Aspirin may stop precancerous esophagus condition from returning

NCT ID NCT02521285

First seen Sep 30, 2025 · Last updated May 13, 2026 · Updated 19 times

Summary

This phase 2 trial tests whether taking aspirin can prevent Barrett's esophagus from returning after it has been successfully removed with radiofrequency ablation. About 21 participants will take either aspirin or a placebo for 12 months. Researchers will measure specific proteins in tissue samples to see if aspirin helps keep the condition away.

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Contacts and locations

Locations

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas, 77030, United States

  • Kansas City Veterans Affairs Medical Center

    Kansas City, Missouri, 64128, United States

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Saint Michael's Hospital

    Toronto, Ontario, M5B 1W8, Canada

  • UCHealth University of Colorado Hospital

    Aurora, Colorado, 80045, United States

  • UCLA / Jonsson Comprehensive Cancer Center

    Los Angeles, California, 90095, United States

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

  • University of Pennsylvania/Abramson Cancer Center

    Philadelphia, Pennsylvania, 19104, United States

Conditions

Explore the condition pages connected to this study.