New drug combo shows promise for Tough-to-Treat bladder cancer
NCT ID NCT04963153
First seen Nov 01, 2025 · Last updated Apr 26, 2026 · Updated 26 times
Summary
This early-phase trial tests a combination of two drugs—erdafitinib and enfortumab vedotin—for people with advanced bladder cancer that has spread and has specific changes in the FGFR2/3 genes. The study includes about 24 adults whose cancer worsened after standard chemotherapy. The goal is to find the safest and most effective dose and see if the combination can shrink or stabilize the cancer.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112, United States
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Los Angeles General Medical Center
Los Angeles, California, 90033, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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NYP/Weill Cornell Medical Center
New York, New York, 10065, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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UCHealth University of Colorado Hospital
Aurora, Colorado, 80045, United States
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USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390, United States
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University Health Network-Princess Margaret Hospital
Toronto, Ontario, M5G 2M9, Canada
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University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232, United States
Conditions
Explore the condition pages connected to this study.