Can a vaccine plus a Blood-Vessel blocker stop airway growths from coming back?
NCT ID NCT07756840
First seen Aug 11, 2026 · Last updated Aug 14, 2026 · Updated 3 times
Summary
This phase II trial tests whether combining bevacizumab, a drug that limits blood vessel growth, with PRGN-2012, a vaccine-based therapy, can help adults with recurrent respiratory papillomatosis (RRP) avoid needing more surgeries. RRP causes wart-like growths in the airway that can affect breathing and voice. Participants receive both treatments over about six months and are followed for a year to see if the growths stay away without further intervention.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A combination of two treatments: bevacizumab (a drug that blocks blood vessel growth) and PRGN-2012 (a vaccine-based therapy that targets HPV).
- What this could lead to
- If successful, this combination could reduce or eliminate the need for repeated surgeries in people with recurrent respiratory papillomatosis, potentially improving breathing and voice function.
- What could go wrong
- This is a phase II trial with a modest number of participants, so results may not generalize. The combination may cause side effects, and the vaccine component may not work in all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
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