National Cancer Institute (nci)

This early-phase trial tests a combination of two drugs—erdafitinib and enfortumab vedotin—for people with advanced bladder cancer that has spread and has specific changes in the FGFR2/3 genes. The study includes about 24 adults whose cancer worsened after standard chemotherapy. …

This study tests whether adding the immunotherapy drug atezolizumab to standard chemoradiation helps people with muscle-invasive bladder cancer live longer without their cancer returning. About 475 adults with localized disease that hasn't spread are taking part. The goal is to s…

This study looked at whether adding the drug bevacizumab to standard chemotherapy after surgery helps people with ovarian, peritoneal, or fallopian tube cancer that has come back live longer. Over 1,000 participants were randomly assigned to receive chemo alone or chemo plus beva…

This study tests whether adding the immunotherapy drug nivolumab after standard chemo-radiation helps people with HPV-positive throat cancer live longer and stay cancer-free longer. About 636 adults with intermediate-risk, locally advanced disease will either receive nivolumab or…

This study tests a new drug called pevonedistat, given alone or with standard chemotherapy (paclitaxel and carboplatin), in people with advanced bile duct cancer that has spread or cannot be removed. The goal is to see if the combination can shrink tumors. About 40 adults who hav…

This study is testing whether adding a new targeted drug to an existing immunotherapy works better for treating a specific type of advanced lung cancer called pleural mesothelioma. The new drug acts like a guided missile, attaching to cancer cells and delivering a chemotherapy pa…

This study is testing whether the drug crizotinib can shrink or stop the growth of advanced cancers that have a specific genetic change called a ROS1 translocation. The trial includes patients with various advanced solid tumors, lymphoma, or multiple myeloma that have not respond…

This study is testing if adding an experimental drug called berzosertib to a standard chemotherapy (carboplatin) works better for treating advanced prostate cancer that has spread and stopped responding to hormone therapy. It compares this new combination to the standard treatmen…

This early-stage trial is testing a new combination treatment for advanced neuroendocrine tumors that have spread in the digestive system. Researchers are combining an oral pill (peposertib) with a targeted radiation therapy (Lutetium-177 dotatate) to see if they work better toge…

This study tested whether giving the immunotherapy drug nivolumab after lung cancer surgery and chemotherapy helps prevent the cancer from returning. It involved 903 people with stage IB-IIIA non-small cell lung cancer who had their tumors surgically removed. Half received nivolu…

This early-stage trial is testing the safety and early effectiveness of a drug called pembrolizumab in children and young adults whose aggressive brain tumors have come back or stopped responding to standard treatments. The drug is a type of immunotherapy designed to help the bod…

This long-term study aims to understand why farmers and their families may have higher risks for certain cancers, like prostate cancer and lymphoma. Researchers are following about 90,000 pesticide applicators and their spouses in Iowa and North Carolina, collecting information o…