New combo therapy gives hope to melanoma patients who failed standard treatment
NCT ID NCT02965716
First seen Nov 18, 2025 · Last updated May 14, 2026 · Updated 24 times
Summary
This study tests whether combining two immunotherapy drugs—T-VEC (a virus-based therapy injected into tumors) and pembrolizumab (an antibody given by IV)—can shrink tumors in people with advanced melanoma that no longer responds to standard immunotherapy. About 43 adults with stage III or IV melanoma that cannot be surgically removed are participating. The goal is to see if this combination can control the disease and provide lasting responses.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Allegiance Health
Jackson, Michigan, 49201, United States
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CTCA at Western Regional Medical Center
Goodyear, Arizona, 85338, United States
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Henry Ford Cancer Institute-Downriver
Brownstown, Michigan, 48183, United States
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan, 48038, United States
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Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, 48322, United States
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Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112, United States
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Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202, United States
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Kansas City Veterans Affairs Medical Center
Kansas City, Missouri, 64128, United States
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Keck Medical Center of USC Pasadena
Pasadena, California, 91105, United States
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Los Angeles General Medical Center
Los Angeles, California, 90033, United States
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Loyola University Medical Center
Maywood, Illinois, 60153, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, 90095, United States
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USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio, 45219, United States
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University of Cincinnati Cancer Center-West Chester
West Chester, Ohio, 45069, United States
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University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, 66205, United States
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University of South Alabama Mitchell Cancer Institute
Mobile, Alabama, 36688, United States
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Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232, United States
Conditions
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