New drug targets genetic weakness in bladder cancer
NCT ID NCT03047213
First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This phase 2 trial tests a drug called sapanisertib in 17 people with advanced bladder cancer that has a specific genetic change (TSC1 or TSC2 mutation). The drug works by blocking a protein that helps cancer cells grow. Researchers want to see if the drug can shrink tumors and how safe it is.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sapanisertib (a drug that blocks a protein called mTOR to slow cancer growth)
- What this could lead to
- If it works, this could point toward a targeted treatment for bladder cancer patients with specific genetic mutations.
- What could go wrong
- This is a very small, early-phase trial with only 17 participants, so results may not apply to everyone. The drug may cause side effects and may not shrink tumors in most patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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Keck Medical Center of USC Pasadena
Pasadena, California, 91105, United States
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Los Angeles General Medical Center
Los Angeles, California, 90033, United States
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Nebraska Medicine-Bellevue
Bellevue, Nebraska, 68123, United States
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Nebraska Medicine-Village Pointe
Omaha, Nebraska, 68118, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, 06510, United States
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UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
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UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
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University of Kansas Clinical Research Center
Fairway, Kansas, 66205, United States
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University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, 48109, United States
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University of Nebraska Medical Center
Omaha, Nebraska, 68198, United States
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Vanderbilt Breast Center at One Hundred Oaks
Nashville, Tennessee, 37204, United States
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Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Yale University
New Haven, Connecticut, 06520, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Targeted drug hunts down cancer cells in advanced bladder cancer trial
- New drug option for Hard-to-Treat cancers with FGFR3 mutations
- New bladder cancer drug aims to fight tumors without harming nerves
- New hope for advanced bladder cancer? bevacizumab combo tested
- New cocktail of drugs takes on Hard-to-Treat bladder cancer
- New imaging tracer could spot hidden cancers