New combo therapy shows promise for Hard-to-Treat blood cancers

NCT ID NCT02160015

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 19 times

Summary

This early-stage study tested a combination of three drugs (lenalidomide, ibrutinib, and rituximab) in 12 people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that had returned or stopped responding to previous treatments. The main goal was to find the safest dose and check for side effects. The approach aims to boost the immune system and block cancer growth, but it is not a cure—patients may need ongoing treatment.

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Contacts and locations

Locations

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • MedStar Georgetown University Hospital

    Washington D.C., District of Columbia, 20007, United States

Conditions

Explore the condition pages connected to this study.