New hope for tough leukemia: drug combo targets hidden cancer cells

NCT ID NCT05146739

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests a new drug called uproleselan combined with two standard chemotherapy drugs for children and teens with acute myeloid leukemia or related blood cancers that have returned or not responded to treatment. The drug works by blocking a protein that helps cancer cells hide in the bone marrow, making chemotherapy more effective. The main goal is to find the safest dose and understand how the drug works in the body.

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Conditions

The condition(s) this trial relates to.

acute biphenotypic leukemia acute myeloid leukemia mixed phenotype acute leukemia myelodysplastic syndrome myelodysplastic syndrome with excess blasts Myelodysplastic Syndromes myeloid leukemia associated with down syndrome therapy related acute myeloid leukemia and myelodysplastic syndrome therapy-related myeloid neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA POST CYTOTOXIC THERAPY MYELODYSPLASTIC SYNDROME POST CYTOTOXIC THERAPY MYELOID LEUKEMIA ASSOCIATED WITH DOWN SYNDROME RECURRENT ACUTE MYELOID LEUKEMIA RECURRENT MIXED PHENOTYPE ACUTE LEUKEMIA RECURRENT MYELODYSPLASTIC SYNDROME REFRACTORY ACUTE MYELOID LEUKEMIA REFRACTORY MIXED PHENOTYPE ACUTE LEUKEMIA REFRACTORY MYELODYSPLASTIC SYNDROME

Contacts and locations

Locations

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States
C S Mott Children's Hospital

Ann Arbor, Michigan, 48109, United States
Children's Healthcare of Atlanta - Arthur M Blank Hospital

Atlanta, Georgia, 30329, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital of Alabama

Birmingham, Alabama, 35233, United States
Children's Hospital of Orange County

Orange, California, 92868, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, 15224, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Lurie Children's Hospital-Chicago

Chicago, Illinois, 60611, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Riley Hospital for Children

Indianapolis, Indiana, 46202, United States
Saint Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
UCSF Medical Center-Mission Bay

San Francisco, California, 94158, United States
University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, 55455, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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