New drug Z-Endoxifen shows promise in early breast cancer trial

NCT ID NCT01327781

First seen Nov 14, 2025 · Last updated May 13, 2026 · Updated 21 times

Summary

This early-phase trial tested a drug called Z-endoxifen in 62 women with estrogen receptor-positive (ER+) breast cancer that had spread or come back. The main goal was to find the safest dose and understand side effects. Z-endoxifen works by blocking estrogen, which can fuel breast cancer growth.

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Contacts and locations

Locations

  • Mayo Clinic in Arizona

    Scottsdale, Arizona, 85259, United States

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224-9980, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

Conditions

Explore the condition pages connected to this study.