New combo aims to outsmart Chemo-Resistant lung cancer

NCT ID NCT03896503

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This phase 2 trial tests whether adding berzosertib to standard chemotherapy (topotecan) helps people with relapsed small-cell lung cancer live longer without their cancer growing. About 104 participants will receive either the combo or topotecan alone. The goal is to see if berzosertib can block cancer cells from repairing DNA damage caused by chemo, making the treatment more effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: berzosertib (M6620, VX-970) combined with topotecan hydrochloride
What this could lead to: If successful, this combination could offer a new treatment option that delays cancer progression in patients with relapsed small-cell lung cancer.
What could go wrong: This is a mid-stage trial with only 104 participants, so results may not be definitive. Adding berzosertib may increase side effects without improving outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

small cell carcinoma small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTENSIVE STAGE LUNG SMALL CELL CARCINOMA EXTRAPULMONARY SMALL CELL NEUROENDOCRINE CARCINOMA LIMITED STAGE LUNG SMALL CELL CARCINOMA PLATINUM-RESISTANT LUNG SMALL CELL CARCINOMA PLATINUM-SENSITIVE LUNG SMALL CELL CARCINOMA RECURRENT LUNG SMALL CELL CARCINOMA

Contacts and locations

Locations

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States
HaysMed

Hays, Kansas, 67601, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Los Angeles General Medical Center

Los Angeles, California, 90033, United States
Mercy Hospital Pittsburg

Pittsburg, Kansas, 66762, United States
NCI - Center for Cancer Research

Bethesda, Maryland, 20892, United States
Parkland Memorial Hospital

Dallas, Texas, 75235, United States
Salina Regional Health Center

Salina, Kansas, 67401, United States
The University of Kansas Cancer Center - Olathe

Olathe, Kansas, 66061, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
USC Norris Oncology/Hematology-Newport Beach

Newport Beach, California, 92663, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
University Health Truman Medical Center

Kansas City, Missouri, 64108, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States
University of Kansas Clinical Research Center

Fairway, Kansas, 66205, United States
University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Indian Creek Campus

Overland Park, Kansas, 66211, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
Wake Forest Baptist Health - Hematology Oncology - Statesville

Statesville, North Carolina, 28677, United States
Wake Forest Baptist Health - Wilkes Medical Center

Wilkesboro, North Carolina, 28659, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Wake Forest University at Clemmons

Clemmons, North Carolina, 27012, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States

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