New hope for rare uterine cancer? trial tests avastin with chemo

NCT ID NCT01012297

Terminated Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tested whether adding bevacizumab (Avastin) to standard chemotherapy (docetaxel and gemcitabine) helps people with advanced or recurrent uterine leiomyosarcoma. The study enrolled 107 participants but was terminated early. Researchers measured how long patients lived without the cancer growing (progression-free survival) and overall survival. The goal was to see if the drug combo works better than chemo alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Bevacizumab (Avastin) added to chemotherapy (docetaxel and gemcitabine)

What this could lead to

If it works, adding bevacizumab could help slow tumor growth or improve survival for people with advanced uterine leiomyosarcoma.

What could go wrong

The trial was terminated early with only 107 participants, so results are limited. Bevacizumab may not improve outcomes and can cause side effects like bleeding or high blood pressure.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

leiomyosarcoma of the corpus uteri uterine corpus sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT UTERINE CORPUS SARCOMA STAGE IIIA UTERINE SARCOMA STAGE IIIB UTERINE SARCOMA STAGE IIIC UTERINE SARCOMA STAGE IVA UTERINE SARCOMA STAGE IVB UTERINE SARCOMA UTERINE CORPUS LEIOMYOSARCOMA

Contacts and locations

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Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Abington Memorial Hospital

Abington, Pennsylvania, 19001, United States
Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States
Baptist Health Lexington

Lexington, Kentucky, 40503, United States
Baylor All Saints Medical Center at Fort Worth

Fort Worth, Texas, 76104, United States
Beebe Medical Center

Lewes, Delaware, 19958, United States
Borgess Medical Center

Kalamazoo, Michigan, 49001, United States
Boulder Community Hospital

Boulder, Colorado, 80301, United States
Bronson Battle Creek

Battle Creek, Michigan, 49017, United States
Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States
Cadence Cancer Center in Warrenville

Warrenville, Illinois, 60555, United States
Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States
Cancer Research for the Ozarks NCORP

Springfield, Missouri, 65804, United States
Carolinas HealthCare System NorthEast

Concord, North Carolina, 28025, United States
Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Center of Hope at Renown Medical Center

Reno, Nevada, 89502, United States
Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States
Clements University Hospital

Dallas, Texas, 75390, United States
Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Colorado Cancer Research Program CCOP

Denver, Colorado, 80224-2522, United States
Community Howard Regional Health

Kokomo, Indiana, 46904, United States
Cooper Hospital University Medical Center

Camden, New Jersey, 08103, United States
CoxHealth South Hospital

Springfield, Missouri, 65807, United States
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Elkhart Clinic

Elkhart, Indiana, 46514-2098, United States
Elkhart General Hospital

Elkhart, Indiana, 46515, United States
Exempla Saint Joseph Hospital

Denver, Colorado, 80218, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview-Southdale Hospital

Edina, Minnesota, 55435, United States
Florida Hospital Orlando

Orlando, Florida, 32803, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Franciscan Saint Francis Health-Indianapolis

Indianapolis, Indiana, 46237, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Medical Center-Cancer Center Hazleton

Hazleton, Pennsylvania, 18201, United States
Geisinger Medical Group

State College, Pennsylvania, 16801, United States
Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States
Georgia Regents University Medical Center

Augusta, Georgia, 30912, United States
Grand Rapids Clinical Oncology Program

Grand Rapids, Michigan, 49503, United States
Greater Baltimore Medical Center

Baltimore, Maryland, 21204, United States
Gynecologic Oncology of Indiana

Indianapolis, Indiana, 46237, United States
Hartford Hospital

Hartford, Connecticut, 06102, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Hutchinson Area Health Care

Hutchinson, Minnesota, 55350, United States
IU Health La Porte Hospital

La Porte, Indiana, 46350, United States
Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States
Iowa Lutheran Hospital

Des Moines, Iowa, 50316, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Iowa Oncology Research Association CCOP

Des Moines, Iowa, 50309, United States
John B Amos Cancer Center

Columbus, Georgia, 31904, United States
John Muir Medical Center-Concord Campus

Concord, California, 94520, United States
John Muir Medical Center-Walnut Creek

Walnut Creek, California, 94598, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, 90027, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805, United States
Lake University Ireland Cancer Center

Mentor, Ohio, 44060, United States
Lakeland Hospital

Saint Joseph, Michigan, 49085, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States
Littleton Adventist Hospital

Littleton, Colorado, 80122, United States
Longmont United Hospital

Longmont, Colorado, 80501, United States
Los Angeles County-USC Medical Center

Los Angeles, California, 90033, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States
McKee Medical Center

Loveland, Colorado, 80539, United States
MedStar Franklin Square Medical Center/Weinberg Cancer Institute

Baltimore, Maryland, 21237, United States
Medical Oncology and Hematology Associates-Des Moines

Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates-Laurel

Des Moines, Iowa, 50314, United States
Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa, 50325, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Hospital of South Bend

South Bend, Indiana, 46601, United States
Memorial Medical Center

Springfield, Illinois, 62781, United States
Memorial Medical Center - Las Cruces

Las Cruces, New Mexico, 88011, United States
Memorial Sloan-Kettering Cancer Center

New York, New York, 10065, United States
Memorial University Medical Center

Savannah, Georgia, 31404, United States
Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States
Mercy Health Mercy Campus

Muskegon, Michigan, 49444, United States
Mercy Health Saint Mary's

Grand Rapids, Michigan, 49503, United States
Mercy Hospital

Miami, Florida, 33133, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266, United States
Methodist West Hospital

