National Cancer Institute (nci)

This early-stage study tested a new type of personalized cancer treatment. Researchers collected a patient's own immune cells (T cells), modified them in a lab to better recognize and attack cancer cells, and then infused them back into the patient. The goal was to see if this ap…

This early-stage study tested a new drug, BMS-986253, for adults with myelodysplastic syndromes (MDS), a serious bone marrow disorder. The goal was to see if the drug was safe and could help control the disease, either alone or combined with standard medications. The trial was te…

This early-stage study tested a new oral drug called navtemadlin (AMG 232) for glioblastoma, a fast-growing brain cancer. The trial had two parts: first, to see if the drug could reach brain tumor tissue in patients whose cancer had returned; second, to find a safe dose to combin…

This early-phase study tested a combination of two antibody drugs, magrolimab and mogamulizumab, for patients with advanced T-cell skin lymphomas that had returned or stopped responding to prior treatments. The main goals were to find a safe dose and see if adding magrolimab help…

This study tested whether a drug called SGI-110 could shrink or slow the growth of certain rare cancers, including specific types of stomach, adrenal, and kidney tumors. It was for patients aged 12 and older whose cancers had not responded to standard treatments. Participants rec…

This early-phase study tested whether combining a prescription fish oil (icosapent ethyl) with the cancer drug dasatinib could help control a rare and aggressive form of breast cancer that had spread. The goal was to find a safe dose and see if the combination could shrink tumors…

This study tested whether combining three existing drugs—nivolumab (an immunotherapy), tadalafil (a blood pressure/erectile dysfunction drug), and oral vancomycin (an antibiotic)—could shrink advanced liver cancers. It was for adults whose liver cancer (either starting in the liv…

This was an early-stage study testing a new gene therapy for advanced cancer that had spread. Doctors took a patient's own white blood cells, genetically modified them in a lab to recognize a specific protein found on cancer cells, and then infused them back into the patient. The…

This study aimed to see if adding a new drug called copanlisib to standard treatments could better control advanced HER2-positive breast cancer in people with specific genetic changes. It was designed to first find a safe dose and then test if the three-drug combination could kee…

This early-stage study tested a new treatment for women with advanced ovarian, fallopian tube, or primary peritoneal cancer that has returned or stopped responding to standard therapies. Researchers collected a patient's own immune cells (monocytes), activated them with two drugs…

This early-phase trial tested a new combination of two oral drugs, eltanexor and Inqovi, for adults with high-risk myelodysplastic syndromes (MDS), a serious bone marrow disorder that can lead to leukemia. The study aimed to find a safe, effective dose and see if the combo could …

This study tested whether adding an immunotherapy drug called nivolumab to standard chemotherapy could help people with advanced nasopharyngeal cancer that has come back or spread. It aimed to see if the combination helped patients live longer or better control the cancer compare…

This study tested if adding a targeted drug called binimetinib to standard hormone therapy (fulvestrant) could better control advanced breast cancer that has a specific genetic change (NF1). It aimed to see if the combination could shrink tumors more effectively or keep the cance…

This study tested a combination of two drugs, VB-111 and nivolumab, for people with advanced colorectal cancer that had spread to the liver and had stopped responding to standard chemotherapy. The main goals were to check if the treatment was safe and to see if it could cause tum…

This early-stage study tested the safety and best dose of two immunotherapy drugs, nivolumab and ipilimumab, for people living with HIV who also have advanced cancers like Hodgkin lymphoma, Kaposi sarcoma, or lung cancer. The goal was to see if these drugs, which help the immune …

This early-stage study tested a combination of two chemotherapy drugs, pevonedistat and belinostat, in adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that had returned or stopped responding to other treatments. The main goal was to find the highest dos…

This early-stage study tested a new drug, KRT-232, added to a standard three-drug combination for multiple myeloma that has come back or stopped responding to treatment. The main goals were to find the safest dose and see how well the body handles the four-drug combination. It in…

This early-stage study tested a combination of two drugs, AZD1775 and belinostat, for patients with advanced blood cancers like acute myeloid leukemia (AML) that have returned or not responded to prior treatments. The main goal was to find the safest and most effective dose of th…

This study tested if adding an experimental drug called Zotiraciclib to a standard chemotherapy (temozolomide) could better control aggressive brain tumors that have returned after initial treatment. The trial had two parts: first to find a safe dose, then to compare how long the…

This study aimed to test if a drug called sacituzumab govitecan could help control recurrent ovarian, endometrial, or cervical cancers that had returned after at least two prior treatments. The drug was given by IV infusion to see if it could shrink tumors. The trial was terminat…

This study tested an experimental radioactive drug designed to target and treat cancer that has spread to the bones from prostate cancer. The main goal was to see if the treatment could provide lasting relief from the severe bone pain caused by these metastases. The trial was ter…

This study aimed to collect fluid samples from the abdomen or chest and blood from adults with solid tumors. The goal was to analyze these samples to better understand cancer biology. Researchers hoped this knowledge would help develop improved cancer treatments in the future. No…