National Cancer Institute (nci)

This study is testing whether combining the drug luspatercept with one of two other medications works better than luspatercept alone for treating anemia in people with lower-risk myelodysplastic syndrome (MDS). The main goal is to see if these combinations help patients make more…

This is a first-in-human study to find a safe dose of a new radioactive drug, Sn-117m-DTPA, for patients whose prostate, breast, or non-small cell lung cancer has spread to their bones. The drug is designed to deliver radiation directly to bone tumors while trying to spare the he…

This study is for adults with high-risk multiple myeloma, a blood cancer, that has either returned after initial treatment or stopped responding to it. It compares a new two-drug combination (daratumumab + teclistamab) against two standard three-drug combinations. The main goal i…

This study is testing if adding an inhaled drug called azacytidine to standard pre-surgery treatment can better shrink early-stage lung cancer tumors. The goal is to find the safest dose of the inhaled drug and see if it helps eliminate more cancer cells before surgery. About 60 …

This study is for adults aged 60 or older with newly diagnosed acute myeloid leukemia (AML) who are less fit for intensive chemotherapy. It compares two treatment schedules combining the same three oral medications. The goal is to see if taking one of the drugs for 14 days per cy…

This study is testing if adding a drug called venetoclax to a stem cell transplant helps adults with acute myeloid leukemia (AML) stay in remission longer. Participants will receive either venetoclax or a placebo (inactive pill) before and after their transplant. The main goal is…

This study aims to find out if adding a newer drug called venetoclax to standard chemotherapy works as well as or better than adding an older targeted drug called gemtuzumab ozogamicin for treating a specific type of acute myeloid leukemia (AML). It will enroll 162 younger adults…

This study is testing whether combining two newer cancer drugs can help control aggressive small cell lung cancer and similar neuroendocrine cancers that have returned or stopped responding to standard treatments. The trial will enroll about 120 adults whose cancer has progressed…

This study is testing whether giving an immunotherapy drug called atezolizumab after surgery can prevent early-stage non-small cell lung cancer from returning. It will compare patients who receive the drug for one year against those who receive standard follow-up care with observ…

This study is testing if adding a new drug called olutasidenib to standard treatments helps patients with certain blood cancers. It is for adults newly diagnosed with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) who have a specific genetic change called an IDH1 …

This study is for adults with a type of blood cancer called acute myeloid leukemia (AML) who have a small amount of leftover cancer after initial treatment. The goal is to test if adding newer drugs to a standard chemotherapy is better at wiping out these hidden cancer cells befo…

This study is for adults with multiple myeloma (a blood cancer) that has come back after one or two prior treatments. It aims to see if a new two-drug combination (teclistamab and pomalidomide) is safer and works better than a standard three-drug combination. Researchers will che…

This study is testing the safety and effectiveness of a new two-drug combination for people with advanced colorectal cancer that has stopped responding to standard treatments. The trial combines an experimental drug (pidnarulex) that aims to stop cancer cell growth with an immuno…

This early-stage trial is testing whether a new drug called camonsertib, combined with a precise form of radiation therapy, can help control head and neck cancers that have returned or cannot be surgically removed. The main goals are to find the safest dose of the drug-radiation …

This study is testing if adding a weekly weight-loss injection (tirzepatide) to a hormone-releasing IUD can better treat early-stage uterine cancer or a pre-cancerous condition in women who are overweight or obese. The goal is to see if this combination can eliminate cancer cells…

This early-stage study aims to find a safe dose and understand the side effects of an oral drug combination called ASTX727, given with a white blood cell booster (filgrastim), in children with high-risk acute myeloid leukemia (AML). The treatment is given as 'maintenance therapy'…

This study is testing whether adding a new drug called iberdomide to a standard combination of chemotherapy and immunotherapy is safe and more effective for children and young adults with neuroblastoma that has returned, is not responding, or is getting worse after prior treatmen…

This large, Phase 3 trial is testing if a gentler treatment plan works as well as a stronger one for a specific type of breast cancer. It will enroll nearly 2,000 postmenopausal women and men with high-stage, hormone-sensitive, HER2-negative breast cancer that has a low genetic r…

This early-stage study aims to find a safe and effective dose of a new drug called glofitamab when given alongside standard chemotherapy for people with previously untreated mantle cell lymphoma, a type of blood cancer. The main goal is to check for side effects and determine the…

This is an early-stage trial to see if combining two existing drugs, azacitidine and abatacept, is safe and can shrink tumors in people with T-cell lymphoma that has come back or not responded to prior treatment. The study will involve about 20 adults to find the right dose and s…

This early-stage study is testing a new two-drug combination for glioblastoma, an aggressive brain cancer that has returned after initial treatment. The first drug is a radioactive antibody designed to find and deliver radiation directly to cancer cells. The second drug is an imm…

This early-stage study is testing a new drug called teclistamab in adults whose plasmablastic lymphoma has come back or hasn't responded to previous treatments. The main goals are to find the safest dose and see what side effects occur, while also checking if the drug helps contr…

This study is testing whether an oral medication called TPST-1495 can reduce the number of polyps in the small intestine and rectum of people with familial adenomatous polyposis (FAP), an inherited condition that causes many polyps and increases colon cancer risk. The trial will …

This study is testing if adding the drug itraconazole to the standard heat treatment (ablation) can better prevent esophageal cancer in people with high-risk Barrett's esophagus. It will involve 64 participants who will receive either itraconazole or a placebo pill alongside thei…

This study is for children and adults (ages 3-65) with a type of blood cancer called B-cell acute lymphoblastic leukemia (ALL). The goal is to see if giving a second, different CAR T-cell treatment (targeting CD22) to people who are already in remission after their first CAR T-ce…

This study is testing if adding a new immunotherapy drug called cemiplimab to standard chemotherapy before surgery works better than chemotherapy alone for advanced sinonasal squamous cell carcinoma, a rare cancer in the nasal cavity and sinuses. The goal is to see if the combina…

This study is testing a vaccine designed to prevent lung cancer in people at high risk, primarily former and current heavy smokers. The vaccine works by training the body's immune system to recognize and attack cells that could become cancerous. Researchers will enroll 80 partici…

This is a survey to find people who might qualify for one of several ongoing cancer genetics research studies. The goal is to better understand why some people and families get certain cancers. Participants fill out a 15-20 minute online questionnaire about their personal and fam…

This study aims to understand the quality of care for adolescents and young adults (ages 12-39) living with advanced or recurrent cancer. Researchers will survey and interview patients, caregivers, and clinicians to measure unmet needs in areas like emotional support, communicati…