West Des Moines, Iowa, 50266-7700, United States
Metro Health Hospital

Wyoming, Michigan, 49519, United States
Metro-Minnesota NCI Community Oncology Research Program

Saint Louis Park, Minnesota, 55416, United States
MetroHealth Medical Center

Cleveland, Ohio, 44109, United States
Michiana Hematology Oncology PC-Elkhart

Elkhart, Indiana, 46514, United States
Michiana Hematology Oncology PC-Mishawaka

Mishawaka, Indiana, 46545, United States
Michiana Hematology Oncology PC-Niles

Niles, Michigan, 49120, United States
Michiana Hematology Oncology PC-Plymouth

Plymouth, Indiana, 46563, United States
Michiana Hematology Oncology PC-South Bend

South Bend, Indiana, 46601, United States
Michiana Hematology Oncology PC-Westville

Westville, Indiana, 46391, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology and Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Morristown Medical Center

Morristown, New Jersey, 07960, United States
Mount Sinai Medical Center

New York, New York, 10029, United States
Munson Medical Center

Traverse City, Michigan, 49684, United States
Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States
New Ulm Medical Center

New Ulm, Minnesota, 56073, United States
North Colorado Medical Center

Greeley, Colorado, 80631, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
North Suburban Medical Center

Thornton, Colorado, 80229, United States
Northern Indiana Cancer Research Consortium CCOP

South Bend, Indiana, 46628, United States
Northwestern University

Chicago, Illinois, 60611, United States
Norton Hospital Pavilion and Medical Campus

Louisville, Kentucky, 40202, United States
Novant Health Presbyterian Medical Center

Charlotte, North Carolina, 28204, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Olive View-University of California Los Angeles Medical Center

Sylmar, California, 91342, United States
Overlook Hospital

Summit, New Jersey, 07902, United States
Palo Alto Medical Foundation-Gynecologic Oncology

Mountain View, California, 94040, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Parker Adventist Hospital

Parker, Colorado, 80138, United States
Parkland Memorial Hospital

Dallas, Texas, 75235, United States
Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States
Pennsylvania Hospital

Philadelphia, Pennsylvania, 19107, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Porter Adventist Hospital

Denver, Colorado, 80210, United States
Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, 80218, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States
Reading Hospital

West Reading, Pennsylvania, 19611, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Rocky Mountain Gynecologic Oncology PC

Englewood, Colorado, 80110, United States
Rose Medical Center

Denver, Colorado, 80220, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
SCL Health Lutheran Medical Center

Wheat Ridge, Colorado, 80033, United States
Saint Anthony Hospital

Lakewood, Colorado, 80228, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Joseph Regional Medical Center-Mishawaka

Mishawaka, Indiana, 46545, United States
Saint Joseph's Hospital and Medical Center

Phoenix, Arizona, 85013, United States
Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States
Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, 81502, United States
Saint Vincent Oncology Center

Indianapolis, Indiana, 46260, United States
Sanford Cancer Center-Oncology Clinic

Sioux Falls, South Dakota, 57104, United States
Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States
Sky Ridge Medical Center

Lone Tree, Colorado, 80124, United States
South Bend Clinic

South Bend, Indiana, 46617, United States
Southwest Gynecologic Oncology Associates Inc

Albuquerque, New Mexico, 87106, United States
Spectrum Health Big Rapids Hospital

Big Rapids, Michigan, 49307, United States
Spectrum Health Reed City Hospital

Reed City, Michigan, 49677, United States
Spectrum Health at Butterworth Campus

Grand Rapids, Michigan, 49503, United States
State University of New York Downstate Medical Center

Brooklyn, New York, 11203, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Sudarshan K Sharma MD Limted-Gynecologic Oncology

Hinsdale, Illinois, 60521, United States
Summa Akron City Hospital/Cooper Cancer Center

Akron, Ohio, 44304, United States
Swedish Medical Center

Englewood, Colorado, 80113, United States
The Hospital of Central Connecticut

New Britain, Connecticut, 06050, United States
The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202, United States
The Medical Center of Aurora

Aurora, Colorado, 80012, United States
Tulsa Cancer Institute

Tulsa, Oklahoma, 74146, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, 90095, United States
UCSF Medical Center-Mount Zion

San Francisco, California, 94115, United States
UF Cancer Center at Orlando Health

Orlando, Florida, 32806, United States
UMDNJ - Robert Wood Johnson University Hospital

New Brunswick, New Jersey, 08903, United States
UPMC-Magee Womens Hospital

Pittsburgh, Pennsylvania, 15213, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
Union Hospital of Cecil County

Elkton, Maryland, 21921, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University of California San Diego

San Diego, California, 92103, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Cincinnati

Cincinnati, Ohio, 45267, United States
University of Colorado Cancer Center - Anschutz Cancer Pavilion

Aurora, Colorado, 80045, United States
University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of New Mexico

Albuquerque, New Mexico, 87102, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Vermont Medical Center

Burlington, Vermont, 05401, United States
University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792, United States
Virtua Memorial

Mount Holly, New Jersey, 08060, United States
Virtua West Jersey Hospital Voorhees

Voorhees Township, New Jersey, 08043, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Walter Reed National Military Medical Center

Bethesda, Maryland, 20889-5600, United States
Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
West Penn Hospital

Pittsburgh, Pennsylvania, 15224, United States
Women and Infants Hospital

Providence, Rhode Island, 02905, United States
Women's Cancer Care Associates LLC

Albany, New York, 12208, United States
Women's Cancer Center of Nevada

Las Vegas, Nevada, 89169, United States
Zale Lipshy University Hospital

Dallas, Texas, 75235, United States