New drug combo tested for advanced cancers
NCT ID NCT01281176
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing two different doses of vorinostat (a drug that blocks enzymes needed for cancer cell growth) combined with either carboplatin or paclitaxel (standard chemotherapy drugs) in 20 people with advanced solid tumors that have not responded to other treatments. The main goal is to measure drug levels in the blood and check for side effects. This study aims to find safer and more effective ways to combine these drugs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vorinostat (a drug that may block enzymes needed for cancer cell growth) combined with carboplatin or paclitaxel (standard chemotherapy drugs)
What this could lead to
If successful, this could help determine safe and effective doses of vorinostat combined with chemotherapy for advanced solid tumors, potentially improving treatment options.
What could go wrong
This is a very early phase 1 trial with only 20 participants, so results may not apply to larger populations. Side effects from the drug combinations are unknown and could be severe.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ADVANCED SOLID TUMOR are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637, United States