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Could a vaccine stop colon cancer before it starts?

NCT ID NCT02134925

Ongoing ⭐️ VACCINE ⭐️ Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a vaccine that helps the body's immune system recognize and attack advanced colon polyps, which can turn into cancer. About 110 people who have had these polyps removed will receive either the vaccine or a placebo. The goal is to see if the vaccine boosts immune response and reduces the chance of polyps coming back.

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Conditions

The condition(s) this trial relates to.

adenomatous colon polyp colon dysplasia colorectal adenoma colorectal neoplasm colorectal tubulovillous adenoma colorectal cancer prevention target colorectal carcinoma prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL ADENOMA COLORECTAL ADENOMA WITH SEVERE DYSPLASIA COLORECTAL CARCINOMA COLORECTAL CONVENTIONAL ADENOMA WITH SEVERE DYSPLASIA COLORECTAL TUBULOVILLOUS ADENOMA

Contacts and locations

Locations

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Kansas City Veterans Affairs Medical Center

    Kansas City, Missouri, 64128, United States

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • University of Pittsburgh Cancer Institute (UPCI)

    Pittsburgh, Pennsylvania, 15232, United States

  • University of Puerto Rico

    San Juan, 00936, Puerto Rico

More trials for these conditions

Other studies related to the condition(s) this trial covers.