New drug cocktail ViPOR targets tough lymphomas in phase II trial

NCT ID NCT06649812

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 7 times

Summary

This phase II trial is testing a combination of five drugs (venetoclax, ibrutinib, prednisone, obinutuzumab, and lenalidomide, called ViPOR) in people with certain aggressive B-cell lymphomas that have come back or not responded to treatment. The study aims to see how many patients achieve a complete response, meaning all signs of cancer disappear. About 120 adults will take part, and the trial is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ViPOR (venetoclax, ibrutinib, prednisone, obinutuzumab, and lenalidomide)
What this could lead to: If successful, this could offer a new treatment option for people with hard-to-treat lymphomas that have come back or not responded to prior therapy.
What could go wrong: This is a phase II trial with only 120 participants, so results are preliminary. The drug combination may cause side effects and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma diffuse large B-cell lymphoma germinal center B-cell type high grade B-cell lymphoma high grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement relapsed/refractory diffuse large B-cell lymphoma T-cell/histiocyte rich large B cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH GRADE B-CELL LYMPHOMA WITH MYC AND BCL6 REARRANGEMENTS RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA GERMINAL CENTER B-CELL TYPE RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED RECURRENT HIGH GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 OR BCL6 REARRANGEMENTS RECURRENT HIGH GRADE B-CELL LYMPHOMA WITH MYC, BCL2, AND BCL6 REARRANGEMENTS RECURRENT HIGH GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED RECURRENT T-CELL/HISTIOCYTE-RICH LARGE B-CELL LYMPHOMA REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA GERMINAL CENTER B-CELL TYPE REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED REFRACTORY HIGH GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 OR BCL6 REARRANGEMENTS REFRACTORY HIGH GRADE B-CELL LYMPHOMA WITH MYC, BCL2, AND BCL6 REARRANGEMENTS REFRACTORY HIGH GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED REFRACTORY T-CELL/HISTIOCYTE-RICH LARGE B-CELL LYMPHOMA

Contacts and locations

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Locations

Aultman Health Foundation
RECRUITING

Canton, Ohio, 44710, United States

Contact Email: •••••@•••••
Banner University Medical Center - Tucson
SUSPENDED

Tucson, Arizona, 85719, United States
Benefis Sletten Cancer Institute
SUSPENDED

Great Falls, Montana, 59405, United States
Billings Clinic Cancer Center
SUSPENDED

Billings, Montana, 59101, United States
Bozeman Health Deaconess Hospital
SUSPENDED

Bozeman, Montana, 59715, United States
Carle BroMenn Medical Center
SUSPENDED

Normal, Illinois, 61761, United States
Carle Cancer Center
SUSPENDED

Urbana, Illinois, 61801, United States
Carle Cancer Institute Normal
SUSPENDED

Normal, Illinois, 61761, United States
Carle Physician Group-Effingham
SUSPENDED

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston
SUSPENDED

Mattoon, Illinois, 61938, United States
Carle at The Riverfront
SUSPENDED

Danville, Illinois, 61832, United States
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States

Contact Email: •••••@•••••
Community Hospital of Anaconda
SUSPENDED

Anaconda, Montana, 59711, United States
Community Medical Center
SUSPENDED

Missoula, Montana, 59804, United States
Drexel Town Square Health Center
SUSPENDED

Oak Creek, Wisconsin, 53154, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Duluth Clinic Ashland
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact Email: •••••@•••••
Essentia Health - Deer River Clinic
RECRUITING

Deer River, Minnesota, 56636, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center-South University Clinic
RECRUITING

Fargo, North Dakota, 58103, United States

Contact Email: •••••@•••••
Essentia Health Hibbing Clinic
RECRUITING

Hibbing, Minnesota, 55746, United States
Essentia Health Saint Joseph's Medical Center
RECRUITING

Brainerd, Minnesota, 56401, United States

Contact Email: •••••@•••••
Essentia Health Saint Mary's Hospital - Superior
RECRUITING

Superior, Wisconsin, 54880, United States
Essentia Health Sandstone
RECRUITING

Sandstone, Minnesota, 55072, United States

Contact Email: •••••@•••••
Essentia Health Virginia Clinic
RECRUITING

Virginia, Minnesota, 55792, United States

Contact Email: •••••@•••••
Essentia Health-Spooner Clinic
RECRUITING

Spooner, Wisconsin, 54801, United States

Contact Email: •••••@•••••
Froedtert Menomonee Falls Hospital
SUSPENDED

Menomonee Falls, Wisconsin, 53051, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
SUSPENDED

