Can a Pre-Transplant HPV shot shield patients from cancer?

NCT ID NCT03036930

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether giving the HPV vaccine (Gardasil 9) to adults before a kidney transplant helps their immune system fight HPV after transplant, when they must take drugs that weaken immunity. About 51 participants will receive the vaccine before surgery, and researchers will measure antibody levels afterward. The goal is to see if pre-transplant vaccination can provide lasting protection against HPV-related cancers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Gardasil 9 (nonavalent HPV vaccine)
What this could lead to: If successful, this could show that giving the HPV vaccine before a kidney transplant helps protect patients from HPV-related cancers even when they take immunosuppressants.
What could go wrong: This is a small, early-phase trial (51 participants) with no comparison group. The vaccine may not produce strong enough immunity after transplant, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

end stage renal failure human papilloma virus infection prevention target human papillomavirus-related squamous cell carcinoma prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HUMAN PAPILLOMAVIRUS INFECTION HUMAN PAPILLOMAVIRUS-RELATED CARCINOMA

Contacts and locations

Locations

Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
Northwestern University

Chicago, Illinois, 60611, United States
UCSF Medical Center-Mount Zion

San Francisco, California, 94115, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States

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