Immunotherapy boosts standard chemo in rare abdominal cancer trial

NCT ID NCT05001880

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 10 times

Summary

This phase 2 trial is testing whether adding the immunotherapy drug atezolizumab to standard chemotherapy (carboplatin, pemetrexed, and bevacizumab) works better than chemotherapy alone for peritoneal mesothelioma, a rare cancer of the abdominal lining. About 66 people will take part. The goal is to see if the combination shrinks tumors more effectively.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Atezolizumab (immunotherapy) added to standard chemotherapy (carboplatin, pemetrexed, bevacizumab)
What this could lead to: If it works, this could point toward a more effective treatment for peritoneal mesothelioma, potentially improving response rates and survival.
What could go wrong: This is a phase 2 trial with only 66 participants, so results are preliminary. Adding immunotherapy may increase side effects without clear benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

malignant peritoneal mesothelioma peritoneal mesothelioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERITONEAL MALIGNANT MESOTHELIOMA

Contacts and locations

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Locations

Abbott-Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States
Alliance for Clinical Trials in Oncology
RECRUITING

Chicago, Illinois, 60606, United States
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
Fairview Southdale Hospital
RECRUITING

Edina, Minnesota, 55435, United States
Marshfield Medical Center - Minocqua
RECRUITING

Minocqua, Wisconsin, 54548, United States

Contact Email: •••••@•••••
Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

Contact Email: •••••@•••••
Marshfield Medical Center-EC Cancer Center
RECRUITING

Eau Claire, Wisconsin, 54701, United States

Contact Email: •••••@•••••
Marshfield Medical Center-Marshfield
RECRUITING

Marshfield, Wisconsin, 54449, United States

Contact Email: •••••@•••••
Marshfield Medical Center-Rice Lake
RECRUITING

Rice Lake, Wisconsin, 54868, United States

Contact Email: •••••@•••••
Marshfield Medical Center-River Region at Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54482, United States

Contact Email: •••••@•••••
Mayo Clinic Hospital in Arizona
SUSPENDED

Phoenix, Arizona, 85054, United States
Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital
RECRUITING

Willmar, Minnesota, 56201, United States
Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

Contact Email: •••••@•••••
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Email: •••••@•••••
Sanford Cancer Center Worthington
RECRUITING

Worthington, Minnesota, 56187, United States
Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

Contact Email: •••••@•••••
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
The Carle Foundation Hospital
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
ThedaCare Regional Cancer Center
RECRUITING

Appleton, Wisconsin, 54911, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UT MD Anderson - League City
RECRUITING

League City, Texas, 77573, United States
UT MD Anderson - Sugar Land
RECRUITING

Sugar Land, Texas, 77478, United States
UT MD Anderson - The Woodlands
RECRUITING

Conroe, Texas, 77384, United States
UT MD Anderson - West Houston
RECRUITING

Houston, Texas, 77079, United States
UT MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States
Unity Hospital
ACTIVE_NOT_RECRUITING

Fridley, Minnesota, 55432, United States
University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
University of Kentucky/Markey Cancer Center
ACTIVE_NOT_RECRUITING

Lexington, Kentucky, 40536, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

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