West Bend, Wisconsin, 53095, United States
Froedtert and MCW Moorland Reserve Health Center
SUSPENDED

New Berlin, Wisconsin, 53151, United States
Gundersen Lutheran Medical Center
RECRUITING

La Crosse, Wisconsin, 54601, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Post Falls
SUSPENDED

Post Falls, Idaho, 83854, United States
Kootenai Clinic Cancer Services - Sandpoint
SUSPENDED

Sandpoint, Idaho, 83864, United States
Kootenai Health - Coeur d'Alene
SUSPENDED

Coeur d'Alene, Idaho, 83814, United States
Mary Greeley Medical Center
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Ames
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Boone
SUSPENDED

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson
SUSPENDED

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown
RECRUITING

Marshalltown, Iowa, 50158, United States
McFarland Clinic - Trinity Cancer Center
RECRUITING

Fort Dodge, Iowa, 50501, United States
Medical College of Wisconsin
SUSPENDED

Milwaukee, Wisconsin, 53226, United States
Memorial Hospital East
RECRUITING

Shiloh, Illinois, 62269, United States
Mercy Hospital
SUSPENDED

Cedar Rapids, Iowa, 52403, United States
Mercyhealth Hospital and Cancer Center - Janesville
RECRUITING

Janesville, Wisconsin, 53548, United States

Contact Email: •••••@•••••
National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States
Nebraska Medicine-Bellevue
RECRUITING

Bellevue, Nebraska, 68123, United States
Nebraska Medicine-Village Pointe
RECRUITING

Omaha, Nebraska, 68118, United States
Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States
Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern Medicine Glenview Outpatient Center
RECRUITING

Glenview, Illinois, 60026, United States
Northwestern Medicine Grayslake Outpatient Center
RECRUITING

Grayslake, Illinois, 60030, United States
Northwestern Medicine Lake Forest Hospital
RECRUITING

Lake Forest, Illinois, 60045, United States

Contact Email: •••••@•••••
Northwestern Medicine Oak Brook
RECRUITING

Oak Brook, Illinois, 60523, United States
Northwestern Medicine Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Ochsner Medical Center Jefferson
RECRUITING

New Orleans, Louisiana, 70121, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Oncology Associates at Mercy Medical Center
SUSPENDED

Cedar Rapids, Iowa, 52403, United States
ProHealth D N Greenwald Center
SUSPENDED

Mukwonago, Wisconsin, 53149, United States
ProHealth Oconomowoc Memorial Hospital
SUSPENDED

Oconomowoc, Wisconsin, 53066, United States
Providence Newberg Medical Center
RECRUITING

Newberg, Oregon, 97132, United States

Contact Email: •••••@•••••
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact Email: •••••@•••••
Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

Contact Email: •••••@•••••
Providence Willamette Falls Medical Center
RECRUITING

Oregon City, Oregon, 97045, United States

Contact Email: •••••@•••••
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

Contact Email: •••••@•••••
Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

Contact Email: •••••@•••••
Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital Care Center - Guilford
RECRUITING

Guilford, Connecticut, 06437, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital-Derby Care Center
RECRUITING

Derby, Connecticut, 06418, United States

Contact Email: •••••@•••••
Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Email: •••••@•••••
UW Cancer Center at ProHealth Care
SUSPENDED

Waukesha, Wisconsin, 53188, United States
University of Arizona Cancer Center-North Campus
SUSPENDED

Tucson, Arizona, 85719, United States
University of Cincinnati Cancer Center-UC Medical Center
SUSPENDED

Cincinnati, Ohio, 45219, United States
University of Cincinnati Cancer Center-West Chester
SUSPENDED

West Chester, Ohio, 45069, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States
University of Vermont and State Agricultural College
RECRUITING

Burlington, Vermont, 05405, United States
University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact Email: •••••@•••••
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITING

Madison, Wisconsin, 53718, United States

Contact Email: •••••@•••••
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States

Contact Email: •••••@•••••
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

Contact Email: •••••@•••••

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