New Three-Drug combo aims to shrink Hard-to-Treat cancers
NCT ID NCT04068194
First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 2 times
Summary
This study tests a combination of two drugs (peposertib and avelumab) plus a special type of radiation (hypofractionated) in people with advanced solid tumors or liver/bile duct cancers that have spread. The goal is to find the safest dose and see if the combination can shrink tumors. About 103 participants will be enrolled, and the trial is currently active but not recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Peposertib (M3814) and avelumab (Bavencio) plus hypofractionated radiation therapy
- What this could lead to
- If successful, this combination could offer a new treatment option for people with advanced solid tumors or liver/bile duct cancers that have stopped responding to standard therapies.
- What could go wrong
- This is an early-phase trial (phase I/II) with only 103 participants, so the benefits are uncertain. Combining three treatments may cause significant side effects, and the approach may not work for all cancer types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Bellevue Hospital Center
New York, New York, 10016, United States
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010, United States
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Emory Saint Joseph's Hospital
Atlanta, Georgia, 30342, United States
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Emory University Hospital Midtown
Atlanta, Georgia, 30308, United States
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Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322, United States
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Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112, United States
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Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, 10016, United States
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MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032, United States
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NYP/Weill Cornell Medical Center
New York, New York, 10065, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903, United States
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Sibley Memorial Hospital
Washington D.C., District of Columbia, 20016, United States
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Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, 06510, United States
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Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, 06437, United States
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Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, 06385, United States
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Smilow Cancer Hospital Care Center - Westerly
Westerly, Rhode Island, 02891, United States
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Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut, 06033, United States
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Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut, 06830, United States
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Smilow Cancer Hospital Care Center at Long Ridge
Stamford, Connecticut, 06902, United States
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Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, 06105, United States
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Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut, 06824, United States
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Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611, United States
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Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut, 06418, United States
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Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut, 06790, United States
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Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut, 06708, United States
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UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, 92868, United States
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UC San Diego Moores Cancer Center
La Jolla, California, 92093, United States
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UCHealth University of Colorado Hospital
Aurora, Colorado, 80045, United States
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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, 92612, United States
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UM Sylvester Comprehensive Cancer Center at Aventura
Aventura, Florida, 33180, United States
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UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, 33146, United States
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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, 33442, United States
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UM Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida, 33176, United States
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UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, 33324, United States
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UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136, United States
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University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, Wisconsin, 53718, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792, United States
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VCU Massey Comprehensive Cancer Center
Richmond, Virginia, 23298, United States
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Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Weisberg Cancer Treatment Center
Farmington Hills, Michigan, 48334, United States
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Yale University
New Haven, Connecticut, 06520, United States
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Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut, 06473, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Tumor DNA mapping may unlock personalized cancer therapies
- Can a new drug combo shrink Hard-to-Treat tumors?
- Can a targeted pill outperform chemo for bile duct cancer?
- Can a protein calm the immune System's overreaction to cancer treatment?
- Can a new drug shrink Hard-to-Treat tumors?