New cocktail for tough lung cancer shows promise in small trial

NCT ID NCT00334815

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 30, 2026 · Updated 5 times

Summary

This phase 2 pilot trial tested adding the drug bevacizumab to standard chemotherapy and radiation for patients with stage III non-small cell lung cancer that cannot be removed by surgery. The study enrolled 29 newly diagnosed patients to see if the combination is safe and helps control the cancer. Bevacizumab works by blocking blood flow to tumors, while chemo and radiation kill cancer cells directly.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bevacizumab (Avastin) plus cisplatin, etoposide, docetaxel, and radiation therapy
What this could lead to: If successful, this combination could improve control of advanced lung cancer that cannot be surgically removed, potentially extending survival.
What could go wrong: This is a small, early-phase pilot trial with only 29 participants, so results may not apply broadly. Adding bevacizumab to chemotherapy and radiation can increase side effects like bleeding or blood clots.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma of Lung adenosquamous lung carcinoma lung adenocarcinoma lung large cell carcinoma minimally invasive lung adenocarcinoma non-small cell lung carcinoma squamous cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG ADENOCARCINOMA LUNG ADENOSQUAMOUS CARCINOMA LUNG LARGE CELL CARCINOMA LUNG SQUAMOUS CELL CARCINOMA MINIMALLY INVASIVE LUNG ADENOCARCINOMA STAGE IIIA LUNG NON-SMALL CELL CANCER AJCC V7 STAGE IIIB LUNG NON-SMALL CELL CANCER AJCC V7

Contacts and locations

Locations

Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, 14905, United States
Audie L Murphy VA Hospital

San Antonio, Texas, 78229, United States
Ballad Health Cancer Care - Norton

Norton, Virginia, 24273, United States
Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Cancer Centers of Central Florida PA

Leesburg, Florida, 34788, United States
Dana-Farber Cancer Institute at Boston Medical Center - Brighton

Brighton, Massachusetts, 02135, United States
Danville Regional Medical Center

Danville, Virginia, 24541, United States
Denver Health Medical Center

Denver, Colorado, 80204, United States
Edward Hospital/Cancer Center

Naperville, Illinois, 60540, United States
Fremont - Rideout Cancer Center

Marysville, California, 95901, United States
Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California, 96161, United States
HaysMed

Hays, Kansas, 67601, United States
Highland Clinic

Shreveport, Louisiana, 71105, United States
Highland Hospital

Rochester, New York, 14620, United States
Highlands Oncology Group - Rogers

Rogers, Arkansas, 72758, United States
Hutchinson Regional Medical Center

Hutchinson, Kansas, 67502, United States
Kansas City Veterans Affairs Medical Center

Kansas City, Missouri, 64128, United States
LSU Health Sciences Center at Shreveport

Shreveport, Louisiana, 71103, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
McLaren Cancer Institute-Macomb

Mount Clemens, Michigan, 48043, United States
Montana Cancer Consortium NCORP

Billings, Montana, 59102, United States
Montrose Memorial Hospital

Montrose, Colorado, 81401, United States
MultiCare Allenmore Hospital

Tacoma, Washington, 98405, United States
MultiCare Auburn Medical Center

Auburn, Washington, 98001, United States
MultiCare Good Samaritan Hospital

Puyallup, Washington, 98372, United States
Northbay Cancer Center

Vacaville, California, 95687, United States
Novant Health Presbyterian Medical Center

Charlotte, North Carolina, 28204, United States
Olathe Cancer Center

Olathe, Kansas, 66061, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Portland VA Medical Center

Portland, Oregon, 97239, United States
Providence - Saint Peter Hospital

Olympia, Washington, 98506-5166, United States
Providence Hospital

Mobile, Alabama, 36608, United States
Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States
Providence Santa Rosa Memorial Hospital

Santa Rosa, California, 95405, United States
Rocky Mountain Regional VA Medical Center

Aurora, Colorado, 80045, United States
Roper Hospital

Charleston, South Carolina, 29401, United States
Saint Bernards Regional Medical Center

Jonesboro, Arkansas, 72401, United States
Saint Clare Hospital

Lakewood, Washington, 98499, United States
Saint Francis Hospital

Federal Way, Washington, 98003, United States
Saint Joseph Medical Center

Tacoma, Washington, 98405, United States
Salina Regional Health Center

Salina, Kansas, 67401, United States
Shaw Cancer Center

Edwards, Colorado, 81632, United States
Southeast Clinical Oncology Research Consortium NCORP

Winston-Salem, North Carolina, 27104, United States
The Don and Sybil Harrington Cancer Center

Amarillo, Texas, 79106, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
UT MD Anderson Cancer Center

Houston, Texas, 77030, United States
University Hospital

San Antonio, Texas, 78229, United States
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Rochester

Rochester, New York, 14642, United States
University of Tennessee Health Science Center

Memphis, Tennessee, 38163, United States
University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States
Valley View Hospital Cancer Center

Glenwood Springs, Colorado, 81601, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Wellmont Holston Valley Hospital and Medical Center

Kingsport, Tennessee, 37660, United States

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