Targeted drug ibrutinib shows promise against rare leukemia

NCT ID NCT01841723

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests the drug ibrutinib in 44 people with hairy cell leukemia that has come back after treatment. Ibrutinib works by blocking a protein that helps cancer cells grow. The main goal is to see how many patients achieve remission within 32 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Ibrutinib (a targeted cancer drug)

What this could lead to

If it works, this could offer a new treatment option for people with hairy cell leukemia that has come back after previous therapy.

What could go wrong

This is a small, early-phase trial with only 44 people. The drug may not work for everyone, and side effects like bleeding or infection are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hairy cell leukemia hairy cell leukemia variant refractory hairy cell leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • UT MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Wayne State University/Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States