New drug combo targets Hard-to-Treat thyroid cancer

NCT ID NCT01947023

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 22 times

Summary

This early-phase study tested a combination of two targeted drugs, dabrafenib and lapatinib, in 23 people with advanced thyroid cancer that has a specific BRAF gene mutation and has stopped responding to standard treatments. The main goal was to find the safest dose of lapatinib when given with dabrafenib, and to see how the drugs affect the tumor. This is not a cure, but aims to control the disease by blocking signals that help cancer cells grow.

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Contacts and locations

Locations

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

Conditions

Explore the condition pages connected to this study.