New hope for kids with tough cancers: elimusertib trial launches

NCT ID NCT05071209

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called elimusertib in children and young adults (ages 1 to 30) whose solid tumors have returned or not responded to treatment. The drug works by blocking an enzyme that cancer cells need to grow. The trial aims to find the safest dose and see if the drug can shrink tumors. It is a Phase 1/2 study with 31 participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Elimusertib (a drug that blocks an enzyme called ATR, which may help stop cancer cell growth)
What this could lead to: If it works, this could provide a new treatment option for children and young adults with hard-to-treat solid tumors that have come back or not responded to standard therapy.
What could go wrong: This is an early-phase trial (Phase 1/2) with only 31 participants, so the results may not apply to everyone. The drug may cause side effects or not shrink tumors as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alveolar rhabdomyosarcoma cancer Ewing sarcoma lymphoma refractory malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT ALVEOLAR RHABDOMYOSARCOMA RECURRENT EWING SARCOMA RECURRENT LYMPHOMA RECURRENT MALIGNANT SOLID NEOPLASM REFRACTORY ALVEOLAR RHABDOMYOSARCOMA REFRACTORY EWING SARCOMA REFRACTORY LYMPHOMA REFRACTORY MALIGNANT SOLID NEOPLASM

Contacts and locations

Locations

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States
C S Mott Children's Hospital

Ann Arbor, Michigan, 48109, United States
Centre Hospitalier Universitaire Sainte-Justine

Montreal, Quebec, H3T 1C5, Canada
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital of Alabama

Birmingham, Alabama, 35233, United States
Children's Hospital of Orange County

Orange, California, 92868, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, 15224, United States
Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Johns Hopkins All Children's Hospital

St. Petersburg, Florida, 33701, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Lurie Children's Hospital-Chicago

Chicago, Illinois, 60611, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Riley Hospital for Children

Indianapolis, Indiana, 46202, United States
Saint Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
UCSF Medical Center-Mission Bay

San Francisco, California, 94158, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, 55455, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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