New hope for kids with tough cancer: drug combo shows promise

NCT ID NCT01711554

First seen Sep 30, 2025 · Last updated Apr 24, 2026 · Updated 22 times

Summary

This early-stage study tested a combination of drugs (lenalidomide, dinutuximab, and sometimes isotretinoin) in 27 children and young adults with neuroblastoma that didn't respond to treatment or came back. The main goal was to find the safest dose and check side effects. Researchers also looked at how the treatment affected the immune system and overall survival.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

  • C S Mott Children's Hospital

    Ann Arbor, Michigan, 48109, United States

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital

    Atlanta, Georgia, 30329, United States

  • Children's Hospital Colorado

    Aurora, Colorado, 80045, United States

  • Children's Hospital Los Angeles

    Los Angeles, California, 90027, United States

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

  • Cook Children's Medical Center

    Fort Worth, Texas, 76104, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Hospital for Sick Children

    Toronto, Ontario, M5G 1X8, Canada

  • Lucile Packard Children's Hospital Stanford University

    Palo Alto, California, 94304, United States

  • Seattle Children's Hospital

    Seattle, Washington, 98105, United States

  • UCSF Medical Center-Parnassus

    San Francisco, California, 94143, United States

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

  • University of Chicago Comer Children's Hospital

    Chicago, Illinois, 60637, United States

Conditions

Explore the condition pages connected to this study.