Experimental combo aims to outsmart relapsed blood cancers
NCT ID NCT02890329
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests whether adding the immunotherapy drug ipilimumab to the chemotherapy drug decitabine is safe and tolerable for people with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) that has come back or stopped responding to treatment. About 54 participants will receive the combination to find the best dose and watch for any anti-cancer effects. The goal is to see if this approach can help control these difficult-to-treat blood cancers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ipilimumab (an immunotherapy drug) and decitabine (a chemotherapy drug)
What this could lead to
If it works, this could point toward a new treatment option for people with hard-to-treat MDS or AML that has returned or not responded to prior therapy.
What could go wrong
This is a very early Phase 1 trial with only 54 participants, focused on safety and dosing. It is not designed to prove effectiveness, and the combination may cause significant side effects or fail to control the disease.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Case Western Reserve University
Cleveland, Ohio, 44106, United States
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Northside Hospital
Atlanta, Georgia, 30342, United States
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UC San Diego Moores Cancer Center
La Jolla, California, 92093, United States
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University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
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University of Virginia Cancer Center
Charlottesville, Virginia, 22908, United States