New hope for kids with neuroblastoma: experimental combo enters human testing

NCT ID NCT01711554

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a combination of three drugs—lenalidomide, dinutuximab, and isotretinoin—in children whose neuroblastoma has not responded to treatment or has come back. The main goal is to find the safest dose of lenalidomide when used with the other drugs. Researchers will also look at how the treatment affects the immune system. The study involves 27 participants and is no longer recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lenalidomide, dinutuximab, and isotretinoin
What this could lead to: If this works, it could point toward a new combination treatment for children with neuroblastoma that has not responded to standard therapy or has returned.
What could go wrong: This is a very early phase I trial with only 27 participants, focused on safety and dosing. It is not designed to prove effectiveness, and side effects may be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neuroblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT NEUROBLASTOMA REFRACTORY NEUROBLASTOMA

Contacts and locations

Locations

Boston Children's Hospital

Boston, Massachusetts, 02115, United States
C S Mott Children's Hospital

Ann Arbor, Michigan, 48109, United States
Children's Healthcare of Atlanta - Arthur M Blank Hospital

Atlanta, Georgia, 30329, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada
Lucile Packard Children's Hospital Stanford University

Palo Alto, California, 94304, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
UCSF Medical Center-Parnassus

San Francisco, California, 94143, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
University of Chicago Comer Children's Hospital

Chicago, Illinois, 60637, United States

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