Aspirin may help prevent return of precancerous esophagus condition
NCT ID NCT02521285
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether taking aspirin can prevent Barrett's esophagus from returning after it has been successfully removed with radiofrequency ablation. Researchers will measure levels of a protein linked to Barrett's in tissue samples from 21 participants over 12 months. The goal is to see if aspirin can keep the condition away safely.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Aspirin
What this could lead to
If it works, this could point toward a simple, low-cost way to prevent Barrett's esophagus from coming back after treatment.
What could go wrong
This is a very small, early-phase trial (21 people) looking at biomarkers, not whether cancer actually develops. Aspirin can cause bleeding, and results may not apply to everyone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030, United States
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Kansas City Veterans Affairs Medical Center
Kansas City, Missouri, 64128, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Saint Michael's Hospital
Toronto, Ontario, M5B 1W8, Canada
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UCHealth University of Colorado Hospital
Aurora, Colorado, 80045, United States
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UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, 90095, United States
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UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
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UT MD Anderson Cancer Center
Houston, Texas, 77030, United States
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University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania, 19104, United States