Can a targeted drug boost chemo for hard-to-treat blood cancers?
NCT ID NCT03289910
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tested whether adding veliparib (a targeted drug) to standard chemotherapy (topotecan and carboplatin) helps people with advanced myeloproliferative disorders, acute myeloid leukemia, or chronic myelomonocytic leukemia. The study enrolled 25 adults whose cancer had spread or returned. Researchers measured how many patients achieved a complete or partial response, and tracked side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- veliparib (a PARP inhibitor) combined with topotecan and carboplatin (chemotherapy drugs)
- What this could lead to
- If it works, this could point toward a more effective chemotherapy combination for advanced blood cancers that are hard to treat.
- What could go wrong
- This is a small, early-phase (phase II) trial with only 25 participants. The added drug may not improve outcomes and could increase side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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Los Angeles General Medical Center
Los Angeles, California, 90033, United States
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Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903, United States
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UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
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USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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USC Norris Oncology/Hematology-Newport Beach
Newport Beach, California, 92663, United States
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