Lifestyle changes may boost gut health in melanoma fight

NCT ID NCT04866810

Terminated Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a high-fiber, plant-based diet and regular exercise can change the gut microbiome in people with melanoma who are receiving immunotherapy. Researchers want to see if these lifestyle changes are feasible and if they might affect how well the treatment works. The study involves 24 adults and is conducted remotely via phone or video calls.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: High-fiber, plant-based diet and exercise prescription
What this could lead to: If successful, this could show that lifestyle changes can influence the gut microbiome and possibly improve outcomes for melanoma patients on immunotherapy.
What could go wrong: This is a small, early feasibility study (24 participants) that is currently suspended. It is designed to test whether the study procedures work, not to prove any health benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MELANOMA

Contacts and locations

Locations

Loma Linda University

Loma Linda, California, 92350, United States
National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

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