Health System
RECRUITING

Butler, Pennsylvania, 16001, United States
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
RECRUITING

Mechanicsburg, Pennsylvania, 17050, United States
UPMC Hillman Cancer Center in Coraopolis
RECRUITING

Moon Township, Pennsylvania, 15108, United States
UPMC West Mifflin-Cancer Center Jefferson
RECRUITING

West Mifflin, Pennsylvania, 15122, United States
UPMC-Heritage Valley Health System Beaver
RECRUITING

Beaver, Pennsylvania, 15009, United States
UPMC-Johnstown/John P. Murtha Regional Cancer Center
RECRUITING

Johnstown, Pennsylvania, 15901, United States
UPMC-Magee Womens Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
UPMC-Mercy Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15219, United States
UPMC-Passavant Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15237, United States
UPMC-Saint Clair Hospital Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15243, United States
UPMC-Saint Margaret
RECRUITING

Pittsburgh, Pennsylvania, 15215, United States
UT Southwestern Clinical Center at Richardson/Plano
RECRUITING

Richardson, Texas, 75080, United States
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Email: •••••@•••••
United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States
University Cancer and Blood Center LLC
SUSPENDED

Athens, Georgia, 30607, United States
University Hospitals Parma Medical Center
RECRUITING

Parma, Ohio, 44129, United States

Contact Email: •••••@•••••
University of Alabama at Birmingham Cancer Center
RECRUITING

Birmingham, Alabama, 35233, United States
University of Illinois
SUSPENDED

Chicago, Illinois, 60612, United States
University of Iowa/Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States
University of Michigan Health - West
RECRUITING

Wyoming, Michigan, 49519, United States
University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Rochester
RECRUITING

Rochester, New York, 14642, United States
University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact Email: •••••@•••••
UofL Health Medical Center Northeast
RECRUITING

Louisville, Kentucky, 40245, United States

Contact Email: •••••@•••••
VCU Massey Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Richmond, Virginia, 23298, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
West Michigan Cancer Center
RECRUITING

Kalamazoo, Michigan, 49007, United States
Wilmot Cancer Institute at Webster
RECRUITING

Webster, New York, 14580, United States

Contact Email: •••••@•••••
Women and Infants Hospital
RECRUITING

Providence, Rhode Island, 02905, United States
Women's Cancer Center of Nevada
RECRUITING

Las Vegas, Nevada, 89106, United States
Women's Diagnostic Center - Munster
RECRUITING

Munster, Indiana, 46321, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.