Experimental drug combo shows promise for Tough-to-Treat gynecologic cancers

NCT ID NCT02595879

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This early-phase study tested an oral drug called triapine added to standard chemotherapy (cisplatin) and radiation for people with advanced cervical or vaginal cancer. The main goals were to find the safest dose and check how well the body absorbs the drug. Twenty-one participants were enrolled, and researchers monitored side effects and tumor response.

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Conditions

The condition(s) this trial relates to.

cervical adenocarcinoma cervical adenosquamous carcinoma cervical cancer cervical squamous cell carcinoma Uterine Cervical Neoplasms vaginal adenocarcinoma vaginal cancer vaginal carcinoma vaginal squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED CERVICAL ADENOCARCINOMA ADVANCED CERVICAL ADENOSQUAMOUS CARCINOMA ADVANCED CERVICAL SQUAMOUS CELL CARCINOMA ADVANCED VAGINAL ADENOCARCINOMA ADVANCED VAGINAL ADENOSQUAMOUS CARCINOMA ADVANCED VAGINAL SQUAMOUS CELL CARCINOMA STAGE IB2 CERVICAL CANCER AJCC V6 AND V7 STAGE II CERVICAL CANCER AJCC V7 STAGE II VAGINAL CANCER AJCC V6 AND V7 STAGE III VAGINAL CANCER AJCC V6 AND V7 STAGE IIIB CERVICAL CANCER AJCC V6 AND V7 STAGE IVA CERVICAL CANCER AJCC V6 AND V7 STAGE IVA VAGINAL CANCER AJCC V6 AND V7

Contacts and locations

Locations

Keck Medical Center of USC Pasadena

Pasadena, California, 91105, United States
Los Angeles General Medical Center

Los Angeles, California, 90033, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Clinical Research Center

Fairway, Kansas, 66205, United States
University of Kansas Hospital-Indian Creek Campus

Overland Park, Kansas, 66211, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States
VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States

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