New drug cocktail targets metastatic colorectal cancer in early trial

NCT ID NCT06696768

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 4 times

Summary

This early-phase trial is testing whether adding an experimental drug called CA-4948 to standard chemotherapy (FOLFOX) and a targeted therapy (bevacizumab) is safe for people with metastatic colorectal cancer. About 24 adults whose cancer has spread and cannot be surgically removed will take part. The main goals are to find the best dose and identify any side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CA-4948 (emavusertib) combined with FOLFOX (fluorouracil, leucovorin, oxaliplatin) and bevacizumab
What this could lead to: If this combination proves safe and effective, it could offer a new frontline treatment option for people with metastatic colorectal cancer.
What could go wrong: This is a very early Phase I trial with only 24 participants, focused on safety and dosing. It is too small to prove effectiveness, and the drug combination may cause significant side effects or fail to improve outcomes.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC COLORECTAL ADENOCARCINOMA STAGE III COLORECTAL CANCER AJCC V8 STAGE IV COLORECTAL CANCER AJCC V8 UNRESECTABLE COLORECTAL ADENOCARCINOMA

Contacts and locations

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Locations

Memorial Hospital East
RECRUITING

Shiloh, Illinois, 62269, United States
Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

Contact Email: •••••@•••••
Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

Contact Email: •••••@•••••
Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

Contact Email: •••••@•••••
UF Health Cancer Institute - Gainesville
RECRUITING

Gainesville, Florida, 32610, United States

Contact Email: •••••@•••••
University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Clinical Research Center
RECRUITING

Fairway, Kansas, 66205, United States
University of Kansas Hospital-Indian Creek Campus
RECRUITING

Overland Park, Kansas, 66211, United States
University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Vanderbilt University/Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••

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